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Tonic NMDAR Currents in the Brain: Regulation and Cognitive Functions Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-13 Hayoung Kim, Sunyeong Choi, Euisun Lee, Wuhyun Koh, C. Justin Lee
Synaptically localized N-methyl-D-aspartate receptors (NMDARs) play a crucial role in important cognitive functions by mediating synaptic transmission and plasticity. In contrast, a tonic NMDAR current exists, thought to be mediated by extrasynaptic NMDARs, with a less clear function. This review provides a comprehensive overview of tonic NMDAR currents, focusing on their roles in synaptic transmission/plasticity
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Prefrontal regulation of social behavior and related deficits: insights from rodent studies Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-13 Nancy R. Mack, Nadia N. Bouras, Wen-Jun Gao
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing
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Reduced protein stability of 11 pathogenic missense STXBP1/MUNC18-1 variants and improved disease prediction Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-13 Timon André, Annemiek A. van Berkel, Gurdeep Singh, Esam T. Abualrous, Gaurav D. Diwan, Torsten Schmenger, Lara Braun, Jörg Malsam, Ruud F. Toonen, Christian Freund, Robert B. Russell, Matthijs Verhage, Thomas H. Söllner
Pathogenic variants in /Munc18-1 cause severe encephalopathies that are among the most common in genetic neurodevelopmental disorders. Different molecular disease mechanisms have been proposed and pathogenicity prediction is limited. This study aims to define a generalized disease concept for STXBP1-related disorders and improve prediction. A cohort of 11 disease-associated and five neutral variants
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Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-05 Alexandra B. Moussa-Tooks PhD, Adam Beermann MA, Karlos Manzanarez Felix BS, Michael Coleman MA, Sylvain Bouix PhD, Daphne Holt MD PhD, Kathryn E. Lewandowski PhD, Dost Öngür MD PhD, Alan Breier MD, Martha E. Shenton PhD, Stephan Heckers MD MSc, Sebastian Walther MD, Roscoe O. Brady Jr. MD PhD, Heather Burrell Ward MD
Psychomotor disturbances are observed across psychiatric disorders and often present as psychomotor slowing, agitation, disorganized behavior, or catatonia. Psychomotor function includes both cognitive and motor components, but the neural circuits driving these subprocesses and how they relate to symptoms have remained elusive for centuries. We analyzed data from the Human Connectome Project for Early
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The causal relationship between gut microbiota, brain volume, and intelligence: a two-step Mendelian randomization analysis Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-01 Shi Yao, Ji-Zhou Han, Jing Guo, Xin Wang, Long Qian, Hao Wu, Wei Shi, Ren-Jie Zhu, Jia-Hao Wang, Shan-Shan Dong, Li-Li Cui, Yan Wang, Yan Guo, Tie-Lin Yang
Growing evidence indicates that dynamic changes in gut microbiome can affect intelligence; however, whether these relationships are causal remains elusive. We aimed to disentangle the poorly understood causal relationship between gut microbiota and intelligence. We performed a two-sample Mendelian randomization (MR) analysis using genetic variants from the largest available genome-wide association
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Prefrontal-Limbic Circuitry is Associated with Reward Sensitivity in Nonhuman Primates Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-01 Kwang-Hyun Hur, Steven L. Meisler, Walid Yassin, Blaise B. Frederick, Stephen J. Kohut
Abnormal reward sensitivity is a risk factor for psychiatric disorders, including eating disorders such as overeating and binge-eating disorder, but the brain structural mechanisms underlying it are not completely understood. Here, we sought to investigate the relationship between multi-modal whole-brain structural features and reward sensitivity in nonhuman primates. Reward sensitivity was evaluated
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USING ELECTRONIC HEALTH RECORDS TO FACILITATE PRECISION PSYCHIATRY Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-24 Dominic Oliver, Maite Arribas, Benjamin I. Perry, Daniel Whiting, Graham Blackman, Kamil Krakowski, Aida Seyedsalehi, Emanuele F. Osimo, Siân Lowri Griffiths, Daniel Stahl, Andrea Cipriani, Seena Fazel, Paolo Fusar-Poli, Philip McGuire
