A simple, economical and one‐pot protocol is developed for construction of multiple carbon–carbon bonds having C(sp²)−C(sp²) and C(sp²)−C(sp) hybridization, as these intriguing molecular architectures exhibit significant optoelectronic and medicinal properties. To this end, a sequential reaction is devised that allows one‐pot three‐component reactions of hydroxybenzaldehydes (C₆–C₁ unit), halo‐phenylacetic acids (C₆–C₂ unit) and arylacetylenes (C₆–C₃ unit) resulting in the formation of highly π‐conjugated complex arylethenyl‐arylethynyl‐arenes (C₆–C₂–C₆–C₂–C₆ unit) bearing a hydroxy group via sequential Perkin condensation–decarboxylation–Sonogashira coupling in polyethylene glycol with microwave irradiation. The process avoids protection–deprotection manipulations, generates CO₂ and H₂O as by‐products and is successfully extended for the efficient construction of a wide series of novel aliphatic/alicyclic/(hetero)aromatic arylethenyl‐arylethynyl‐arenes with pendant hydroxy functionality, which could undergo further chemical modification to achieve target biological and physical properties.

中文翻译：

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通过顺序脱羧Perkin-Sonogashira反应的羟化芳基乙烯基-芳基乙炔基芳烃的锅经济合成

开发了一种简单，经济且一锅的方案，用于构建具有C（sp ²）-C（sp ²）和C（sp ²）-C（sp）杂化的多个碳-碳键，因为这些有趣的分子结构表现出显着的光电和药用特性。为此，连续的反应被设计，其允许羟基苯甲醛的一锅三组分反应（C ₆ -C ₁单元），卤代苯乙酸（C ₆ -C ₂单元）和arylacetylenes（C ₆ -C ₃单元）导致形成高度π共轭的复杂芳基乙烯基-芳基乙炔基芳烃（C ₆ –C ₂ –C₆ –C ₂ –C ₆单元）通过在微波辐射下在聚乙二醇中进行的Perkin缩合-脱羧-Sonogashira偶联而带有羟基。该过程避免了保护-脱保护操作，产生了副产品CO ₂和H ₂ O，并成功地扩展了用于新型含侧链羟基官能团的脂族/脂环族/（杂）芳族芳基乙烯基-芳基乙炔基芳烃的有效构造的范围。 ，可以对其进行进一步的化学修饰以实现目标生物学和物理性质。