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Facile Preparation of Doxorubicin-Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N-vinyl pyrrole) for Targeted Synergistic Chemo–Photothermal Cancer Treatment
Bioconjugate Chemistry ( IF 4.7 ) Pub Date : 2017-10-13 00:00:00 , DOI: 10.1021/acs.bioconjchem.7b00515
Daquan Wang 1 , Yibo Ren 2 , Yongping Shao 2 , Demei Yu 1 , Lingjie Meng 1, 3
Affiliation  

We developed a bifunctional nanoplatform for targeted synergistic chemo–photothermal cancer treatment. The nanoplatform was constructed through a facile method in which poly(N-vinyl pyrrole) (PVPy) was coated on cut multiwalled carbon nanotubes (c-MWNTs); FA-PEG-SH was then linked by thiol–ene click reaction to improve the active targeting ability, water dispersibility, and biocompatibility and to extend the circulation time in blood. The PVPy shell not only enhanced the photothermal effect of c-MWNTs significantly but also provided a surface that could tailor targeting molecules and drugs. The resulting MWNT@PVPy-S-PEG-FA possessed high drug-loading ratio as well as pH-sensitive unloading capacity for a broad-spectrum anticancer agent, doxorubicin. Owing to its outstanding efficiency in photothermal conversion and ability in targeted drug delivery, the material could potentially be used as an efficient chemo–photothermal therapeutic nanoagent to treat cancer.

中文翻译:

阿霉素负载和叶酸结合的碳纳米管@聚(N-乙烯基吡咯)的简便制备用于靶向协同化学光热癌治疗

我们开发了一种用于靶向协同化学光热癌症治疗的双功能纳米平台。纳米平台是通过一种简便的方法构建的,其中聚(N(乙烯基吡咯)(PVPy)涂覆在切割的多壁碳纳米管(c-MWNTs)上;然后通过硫醇-烯点击反应将FA-PEG-SH连接起来,以改善主动靶向能力,水分散性和生物相容性,并延长血液循环时间。PVPy壳不仅显着增强了c-MWNTs的光热效应,而且还提供了可以定制靶向分子和药物的表面。所得的MWNT @ PVPy-S-PEG-FA具有高载药率以及对广谱抗癌药阿霉素具有pH敏感性的载药能力。由于其出色的光热转换效率和靶向药物输送能力,该材料有可能被用作治疗癌症的有效化学光热治疗纳米剂。
更新日期:2017-10-13
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