The use of clinical prediction models to produce individualised risk estimates can facilitate the implementation of precision psychiatry. As a source of data from large, clinically representative patient samples, electronic health records (EHRs) provide a platform to develop and validate clinical prediction models, as well as potentially implementing them in routine clinical care. The present review
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Diffusion MRI tractography guides investigation of the zona incerta: a novel target for deep brain stimulation Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-22 Sabir Saluja, Liming Qiu, Allan R. Wang, Gustavo Campos, Robert Seilheimer, Jennifer A. McNab, Suzanne N. Haber, Daniel A.N. Barbosa, Casey H. Halpern
The zona incerta (ZI) is a subcortical structure primarily investigated in rodents, that is implicated in various behaviors from motor control to survival-associated activities, partly due to its integration in multiple neural circuits. In our study, we used diffusion MRI tractography to segment the ZI and gain insight into its connectivity in various circuits in humans. We performed probabilistic
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Acute stress increases striatal connectivity with cortical regions enriched for μ- and κ-opioid receptors Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-22 Peter Zhukovsky, Maria Ironside, Jessica M. Duda, Amelia D. Moser, Kaylee E. Null, Maeva Dhaynaut, Marc Normandin, Nicolas J. Guehl, Georges El Fakhri, Madeline Alexander, Laura M. Holsen, Madhusmita Misra, Rajesh Narendran, Jocelyn Hoye, Evan Morris, Shiba M. Esfand, Jill M. Goldstein, Diego A. Pizzagalli
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A metabolome-wide Mendelian randomization study identifies dysregulated arachidonic acid synthesis as a potential causal risk factor for bipolar disorder Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-22 David Stacey, Beben Benyamin, S Hong Lee, Elina Hyppönen
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Current State of the Art of Transcranial Magnetic Stimulation in Psychiatry: Innovations and Challenges for the Future Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-19 Odile A. van den Heuvel, Lindsay M. Oberman
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Accelerated Theta Burst Stimulation: Safety, Efficacy, and Future Advancements Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-19 Eleanor Cole, Sean J. O’Sullivan, Martin Tik, Nolan R. Williams
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Society of Biological Psychiatry’s 2024 Meeting Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-18 Victoria Arrango, Gerard Sanacora
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The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-10 Mariah F. Hazlett, Victoria L. Hall, Esha Patel, Aaron Halvorsen, Nicole Calakos, Anne E. West
Experience-dependent functional adaptation of nucleus accumbens (NAc) circuitry underlies the development and expression of reward-motivated behaviors. Parvalbumin-expressing GABAergic interneurons (PVINs) within the NAc are required for this process. Perineuronal nets (PNNs) are extracellular matrix structures enriched around PVINs that arise during development and are proposed to mediate brain circuit
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Specific patterns of endogenous functional connectivity are associated with harm avoidance in OCD Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-07 Merage Ghane, Lucas Trambaiolli, Michele A. Bertocci, Freddyson J. Martinez-Rivera, Henry W. Chase, Tyler Brady, Alex Skeba, Simona Graur, Lisa Bonar, Satish Iyengar, Gregory J. Quirk, Steven A. Rasmussen, Suzanne N. Haber, Mary L. Phillips
Individuals with OCD show persistent-avoidance behaviors, often in the absence of actual threat. Quality-of-life costs and heterogeneity support the need for novel brain-behavior intervention targets. Informed by mechanistic and anatomic studies of persistent-avoidance in rodents and non-human primates, our goal was to test whether connections within a hypothesized persistent-avoidance related network
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Posterior Cerebellar Resting-State Functional Hypoconnectivity: A Neural Marker of Schizophrenia across Different Stages of Treatment Response Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-07 Urvakhsh Meherwan Mehta, Dhruva Ithal, Neelabja Roy, Shreshth Shekhar, Ramajayam Govindaraj, Chaitra T. Ramachandraiah, Nicolas R. Bolo, Rose Dawn Bharath, Jagadisha Thirthalli, Ganesan Venkatasubramanian, Bangalore N. Gangadhar, Matcheri S. Keshavan
