显示样式:     当前期刊: Nature Reviews Nephrology    加入关注    导出
我的关注
我的收藏
您暂时未登录!
登录
  • Regenerative medicine: A step closer to kidneys in a dish
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-20
    Grant Otto

    Regenerative medicine: A step closer to kidneys in a dish Regenerative medicine: A step closer to kidneys in a dish, Published online: 20 November 2017; doi:10.1038/nrneph.2017.162

    更新日期:2017-11-20
  • Epigenetics: EWAS of kidney function
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-20
    Jack M. Heintze

    Epigenetics: EWAS of kidney function Epigenetics: EWAS of kidney function, Published online: 20 November 2017; doi:10.1038/nrneph.2017.164

    更新日期:2017-11-20
  • Gene expression: Single-cell RNA sequencing of collecting duct cells
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-20
    Susan J. Allison

    Gene expression: Single-cell RNA sequencing of collecting duct cells Gene expression: Single-cell RNA sequencing of collecting duct cells, Published online: 20 November 2017; doi:10.1038/nrneph.2017.163

    更新日期:2017-11-20
  • Regenerative medicine: A step closer to kidneys in a dish
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-20
    Grant Otto

    Regenerative medicine: A step closer to kidneys in a dish Regenerative medicine: A step closer to kidneys in a dish, Published online: 20 November 2017; doi:10.1038/nrneph.2017.162

    更新日期:2017-11-20
  • Epigenetics: EWAS of kidney function
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-20
    Jack M. Heintze

    Epigenetics: EWAS of kidney function Epigenetics: EWAS of kidney function, Published online: 20 November 2017; doi:10.1038/nrneph.2017.164

    更新日期:2017-11-20
  • Gene expression: Single-cell RNA sequencing of collecting duct cells
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-20
    Susan J. Allison

    Gene expression: Single-cell RNA sequencing of collecting duct cells Gene expression: Single-cell RNA sequencing of collecting duct cells, Published online: 20 November 2017; doi:10.1038/nrneph.2017.163

    更新日期:2017-11-20
  • Hypertension: Device therapy for uncontrolled hypertension: new approaches to an old problem
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-15
    Peter J. Blankestijn, Michiel L. Bots

    Hypertension: Device therapy for uncontrolled hypertension: new approaches to an old problemHypertension: Device therapy for uncontrolled hypertension: new approaches to an old problem, Published online: 15 November 2017; doi:10.1038/nrneph.2017.150NatureArticleSnippet(type=standfirst, markup=Uncontrolled hypertension is an important clinical problem and is associated with considerable morbidity and mortality. A new report from the SPYRAL HTN-OFF MED researchers, which describes the use of renal denervation in patients with uncontrolled hypertension, might reignite enthusiasm for this technique, while a first-in-human description of endovascular baroreflex amplification from the CALM-FIM_EUR investigators highlights the potential of this new approach to inhibit sympathetic activity., isJats=true)

    更新日期:2017-11-15
  • Hypertension: Device therapy for uncontrolled hypertension: new approaches to an old problem
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-15
    Peter J. Blankestijn, Michiel L. Bots

    Hypertension: Device therapy for uncontrolled hypertension: new approaches to an old problemHypertension: Device therapy for uncontrolled hypertension: new approaches to an old problem, Published online: 15 November 2017; doi:10.1038/nrneph.2017.150NatureArticleSnippet(type=standfirst, markup=Uncontrolled hypertension is an important clinical problem and is associated with considerable morbidity and mortality. A new report from the SPYRAL HTN-OFF MED researchers, which describes the use of renal denervation in patients with uncontrolled hypertension, might reignite enthusiasm for this technique, while a first-in-human description of endovascular baroreflex amplification from the CALM-FIM_EUR investigators highlights the potential of this new approach to inhibit sympathetic activity., isJats=true)

    更新日期:2017-11-15
  • Hypertension: Peripheral control of the systemic hypoxic response
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Grant Otto

    Hypertension: Peripheral control of the systemic hypoxic response Hypertension: Peripheral control of the systemic hypoxic response, Published online: 13 November 2017; doi:10.1038/nrneph.2017.160

    更新日期:2017-11-13
  • Nephrotic syndrome: AVIL mutations reduce podocyte migration rate in SRNS
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Jack M. Heintze

