Recent work demonstrating the role of chromosome organization in transcriptional regulation has sparked substantial interest in the molecular mechanisms that control chromosome structure. Condensin, an evolutionarily conserved multisubunit protein complex, is essential for chromosome condensation during cell division and functions in regulating gene expression during interphase. In Caenorhabditis elegans, a specialized condensin forms the core of the dosage compensation complex (DCC), which specifically binds to and represses transcription from the hermaphrodite X chromosomes. DCC serves as a clear paradigm for addressing how condensins target large chromosomal domains and how they function to regulate chromosome structure and transcription. Here, we discuss recent research on C. elegans DCC in the context of canonical condensin mechanisms as have been studied in various organisms.

证明染色体组织在转录调控中的作用的最新工作引起了人们对控制染色体结构的分子机制的极大兴趣。凝集素是一种进化上保守的多亚基蛋白复合物，对于细胞分裂过程中的染色体凝集至关重要，并在相间过程中起着调控基因表达的作用。在秀丽隐杆线虫中，专门的凝缩素形成剂量补偿复合物（DCC）的核心，该复合物特异性结合并抑制雌雄同体X染色体的转录。DCC是解决浓缩蛋白如何靶向大染色体结构域以及它们如何调节染色体结构和转录的清晰范式。在这里，我们讨论线虫的最新研究 在经典缩合蛋白机制的背景下，DCC已在各种生物中进行了研究。