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Social impairments in autism spectrum disorder are related to maternal immune history profile.
Molecular Psychiatry ( IF 11.0 ) Pub Date : 2018-Aug-01 , DOI: 10.1038/mp.2017.201
S Patel , A Masi , R C Dale , A J O Whitehouse , I Pokorski , G A Alvares , I B Hickie , E Breen , A J Guastella

Maternal immune activation has been highlighted as a factor that might increase the risk and severity of autism spectrum disorder (ASD) in children. Preclinical animal evidence shows that immune activation in mothers during pregnancy causes ASD-like behavioural traits in offspring. To this point, there has been no investigation of whether immune system activation in human mothers during pregnancy is associated with more severe symptoms in children with ASD. In this study, data from an existing ASD cohort (N=220) were analysed to investigate whether immune conditions in the mother were associated with greater severity of autism-related symptoms. Results showed that children whose mothers reported a history of immune activation (allergies and asthma) had significantly higher scores on the Social Responsiveness Scale (SRS; P=0.016), suggesting more severe social impairment symptoms in these children. This increasing severity of social impairment symptoms was further shown on the SRS cognition (P=0.007) and mannerisms (P=0.002) subscales. While immune history was associated with an increase in the severity of social impairment symptoms, history of autoimmune conditions in the mother did not have any effect in this cohort. To the best of our knowledge, this study is the first to show an association between immune activation history in the mother and increased ASD symptom severity in children with ASD. These findings support the idea of an immune system-mediated subtype in ASD, where the immune history of the mother may be an important factor.

中文翻译:

自闭症谱系障碍的社会障碍与母体免疫史有关。

孕产妇的免疫激活已被强调为可能增加儿童自闭症谱系障碍(ASD)的风险和严重性的因素。临床前动物证据表明,怀孕期间母亲的免疫激活会导致后代的ASD行为特征。到目前为止,还没有关于妊娠期人类母亲的免疫系统激活是否与更严重的自闭症儿童症状相关的调查。在这项研究中,分析了来自现有ASD队列(N = 220)的数据,以调查母亲的免疫状况是否与自闭症相关症状的严重程度相关。结果显示,其母亲报告有免疫激活史(过敏和哮喘)的儿童在社会反应能力量表(SRS; P = 0.016)上的得分明显较高,提示这些儿童的社交障碍症状更为严重。在SRS认知(P = 0.007)和举止(P = 0.002)子量表上进一步显示出这种社交障碍症状的严重程度增加。虽然免疫史与社交障碍症状严重程度的增加有关,但母亲的自身免疫病史对这一队列没有任何影响。据我们所知,这项研究是首次显示母亲的免疫激活史与ASD儿童的ASD症状严重程度增加之间的相关性。这些发现支持了ASD中免疫系统介导的亚型的想法,其中母亲的免疫史可能是重要因素。在SRS认知(P = 0.007)和举止(P = 0.002)子量表上进一步显示出这种社交障碍症状的严重程度增加。虽然免疫史与社交障碍症状严重程度的增加有关,但母亲的自身免疫病史对这一队列没有任何影响。据我们所知,这项研究是首次显示母亲的免疫激活史与ASD儿童的ASD症状严重程度增加之间的相关性。这些发现支持了ASD中免疫系统介导的亚型的想法,其中母亲的免疫史可能是重要因素。在SRS认知(P = 0.007)和举止(P = 0.002)子量表上进一步显示出这种社交障碍症状的严重程度增加。虽然免疫史与社交障碍症状严重程度的增加有关,但母亲的自身免疫病史对这一队列没有任何影响。据我们所知,这项研究是首次显示母亲的免疫激活史与ASD儿童的ASD症状严重程度增加之间的相关性。这些发现支持了ASD中免疫系统介导的亚型的想法,其中母亲的免疫史可能是重要因素。母亲自身免疫性疾病的病史对这一队列没有任何影响。据我们所知,这项研究是首次显示母亲的免疫激活史与ASD儿童的ASD症状严重程度增加之间的相关性。这些发现支持了ASD中免疫系统介导的亚型的想法,其中母亲的免疫史可能是重要因素。母亲自身免疫性疾病的病史对这一队列没有任何影响。据我们所知,这项研究是首次显示母亲的免疫激活史与ASD儿童的ASD症状严重程度增加之间的相关性。这些发现支持了ASD中免疫系统介导的亚型的想法,其中母亲的免疫史可能是重要因素。
更新日期:2017-10-11
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