当前位置: X-MOL 学术Annu. Rev. Cell Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Three-Dimensional Organization of Mammalian Genomes
Annual Review of Cell and Developmental Biology ( IF 11.3 ) Pub Date : 2017-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-100616-060531
Miao Yu 1 , Bing Ren 1, 2
Affiliation  

Animal development depends on not only the linear genome sequence that embeds millions of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that orchestrates the interplay between cis-regulatory elements and their target genes. Compared to our knowledge of the cis-regulatory sequences, the understanding of the 3D genome organization in human and other eukaryotes is still limited. Recent advances in technologies to map the 3D genome architecture have greatly accelerated the pace of discovery. Here, we review emerging concepts of chromatin organization in mammalian cells, discuss the dynamics of chromatin conformation during development, and highlight important roles for chromatin organization in cancer and other human diseases.

中文翻译:


哺乳动物基因组的三维组织

动物发育不仅取决于嵌入数百万个顺式调节元件的线性基因组序列,还取决于协调顺式调节元件与其靶基因之间相互作用的三维(3D)染色质结构。与我们对顺式调控序列的了解相比,对人类和其他真核生物的 3D 基因组组织的了解仍然有限。绘制 3D 基因组结构图的技术的最新进展极大地加快了发现的步伐。在这里,我们回顾了哺乳动物细胞中染色质组织的新兴概念,讨论了发育过程中染色质构象的动态,并强调了染色质组织在癌症和其他人类疾病中的重要作用。

更新日期:2017-10-06
down
wechat
bug