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Tumor Suppression by p53: Bring in the Hippo!
Cancer Cell ( IF 50.3 ) Pub Date : 2017-Oct-09 , DOI: 10.1016/j.ccell.2017.09.010
Yael Aylon , Moshe Oren

In this issue of Cancer Cell, Mello et al. investigated how p53 suppresses pancreatic cancer and discovered a key role for the tyrosine phosphatase PTPN14, a p53 transcriptional target. PTPN14 restrains YAP, curbing its potential oncogenic effects. The p53-PTPN14-YAP axis highlights the importance of signaling pathway coordination in cancer prevention.

中文翻译:

p53抑制肿瘤:带河马!

在本期《癌细胞》中,Mello等人。研究了p53如何抑制胰腺癌,并发现了酪氨酸磷酸酶PTPN14(p53转录靶标)的关键作用。PTPN14抑制了YAP,从而抑制了其潜在的致癌作用。p53-PTPN14-YAP轴突出了信号通路协调在癌症预防中的重要性。
更新日期:2017-10-09
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