The cover picture shows a chemical approach to generating tumor‐specific cytotoxic T cells by using Ac4ManNAz as a small‐molecule engager. T cells were first cultured in Ac4ManNAz and then incubated with Alexa Fluor 488 dibenzocyclooctynol (DIBO) to achieve the tumor‐specific targeting. These tumor‐specific cytotoxic T cells amplified and secreted cytokines after interaction with tumor cells. This method poses no risk of insertional mutagenesis, thereby making it feasible as a safe approach for the production of tumor‐specific cytotoxic T cells in cancer immunotherapy. More importantly, the displayed azido moiety and the tethered ligands remain stable only for a few days, thus allowing the control of cytotoxicity and cytokine release. This chemical approach provides a facile platform for the rational design of tumor‐specific cytotoxic T cells for targeted immunotherapy. More information can be found in the communication by Q. Xia, D. Zhou et al. on page 2082 in Issue 21, 2017 (DOI: 10.1002/cbic.201700340).

中文翻译：

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封面：通过掺入叠氮糖的配体配体来重定向杀伤性T细胞（ChemBioChem 21/2017）

封面图片显示一种通过使用Ac4ManNAz作为小分子衔接子来生成肿瘤特异性细胞毒性T细胞的化学方法。首先在Ac4ManNAz中培养T细胞，然后与Alexa Fluor 488二苯并环辛炔醇（DIBO）孵育以实现肿瘤特异性靶向。这些肿瘤特异性细胞毒性T细胞在与肿瘤细胞相互作用后会扩增并分泌细胞因子。该方法不存在插入诱变的风险，因此使其成为在癌症免疫疗法中生产肿瘤特异性细胞毒性T细胞的安全方法是可行的。更重要的是，展示的叠氮基部分和束缚的配体仅在几天内保持稳定，因此可以控制细胞毒性和细胞因子的释放。这种化学方法为合理设计靶向免疫疗法的肿瘤特异性细胞毒性T细胞提供了一个简便的平台。可以在Q. Xia，D. Zhou等人的来文中找到更多信息。上2017年第21期，第2082页（DOI：10.1002 / cbic.201700340）。