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Genetic Constructor: An Online DNA Design Platform
ACS Synthetic Biology ( IF 4.7 ) Pub Date : 2017-10-20 00:00:00 , DOI: 10.1021/acssynbio.7b00236
Maxwell Bates 1 , Joe Lachoff 1 , Duncan Meech 1 , Valentin Zulkower 2 , Anaïs Moisy 2 , Yisha Luo 2 , Hille Tekotte 2 , Cornelia Johanna Franziska Scheitz 1 , Rupal Khilari 1 , Florencio Mazzoldi 1 , Deepak Chandran 3 , Eli Groban 1
Affiliation  

Genetic Constructor is a cloud Computer Aided Design (CAD) application developed to support synthetic biologists from design intent through DNA fabrication and experiment iteration. The platform allows users to design, manage, and navigate complex DNA constructs and libraries, using a new visual language that focuses on functional parts abstracted from sequence. Features like combinatorial libraries and automated primer design allow the user to separate design from construction by focusing on functional intent, and design constraints aid iterative refinement of designs. A plugin architecture enables contributions from scientists and coders to leverage existing powerful software and connect to DNA foundries. The software is easily accessible and platform agnostic, free for academics, and available in an open-source community edition. Genetic Constructor seeks to democratize DNA design, manufacture, and access to tools and services from the synthetic biology community.

中文翻译:

遗传构建器:在线DNA设计平台

遗传构造器是一种云计算机辅助设计(CAD)应用程序,旨在支持合成生物学家从设计意图到DNA制备和实验迭代。该平台允许用户使用一种新的可视化语言来设计,管理和导航复杂的DNA构建体和文库,该可视化语言侧重于从序列中提取的功能部分。组合库和自动引物设计等功能使用户可以通过专注于功能意图将设计与构造分离,而设计约束则有助于迭代式设计的改进。插件架构使科学家和编码人员的贡献可以利用现有功能强大的软件并连接到DNA代工厂。该软件易于访问且与平台无关,对学者免费,并以开源社区版本提供。
更新日期:2017-10-20
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