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Biosensing: Graphene Field‐Effect Transistors for the Sensitive and Selective Detection of Escherichia coli Using Pyrene‐Tagged DNA Aptamer (Adv. Healthcare Mater. 19/2017)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-10-11 , DOI: 10.1002/adhm.201770099
Guangfu Wu 1 , Ziwen Dai 2 , Xin Tang 1 , Zihong Lin 1 , Pik Kwan Lo 2 , M. Meyyappan 3 , King Wai Chiu Lai 1
Affiliation  

An aptamer modified graphene field‐effect transistor (G‐FET) based biosensor for electrical detection of E. coli is developed by King Wai Chiu Lai and co‐workers in article number 1700736. The change of the carrier density in graphene due to the attachment of E. coli is correlated with the electrical response of the graphene biosensors. The electrical response is analyzed and optimized by tuning the gate voltage which affects the carrier mobility of graphene. The excellent sensing performance (high sensitivity, selectivity and stability) opens up the possibility to utilize aptamer modified graphene device for pathogens detection in food and water quality monitoring and early diagnosis of pathogen infections.
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中文翻译:

生物传感:石墨烯场效应晶体管,用于使用标记的DNA适体敏感和选择性地检测大肠杆菌(Adv。Healthcare Mater。19/2017)

King Wai Chiu Lai及其同事在产品编号1700736中开发了一种基于适配子修饰的石墨烯场效应晶体管(G-FET)的生物传感器,用于大肠杆菌的电检测。石墨烯中的载流子密度由于附着而发生了变化。的大肠杆菌与石墨烯的生物传感器的电响应相关。通过调整影响石墨烯载流子迁移率的栅极电压来分析和优化电响应。出色的感测性能(高灵敏度,选择性和稳定性)为在食品和水质监测以及病原体感染的早期诊断中使用适体修饰的石墨烯设备进行病原体检测提供了可能性。
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更新日期:2017-10-11
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