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Immunotherapy: CD8+ T cells — burn fat, get fit
Nature Reviews Cancer ( IF 78.5 ) Pub Date : 2017-10-06 , DOI: 10.1038/nrc.2017.94
Conor A. Bradley

Immunotherapy: CD8+ T cells — burn fat, get fit

Nature Reviews Cancer, Published online: 6 October 2017; doi:10.1038/nrc.2017.94

Zhang et al. report that CD8+ tumour-infiltrating T lymphocytes exposed to a hypoglycaemic and hypoxic tumour microenvironment enhance PPARα signalling and fatty acid catabolism to partially preserve effector functions and increase the efficacy of immunotherapy in melanoma mouse models.



中文翻译:

免疫疗法:CD8 + T细胞-燃烧脂肪,变得健康

免疫疗法:CD8 + T细胞-燃烧脂肪,变得健康

Nature Reviews Cancer,在线发布:2017年10月6日; doi:10.1038 / nrc.2017.94

等人。报告指出,暴露于低血糖和低氧肿瘤微环境的CD8 +肿瘤浸润性T淋巴细胞可增强PPARα信号传导和脂肪酸分解代谢,从而部分保留效应子功能并提高黑色素瘤小鼠模型的免疫治疗效果。

更新日期:2017-10-11
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