Abstract Electrospun polymeric meshes are known to exhibit promising properties for the regeneration of several soft tissues. Herein, electrospun polymeric meshes were prepared from blends of polycaprolactone and functionalized gelatin. The meshes were then photocrosslinked under UV light using Irgacure® 2959 as the photoinitiator, aiming to improve membranes’ stability in biological fluids. Moreover, meshes suitability to be used as vascular grafts was evaluated by characterizing their chemical/physical properties as well as their haemo and biocompatibility in vitro. The obtained results show that the blended polymeric meshes are biodegradable and those with a higher content of gelatin display a lower water contact angle. Blood compatibility studies showed that the photocrosslinked membranes are haemocompatible, i.e. they display low values of thrombogenicity and do not trigger any haemolytic effect. Also, Normal Human Dermal Fibroblasts cells were incubated in the presence of the produced membranes and they were able to adhere and proliferate, thus revealing the biocompatibility of the photocrosslinked meshes.

中文翻译：

---

用于组织工程应用的可光交联电纺纤维网

摘要 众所周知，静电纺丝聚合物网在几种软组织再生方面表现出有前途的特性。在此，电纺聚合物网是由聚己内酯和功能化明胶的共混物制备的。然后使用 Irgacure® 2959 作为光引发剂在紫外线下对网状物进行光交联，旨在提高膜在生物体液中的稳定性。此外，通过表征它们的化学/物理特性以及它们的体外血液和生物相容性来评估网片作为血管移植物的适用性。所得结果表明，共混聚合物网是可生物降解的，而明胶含量较高的网则显示出较低的水接触角。血液相容性研究表明，光交联膜具有血液相容性，即 它们显示出低的血栓形成值并且不会引发任何溶血作用。此外，正常人真皮成纤维细胞在产生的膜存在下孵育，它们能够粘附和增殖，从而揭示光交联网的生物相容性。