Nature Reviews Immunology ( IF 100.3 ) Pub Date : 2017-10-09 , DOI: 10.1038/nri.2017.105 Venizelos Papayannopoulos
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our understanding of the role of neutrophils in pathogen clearance, immune regulation and disease pathology has advanced dramatically in recent years. Web-like chromatin structures known as neutrophil extracellular traps (NETs) have been at the forefront of this renewed interest in neutrophil biology. The identification of molecules that modulate the release of NETs has helped to refine our view of the role of NETs in immune protection, inflammatory and autoimmune diseases and cancer. Here, I discuss the key findings and concepts that have thus far shaped the field of NET biology.
中文翻译:
中性粒细胞胞外陷阱与免疫力和疾病的关系
中性粒细胞是先天性免疫吞噬细胞,在免疫防御中起重要作用。近年来,我们对嗜中性粒细胞在病原体清除,免疫调节和疾病病理学中的作用的了解已大大提高。网状染色质结构被称为嗜中性白细胞胞外诱捕器(NETs),一直是嗜中性白细胞生物学重新引起关注的最前沿。对调节NETs释放的分子的鉴定有助于完善我们对NETs在免疫保护,炎性和自身免疫性疾病以及癌症中作用的看法。在这里,我将讨论迄今为止已影响NET生物学领域的主要发现和概念。