As a noninvasive treatment method, photothermal therapy (PTT) has been widely investigated for cancer therapy. In this work, metal–organic frameworks@polymer composites (UiO-66@CyP) with bioimaging and PTT activity were prepared by introducing cyanine-containing polymer (CyP) via multicomponent Passerini reaction in the presence of Zr-based nanoscale metal–organic frameworks (UiO-66). As-prepared UiO-66@CyP not only possesses uniformed size, controllable morphology, and excellent dispersibility in aqueous media, but also indicates strong near-infrared absorption and high photothermal conversion efficiency. Due to these combined merits, UiO-66@CyP appears to be an excellent phototherapy agent for ablation of tumor cells under a low-power laser irradiation and near-infrared fluorescence imaging agent. This work might open up a new avenue to develop multifunctional composites by integrating metal–organic frameworks with carboxyl, aldehyde, and isocyano-containing materials.

中文翻译：

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金属-有机骨架@包含花菁的聚合物复合材料，用于近红外荧光成像和光热肿瘤治疗

作为无创治疗方法，光热疗法（PTT）已被广泛用于癌症治疗。在这项工作中，通过在Zr基纳米级金属-有机骨架的存在下，通过多组分Passerini反应引入含花青的聚合物（CyP），制备具有生物成像和PTT活性的金属-有机骨架@聚合物复合材料（UiO-66 @ CyP）。 （UiO-66）。制备的UiO-66 @ CyP不仅具有均一的尺寸，可控的形态和在水性介质中的优异分散性，而且还显示出强的近红外吸收和高的光热转化效率。由于这些优点，UiO-66 @ CyP似乎是在低功率激光照射和近红外荧光成像剂的作用下消融肿瘤细胞的优秀光疗剂。