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The transferrin receptor: the cellular iron gate
Metallomics ( IF 3.4 ) Pub Date : 2017-06-13 00:00:00 , DOI: 10.1039/c7mt00143f
Elena Gammella 1, 2, 3, 4 , Paolo Buratti 1, 2, 3, 4 , Gaetano Cairo 1, 2, 3, 4 , Stefania Recalcati 1, 2, 3, 4
Affiliation  

The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis. Since the number of TfR1 molecules at the cell surface is the rate-limiting step for iron entry into cells and is essential to prevent iron overload, TfR1 expression is precisely controlled at multiple levels. In this review, we have discussed the latest advances in the molecular regulation of TfR1 expression and we have considered current understanding of TfR1 function beyond its canonical role in providing iron for erythroid precursors and rapidly proliferating cells.

中文翻译:

转铁蛋白受体:细胞铁门

转铁蛋白受体(TfR1)通过铁载铁蛋白的网格蛋白依赖性内吞作用介导细胞摄取铁,在铁稳态中起关键作用。由于细胞表面TfR1分子的数量是铁进入细胞的限速步骤,并且对于防止铁超载是必不可少的,因此TfR1的表达被精确地控制在多个水平。在这篇综述中,我们讨论了TfR1表达的分子调控的最新进展,并且考虑了当前对TfR1功能的理解,而不仅仅是它在为红系前体和快速增殖的细胞提供铁方面的典型作用。
更新日期:2017-06-13
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