Identifying stable and consistent resting-state functional connectivity (rsFC) patterns across illness trajectories has the potential to be considered fundamental to the pathophysiology of schizophrenia. We aimed to identify consistent rsFC patterns across heterogeneous schizophrenia groups defined based on treatment response. In phase-1, we used a cross-sectional, case-control design to characterize
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Ultrahigh-Field Magnetic Resonance Spectroscopy Findings Do Not Support Previous Brain Metabolite Findings in Major Depressive Disorder Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-05 Amanda J.F. Tamman, Chadi G. Abdallah
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Two Distinct Biotypes in Major Depression Unveiled Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-05 Rammohan Shukla
Abstract not available
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A New Look at Gray Matter Decreases in Chronic Pain Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-05 Tor D. Wager, Katerina Zorina-Lichtenwalter, Naomi P. Friedman
Abstract not available
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Frontal norepinephrine represents a threat prediction error under uncertainty Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-04 Aakash Basu, Jen-Hau Yang, Abigail Yu, Samira Glaeser-Khan, Jocelyne A. Rondeau, Jiesi Feng, John H. Krystal, Yulong Li, Alfred P. Kaye
Background To adapt to threats in the environment, animals must predict them and engage in defensive behavior. While the representation of a prediction error signal for reward has been linked to dopamine, a neuromodulatory prediction error for aversive learning has not been identified. Methods Here, we measured and manipulated norepinephrine release during threat learning using optogenetics and a novel
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Transcriptional Patterns of Brain Structural Covariance Network Abnormalities Associated with Suicidal Thoughts and Behaviors in Major Depressive Disorder Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-04 Kun Qin, Huiru Li, Huawei Zhang, Li Yin, Baolin Wu, Nanfang Pan, Taolin Chen, Neil Roberts, John A. Sweeney, Xiaoqi Huang, Qiyong Gong, Zhiyun Jia
Background Although brain structural covariance network (SCN) abnormalities were associated with suicidal thoughts and behaviors (STB) in individuals with major depressive disorder (MDD), previous studies reported inconsistent findings based on small sample size and underlying transcriptional patterns remained poorly understood. Methods Using a multicenter MRI dataset including 218 MDD patients with
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Long-term impact of early life stress on serotonin connectivity Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-03 Raksha Ramkumar, Moriah Edge-Partington, Dylan J. Terstege, Kabirat Adigun, Yi Ren, Nazmus S. Khan, Nahid Rouhi, Naila F. Jamani, Mio Tsutsui, Jonathan R. Epp, Derya Sargin
Chronic childhood stress is a prominent risk factor for developing affective disorders, yet mechanisms underlying this association remain unclear. Maintenance of optimal serotonin (5-HT) levels during early postnatal development is critical for the maturation of brain circuits. Understanding the long-lasting effects of early life stress (ELS) on serotonin-modulated brain connectivity is crucial to
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Nucleus Basalis of Meynert degeneration predicts cognitive decline in Corticobasal Syndrome Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-02 Daniele Urso, Salvatore Nigro, Benedetta Tafuri, Roberto De Blasi, Joana B. Pereira, Giancarlo Logroscino
Cognitive changes are common in corticobasal syndrome (CBS) and significantly impact quality of life and caregiver burden. However, there is a scarcity of studies investigating the neural substrates of cognitive changes in CBS, and currently, reliable predictors of cognitive impairment are lacking. The nucleus basalis of Meynert (NbM), which serves as the primary source of cortical cholinergic innervation
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Reduction of aversive learning rates in Pavlovian conditioning by angiotensin II antagonist losartan: a randomised controlled trial Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-02 Ondrej Zika, Judith Appel, Corinna Klinge, Lorika Shkreli, Michael Browning, Katja Wiech, Andrea Reinecke
