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Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.
Cell Chemical Biology ( IF 8.6 ) Pub Date : 2017-10-19 , DOI: 10.1016/j.chembiol.2017.09.012
Zhijun Guo , Irina F. Sevrioukova , Ilia G. Denisov , Xia Zhang , Ting-Lan Chiu , Dafydd G. Thomas , Eric A. Hanse , Rebecca A.D. Cuellar , Yelena V. Grinkova , Vanessa Wankhede Langenfeld , Daniel S. Swedien , Justin D. Stamschror , Juan Alvarez , Fernando Luna , Adela Galván , Young Kyung Bae , Julia D. Wulfkuhle , Rosa I. Gallagher , Emanuel F. Petricoin , Beverly Norris , Craig M. Flory , Robert J. Schumacher , M. Gerard O’Sullivan , Qing Cao , Haitao Chu , John D. Lipscomb , William M. Atkins , Kalpna Gupta , Ameeta Kelekar , Ian A. Blair , Jorge H. Capdevila , John R. Falck , Stephen G. Sligar , Thomas L. Poulos , Gunda I. Georg , Elizabeth Ambrose , David A. Potter

(Cell Chemical Biology24, 1259–1275; October 19, 2017) During the cropping of Figure 2H, the image of the p62 row was deleted in error and then remaining labels were shifted down by one row and were therefore out of registration with the images. Figure 2H has now been corrected in the article online and in print; the corrected Figure 2H is also shown below. The authors apologize for this labeling error.FigureFigure 2H. CYP3A4 Suppresses AMPK through Its EET Products, while Metformin Binds to the CYP3A4 Active-Site Heme and Inhibits EET Biosynthesis (original)View Large ImageFigure ViewerDownload Hi-res imageDownload (PPT)

中文翻译:

血红素结合双胍靶向细胞色素P450依赖的癌细胞线粒体。

(Cell Chemical Biology24,1259–1275; 2017年10月19日)在裁剪图2H期间,p62行的图像被错误删除,然后剩余的标签向下移动了一行,因此与该图像不对齐。现在在线和印刷文章中已对图2H进行了更正;校正后的图2H也显示在下面。作者对此标记错误深表歉意。图2H。CYP3A4通过其EET产品抑制AMPK,而二甲双胍与CYP3A4活性部位血红素结合并抑制EET生物合成(原始)
更新日期:2017-10-19
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