We developed a biodegradable polycarbonate that demonstrates antithrombogenicity and vascular cell adhesion via organocatalytic ring-opening polymerization of a trimethylene carbonate (TMC) analogue bearing a methoxy group. The monoether-tagged polycarbonate demonstrates a platelet adhesion property that is 93 and 89% lower than those of poly(ethylene terephthalate) and polyTMC, respectively. In contrast, vascular cell adhesion properties of the polycarbonate are comparable to those controls, indicating a potential for selective cell adhesion properties. This difference in the cell adhesion property is well associated with surface hydration, which affects protein adsorption and denaturation. Fibrinogen is slightly denatured on the monoether-tagged polycarbonate, whereas fibronectin is highly activated to expose the RGD motif for favorable vascular cell adhesion. The surface hydration, mainly induced by the methoxy side chain, also contributes to slowing the enzymatic degradation. Consequently, the polycarbonate exhibits decent blood compatibility, vascular cell adhesion properties, and biodegradability, which is promising for applications in resorbable vascular grafts and stents.

中文翻译：

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单醚标记的可生物降解聚碳酸酯，可防止血小板粘附并显示血管细胞粘附：可吸收的血管移植物和支架的有前途的材料

我们开发了一种可生物降解的聚碳酸酯，该聚合物通过带有甲氧基的碳酸三亚甲基酯（TMC）类似物的有机催化开环聚合反应，显示出抗血栓形成性和血管细胞粘附性。单醚标记的聚碳酸酯具有比聚对苯二甲酸乙二醇酯和聚TMC分别低93％和89％的血小板粘附性能。相反，聚碳酸酯的血管细胞粘附特性与那些对照相当，表明潜在的选择性细胞粘附特性。细胞粘附特性的这种差异与表面水合作用密切相关，这会影响蛋白质的吸附和变性。纤维蛋白原在单醚标记的聚碳酸酯上略微变性，而纤连蛋白则被高度激活以暴露RGD基序，从而有利于维管细胞的粘附。主要由甲氧基侧链诱导的表面水合作用也有助于减缓酶促降解。因此，聚碳酸酯显示出良好的血液相容性，血管细胞粘附特性和生物降解性，这有望用于可吸收性血管移植物和支架中。