Angiotensin receptor blockade (ARB) has been linked to aspects of aversive learning and memory formation, and to the prevention of post-traumatic stress disorder symptom development. We investigate the influence of the ARB losartan on aversive Pavlovian conditioning using a probabilistic learning paradigm. In a double-blind, randomised placebo-controlled design, we tested 45 (18 female) healthy volunteers
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Imaging the Vesicular Acetylcholine Transporter in Schizophrenia: a PET study using [18F]-VAT Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-02 Jodi J. Weinstein, Scott J. Moeller, Greg Perlman, Roberto Gil, Jared X. Van Snellenberg, Kenneth Wengler, Jiayan Meng, Mark Slifstein, Anissa Abi-Dargham
Despite longstanding interest in the central cholinergic system in schizophrenia, cholinergic imaging studies in patients have been limited to receptors. Here, we conducted a proof-of-concept positron emission tomography (PET) study using [F]-VAT, a new radiotracer which targets the vesicular acetylcholine transporter (VAChT) as a proxy measure of acetylcholine transmission capacity, in patients with
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What Is Mental Effort: A Clinical Perspective Biol. Psychiatry (IF 10.6) Pub Date : 2024-02-01 Noham Wolpe, Richard Holton, Paul C. Fletcher
Although mental effort is a frequently used term, it is poorly defined and understood. Consequently, its usage is frequently loose and potentially misleading. In neuroscience research, the term is used to mean both the cognitive work that is done to meet task demands and the subjective experience of performing that work. We argue that conflating these two meanings hampers progress in understanding
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Evidence for Locus Coeruleus–Norepinephrine System Abnormality in Military Posttraumatic Stress Disorder Revealed by Neuromelanin-Sensitive Magnetic Resonance Imaging Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-29 Adelina McCall, Reihaneh Forouhandehpour, Seyda Celebi, Claude Richard-Malenfant, Rami Hamati, Synthia Guimond, Lauri Tuominen, David Weinshenker, Natalia Jaworska, Robyn J. McQuaid, Jakov Shlik, Rebecca Robillard, Zachary Kaminsky, Clifford M. Cassidy
The complex neurobiology of posttraumatic stress disorder (PTSD) calls for the characterization of specific disruptions in brain functions that require targeted treatment. One such alteration could be an overactive locus coeruleus (LC)–norepinephrine system, which may be linked to hyperarousal symptoms, a characteristic and burdensome aspect of the disorder. Study participants were Canadian Armed Forces
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Dimensional and Categorical Solutions to Parsing Depression Heterogeneity in a Large Single-Site Sample Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-26 Katharine Dunlop, Logan Grosenick, Jonathan Downar, Fidel Vila-Rodriguez, Faith M. Gunning, Zafiris J. Daskalakis, Daniel M. Blumberger, Conor Liston
Background Recent studies have reported significant advances in modeling the biological basis of heterogeneity in major depressive disorder (MDD), but investigators have also identified important technical challenges, including scanner-related artifacts, a propensity for multivariate models to overfit, and a need for larger samples with more extensive clinical phenotyping. The goals of this work were
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Higher-Order Intrinsic Brain Network Trajectories After Antipsychotic Treatment in Medication-Naïve Patients With First-Episode Psychosis Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-24 Jose O. Maximo, William P. Armstrong, Nina V. Kraguljac, Adrienne C. Lahti
Intrinsic brain network connectivity is already altered in first-episode psychosis (FEP), but the longitudinal trajectories of network connectivity, especially in response to antipsychotic treatment, remain poorly understood. The goal of this study was to investigate how antipsychotic medications affect higher-order intrinsic brain network connectivity in FEP. Data from 87 antipsychotic medication-naïve
