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Cell Polarity in Yeast
Annual Review of Cell and Developmental Biology ( IF 11.3 ) Pub Date : 2017-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-100616-060856
Jian-geng Chiou 1 , Mohan K. Balasubramanian 2 , Daniel J. Lew 1
Affiliation  

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in diverse organisms. Here we review findings from budding and fission yeasts that reveal both a conserved core polarity circuit and several adaptations that each organism exploits to fulfill the needs of its lifestyle. The core circuit involves positive feedback by local activation of Cdc42 to generate a cluster of concentrated GTP-Cdc42 at the membrane. Species-specific pathways regulate the timing of polarization during the cell cycle, as well as the location and number of polarity sites.

中文翻译:


酵母中的细胞极性

以Cdc42 GTPase为中心的保守分子机制可调节多种生物中的细胞极性。在这里,我们回顾了从发芽和裂变酵母中获得的发现,这些发现揭示了保守的核心极性回路以及每种生物体用来满足其生活方式需求的几种适应性。核心电路通过局部激活Cdc42来产生正反馈,从而在膜上产生浓缩的GTP-Cdc42簇。物种特异性途径调节细胞周期中极化的时间,以及极性位点的位置和数量。

更新日期:2017-10-06
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