Building devices from parts: We demonstrate a new modular approach to post-translationally assemble antibody-like “devices” from well-behaved antibody domains or “parts” using the SpyTag/SpyCatcher protein-ligase system. This system allows antibody parts to be assembled in configurations that are not possible with genetic engineering approaches.

中文翻译：

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通过使用SpyTag / SpyCatcher蛋白-连接酶系统构建合成模块化抗体

从零件构建设备：我们展示了一种新的模块化方法，可使用SpyTag / SpyCatcher蛋白连接酶系统从行为良好的抗体域或“部分”中翻译后组装抗体样“设备”。该系统允许抗体零件以基因工程方法无法实现的构型进行组装。