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Sex-Specific Vulnerability to Externalizing Problems: Sensitivity to Early Stress and Nucleus Accumbens Activation Over Adolescence Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-24 Lauren R. Borchers, Justin P. Yuan, Josiah K. Leong, Booil Jo, Rajpreet Chahal, Joshua Ryu, Andrew Nam, Saché M. Coury, Ian H. Gotlib
Exposure and sensitivity to early-life stress (ELS) are related to increased risk for psychopathology in adolescence. While cross-sectional studies have reported blunted nucleus accumbens (NAcc) activation in the context of these associations, researchers have not yet assessed the effects of ELS on developmental trajectories of activation. We examined whether trajectories are affected by stress and
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Neuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-23 Katrin H. Preller, Joachim Scholpp, Andreas Wunder, Holger Rosenbrock
Schizophrenia is a chronic mental illness that affects up to 1% of the population. While efficacious therapies are available for positive symptoms, effective treatment of cognitive and negative symptoms remains an unmet need after decades of research. New developments in the field of neuroimaging are accelerating our knowledge gain regarding the underlying pathophysiology of symptoms in schizophrenia
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Sensory attenuation deficit and auditory hallucinations in schizophrenia: a causal mechanism or a risk factor? Evidence from meta-analyses on N1 ERP-EEG component. Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-20 Marika Mariano, Ileana Rossetti, Angelo Maravita, Eraldo Paulesu, Laura Zapparoli
Background Sensory attenuation (SA), the dampened perception of self-generated sensory information, is typically associated with reduced ERP signals, like for the N1 component of auditory ERPs. SA, together with efficient monitoring of intentions and actions, should facilitate the distinction between self-generated and externally-generated sensory events, optimizing the interaction with the world.
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Individual Differences in Volitional Social Self-Administration and Motivation in Male and Female Mice Following Social Stress Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-18 Jovana Navarrete, Kevin N. Schneider, Briana M. Smith, Nastacia L. Goodwin, Yizhe Y. Zhang, Axelle S. Salazar, Yahir E. Gonzalez, Pranav Anumolu, Ethan Gross, Valerie S. Tsai, Mitra Heshmati, Sam A. Golden
A key challenge in developing treatments for neuropsychiatric illness is the disconnect between preclinical models and the complexity of human social behavior. We integrate voluntary social self-administration into a rodent model of social stress as a platform for the identification of fundamental brain and behavior mechanisms underlying stress-induced individual differences in social motivation. Here
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Disrupted Maturation of White Matter Microstructure After Concussion Is Associated With Internalizing Behavior Scores in Female Children Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-16 Eman Nishat, Shannon E. Scratch, Stephanie H. Ameis, Anne L. Wheeler
Some children who experience concussions, particularly females, develop long-lasting emotional and behavioral problems. Establishing the potential contribution of preexisting behavioral problems and disrupted white matter maturation has been challenging due to a lack of preinjury data. From the Adolescent Brain Cognitive Development cohort, 239 (90 female) children age 12.1 ± 0.6 years who experienced
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The Microbiome at the Interface of the Exposome and Risk for Psychiatric Disorders Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-12 Tamar L. Gur, Elaine Y. Hsaio
Abstract not available
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Individualized Texture Similarity Network in Schizophrenia Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-12 Hao Ding, Yu Zhang, Yingying Xie, Xiaotong Du, Yi Ji, Liyuan Lin, Zhongyu Chang, Bin Zhang, Meng Liang, Chunshui Yu, Wen Qin
Structural covariance network disruption has been considered an important pathophysiological indicator for schizophrenia. Here, we introduced a novel individualized structural covariance network measure, referred to as a texture similarity network (TSN), and hypothesized that the TSN could reliably reveal unique intersubject heterogeneity and complex dysconnectivity patterns in schizophrenia. The TSN
