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E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion.
Cell Stem Cell ( IF 23.9 ) Pub Date : 2017-Oct-05 , DOI: 10.1016/j.stem.2017.09.013
Jiyung Shin , Jacob E. Corn

In this issue of Cell Stem Cell, Tothova et al. (2017) demonstrate a promising way to model the complex genetics of clonal hematopoiesis and myeloid disorders using CRISPR-Cas9 genome editing in human hematopoietic stem and progenitor cells. Their approach opens the door to genotype-specific pharmacologic testing.

中文翻译:

E Pluribus Unum(“众人皆是”):髓样扩展的CRISPR建模。

在本期《细胞干细胞》中,Tothova等人。(2017)展示了一种在人类造血干细胞和祖细胞中使用CRISPR-Cas9基因组编辑来建模克隆性造血和髓系疾病的复杂遗传学的有前途的方法。他们的方法为基因型特异性药理学检测打开了大门。
更新日期:2017-10-05
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