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Emerging and evolving concepts in gene essentiality
Nature Reviews Genetics ( IF 42.7 ) Pub Date : , DOI: 10.1038/nrg.2017.74 Giulia Rancati,Jason Moffat,Athanasios Typas,Norman Pavelka
Nature Reviews Genetics ( IF 42.7 ) Pub Date : , DOI: 10.1038/nrg.2017.74 Giulia Rancati,Jason Moffat,Athanasios Typas,Norman Pavelka
Emerging and evolving concepts in gene essentiality
中文翻译:
基因重要性方面的新兴概念
基因重要性方面的新兴概念
更新日期:2017-10-16
Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.74
Identifying which genes in a genome are essential for survival has been a long-standing goal of geneticists. This Review discusses our evolving understanding of cellular gene essentiality across diverse organisms. It describes how essentiality is often non-absolute but is instead dependent on the environment or genetic background and how this knowledge can be exploited therapeutically.
中文翻译:
基因重要性方面的新兴概念
基因重要性方面的新兴概念
《自然评论遗传学》(Nature Reviews Genetics),在线发布:2017年10月16日; doi:10.1038 / nrg.2017.74
鉴定基因组中哪些基因对于生存至关重要,这一直是遗传学家的长期目标。这篇评论讨论了我们对跨各种生物的细胞基因重要性的不断发展的理解。它描述了必需性如何经常不是绝对的,而是取决于环境或遗传背景,以及如何通过治疗来利用这些知识。