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Brain Structural and Functional Damage Network Localization of Suicide Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-10 Xiaohan Zhang, Ruoxuan Xu, Haining Ma, Yinfeng Qian, Jiajia Zhu
Extensive neuroimaging research on brain structural and functional correlates of suicide has produced inconsistent results. Despite increasing recognition that damage in multiple different brain locations that causes the same symptom can map to a common brain network, there is still a paucity of research investigating network localization of suicide. To clarify this issue, we initially identified brain
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Irritable Bowel Syndrome Is Associated With Brain Health by Neuroimaging, Behavioral, Biochemical, and Genetic Analyses Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-08 Zeyu Li, Qing Ma, Yueting Deng, Edmund T. Rolls, Chun Shen, Yuzhu Li, Wei Zhang, Shitong Xiang, Christelle Langley, Barbara J. Sahakian, Trevor W. Robbins, Jin-Tai Yu, Jianfeng Feng, Wei Cheng
Irritable bowel syndrome (IBS) interacts with psychopathology in a complex way; however, little is known about the underlying brain, biochemical, and genetic mechanisms. To clarify the phenotypic and genetic associations between IBS and brain health, we performed a comprehensive retrospective cohort study on a large population. Our study included 171,104 participants from the UK Biobank who underwent
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How real-world data can facilitate the development of precision medicine treatment in psychiatry Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-05 Elise Koch, Antonio F. Pardiñas, Kevin S. O’Connell, Pierluigi Selvaggi, José Camacho Collados, Aleksandar Babic, Serena E. Marshall, Erik Van der Eycken, Cecilia Angulo, Yi Lu, Patrick F. Sullivan, Anders M. Dale, Espen Molden, Danielle Posthuma, Nathan White, Alexander Schubert, Srdjan Djurovic, Hakon Heimer, Hreinn Stefánsson, Kári Stefánsson, Ole A. Andreassen
Precision medicine has the ambition to improve treatment response and clinical outcomes through patient stratification, and holds great potential in mental disorders. However, several important factors are needed to transform current practice into a “precision psychiatry” framework. Most important are (1) the generation of accessible large real-world training and test data including genomic data integrated
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Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-06 Devon Stoliker, Leonardo Novelli, Franz X. Vollenweider, Gary F. Egan, Katrin H. Preller, Adeel Razi
Serotonergic psychedelics, such as psilocybin, alter perceptual and cognitive systems that are functionally integrated with the amygdala. These changes can alter cognition and emotions that are hypothesized to contribute to their therapeutic utility. However, the neural mechanisms of cognitive and subcortical systems altered by psychedelics are not well understood. We used resting-state functional
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Immune Cell Alterations in Psychotic Disorders: A Comprehensive Systematic Review and Meta-Analysis Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-06 Max Clausen, Rune H.B. Christensen, Maria da Re, Michael E. Benros
A comprehensive meta-analysis on the composition of circulating immune cells from both the myeloid and the lymphoid lines including specialized subsets in blood and cerebrospinal fluid (CSF) of patients with psychotic disorders compared with healthy control participants has been lacking. Multiple databases (PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov, and PsycINFO) were searched
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Evening Chronotypes With Depression Report Poorer Outcomes of Selective Serotonin Reuptake Inhibitors: A Survey-Based Study of Self-Ratings Biol. Psychiatry (IF 10.6) Pub Date : 2024-01-05 Jacob J. Crouse, Shin Ho Park, Enda M. Byrne, Brittany L. Mitchell, Karina Chan, Jan Scott, Sarah E. Medland, Nicholas G. Martin, Naomi R. Wray, Ian B. Hickie
Preliminary evidence suggests that evening chronotype is related to poorer efficacy of selective serotonin reuptake inhibitors. It is unknown whether this is specific to particular medications, self-rated chronotype, or efficacy. In the Australian Genetics of Depression Study ( = 15,108; 75% women; 18–90 years; 68% with ≥1 other lifetime diagnosis), a survey recorded experiences with 10 antidepressants
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