Drug cargo on vitamin conjugates: Binding of two organometallic DNA–B₁₂ conjugates to the human vitamin B12-transporting proteins intrinsic factor, haptocorrin, and transcobalamin (TC) has been studied. Strong binding to TC is observed. This study supports the use of organometallic DNA–B₁₂ conjugates as vectors for the cellular delivery of single-stranded oligonucleotides upon parenteral administration.

中文翻译：

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有机金属DNA–B12结合作为潜在的寡核苷酸载体：人钴胺素转运蛋白的合成，结构和结合研究

维生素结合物上的药物货物：研究了两种有机金属DNA–B ₁₂结合物与人类维生素B12转运蛋白内在因子，结合蛋白和反钴胺素（TC）的结合。观察到与TC的强结合。这项研究支持使用有机金属DNA–B ₁₂偶联物作为载体，在肠胃外给药后用于细胞单链寡核苷酸的递送。