Drug repositioning is hot, and much development time and money can be spared if one selects an old drug and explores the efficacy and safety in a new indication. Phenytoin is studied and repositioned in many disorders after the initial indication epilepsy (from 1937). Its repositioning in depression was put in the spotlight by the Wall Street icon Jack Dreyfus, already in the 1970s. Innovations in the field of phenytoin still appear to be possible for a number of indications such as wound healing, bipolar disorder and aggression, and via a topical formulation for neuropathic pain. We will discuss wound healing and identified a number of critical issues related to its repositioning in this indication.

药物重新定位很热，如果选择一种旧药物并在新适应症中探索功效和安全性，则可以节省大量的开发时间和金钱。对苯妥英钠进行了研究，并在最初的适应症癫痫发作后（从1937年开始）将其重新定位在许多疾病中。华尔街偶像杰克·德雷福斯（Jack Dreyfus）早在1970年代就将其在萧条中的重新定位放在了关注的焦点。对于许多适应症，例如伤口愈合，双相情感障碍和攻击，以及通过局部治疗神经性疼痛，苯妥英钠领域的创新似乎仍然是可能的。我们将讨论伤口的愈合，并在此适应症中确定与其重定位有关的许多关键问题。