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Transfer of Antibiotic Resistance in Staphylococcus aureus
Trends in Microbiology ( IF 15.9 ) Pub Date : 2017-06-20 , DOI: 10.1016/j.tim.2017.05.011
Jakob Haaber , José R. Penadés , Hanne Ingmer

Staphylococcus aureus is a serious human pathogen with remarkable adaptive powers. Antibiotic-resistant clones rapidly emerge mainly by acquisition of antibiotic-resistance genes from other S. aureus strains or even from other genera. Transfer is mediated by a diverse complement of mobile genetic elements and occurs primarily by conjugation or bacteriophage transduction, with the latter traditionally being perceived as the primary route. Recent work on conjugation and transduction suggests that transfer by these mechanisms may be more extensive than previously thought, in terms of the range of plasmids that can be transferred by conjugation and the efficiency with which transduction occurs. Here, we review the main routes of antibiotic resistance gene transfer in S. aureus in the context of its biology as a human commensal and a life-threatening pathogen.



中文翻译:

金黄色葡萄球菌中抗生素耐药性的转移

金黄色葡萄球菌是一种严重的人类病原体,具有出色的适应能力。耐药菌克隆主要通过从其他金黄色葡萄球菌菌株甚至其他属获得抗生素耐药基因而迅速出现。转移是由多种多样的移动遗传元件介导的,主要通过结合或噬菌体转导发生,传统上将后者视为主要途径。关于缀合和转导的最新研究表明,就可以通过缀合转移的质粒范围和发生转导的效率而言,通过这些机制进行的转移可能比以前认为的要广泛。在这里,我们回顾了金黄色葡萄球菌中抗生素抗性基因转移的主要途径 在其生物学上作为人类常识和威胁生命的病原体而存在。

更新日期:2017-06-20
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