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The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
Nature Reviews Genetics ( IF 42.7 ) Pub Date :  , DOI: 10.1038/nrg.2017.80
Frank Lyko

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

Nature Reviews Genetics, Published online: 16 October 2017; doi:10.1038/nrg.2017.80

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes. Recent studies have increased our understanding of how DNMT activity is regulated and revealed that, in addition to establishing and maintaining DNA methylation patterns, DNMT enzymes function in transcriptional silencing, transcriptional activation and post-transcriptional regulation.



中文翻译:

DNA甲基转移酶家族:用于表观遗传调控的多功能工具包

DNA甲基转移酶家族:用于表观遗传调控的多功能工具包

《自然评论遗传学》(Nature Reviews Genetics),在线发布:2017年10月16日; doi:10.1038 / nrg.2017.80

DNA甲基转移酶(DNMT)家族包含一组保守的DNA修饰酶。最近的研究增加了我们对DNMT活性调控方式的了解,并揭示了DNMT酶除了建立和维持DNA甲基化模式外,还可以在转录沉默,转录激活和转录后调控中发挥作用。

更新日期:2017-10-16
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