A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated protein kinase (AMPK)-mediated anoikis, and consequently promotes PDAC development and metastasis.

中文翻译：

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胰管腺癌的代谢PON2zi方案崩溃。

胰腺导管腺癌（PDAC）细胞的标志是代谢重编程，可促进肿瘤进展。Nagarajan等人在分子细胞杂志（Molecular Cell）中发表的最新论文中。发现对氧磷酶（PON）2刺激葡萄糖转运蛋白（GLUT）1介导的葡萄糖摄取，阻止AMP激活的蛋白激酶（AMPK）介导的失神经，从而促进PDAC的发展和转移。