    Nephrotic syndrome: AVIL mutations reduce podocyte migration rate in SRNS Nephrotic syndrome: AVIL mutations reduce podocyte migration rate in SRNS, Published online: 13 November 2017; doi:10.1038/nrneph.2017.158

    更新日期:2017-11-13
  • The neural basis of homeostatic and anticipatory thirst
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Claire Gizowski, Charles W. Bourque

    The neural basis of homeostatic and anticipatory thirst The neural basis of homeostatic and anticipatory thirst, Published online: 13 November 2017; doi:10.1038/nrneph.2017.149 NatureArticleSnippet(type=short-summary, markup= The perception of thirst is critical for the control of body fluid homeostasis. In this Review, Gizowski and Bourque discuss the importance of thirst for body fluid balance and describe the central neural networks that regulate thirst, including adaptive changes to systemic processes and feedforward anticipatory responses that precede physiological challenges to maintain body fluid balance. , isJats=true)

    更新日期:2017-11-13
  • Tubular disease: Anti-LRP2 nephropathy
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Ellen F. Carney

    Tubular disease: Anti-LRP2 nephropathy Tubular disease: Anti-LRP2 nephropathy, Published online: 13 November 2017; doi:10.1038/nrneph.2017.159

    更新日期:2017-11-13
  • Hypertension: Peripheral control of the systemic hypoxic response
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Grant Otto

    Hypertension: Peripheral control of the systemic hypoxic response Hypertension: Peripheral control of the systemic hypoxic response, Published online: 13 November 2017; doi:10.1038/nrneph.2017.160

    更新日期:2017-11-13
  • Nephrotic syndrome: AVIL mutations reduce podocyte migration rate in SRNS
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Jack M. Heintze

    Nephrotic syndrome: AVIL mutations reduce podocyte migration rate in SRNS Nephrotic syndrome: AVIL mutations reduce podocyte migration rate in SRNS, Published online: 13 November 2017; doi:10.1038/nrneph.2017.158

    更新日期:2017-11-13
  • The neural basis of homeostatic and anticipatory thirst
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Claire Gizowski, Charles W. Bourque

    The neural basis of homeostatic and anticipatory thirst The neural basis of homeostatic and anticipatory thirst, Published online: 13 November 2017; doi:10.1038/nrneph.2017.149 NatureArticleSnippet(type=short-summary, markup= The perception of thirst is critical for the control of body fluid homeostasis. In this Review, Gizowski and Bourque discuss the importance of thirst for body fluid balance and describe the central neural networks that regulate thirst, including adaptive changes to systemic processes and feedforward anticipatory responses that precede physiological challenges to maintain body fluid balance. , isJats=true)

    更新日期:2017-11-13
  • Tubular disease: Anti-LRP2 nephropathy
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-13
    Ellen F. Carney

    Tubular disease: Anti-LRP2 nephropathy Tubular disease: Anti-LRP2 nephropathy, Published online: 13 November 2017; doi:10.1038/nrneph.2017.159

    更新日期:2017-11-13
  • Chronic kidney disease: Intensive blood pressure reduction lowers mortality in CKD
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-07
    Stephen P. Juraschek, Lawrence J. Appel

    Chronic kidney disease: Intensive blood pressure reduction lowers mortality in CKDChronic kidney disease: Intensive blood pressure reduction lowers mortality in CKD, Published online: 07 November 2017; doi:10.1038/nrneph.2017.154NatureArticleSnippet(type=standfirst, markup=Hypertension is a risk factor for chronic kidney disease (CKD), but the optimal blood pressure (BP) target in patients with stage 3–5 CKD is unclear. Now, a meta-analysis reports that more-intensive BP control is associated with a reduced risk of all-cause mortality compared with less-intensive BP goals in this high-risk population., isJats=true)

    更新日期:2017-11-07
  • Chronic kidney disease: Intensive blood pressure reduction lowers mortality in CKD
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-07
    Stephen P. Juraschek, Lawrence J. Appel

    Chronic kidney disease: Intensive blood pressure reduction lowers mortality in CKDChronic kidney disease: Intensive blood pressure reduction lowers mortality in CKD, Published online: 07 November 2017; doi:10.1038/nrneph.2017.154NatureArticleSnippet(type=standfirst, markup=Hypertension is a risk factor for chronic kidney disease (CKD), but the optimal blood pressure (BP) target in patients with stage 3–5 CKD is unclear. Now, a meta-analysis reports that more-intensive BP control is associated with a reduced risk of all-cause mortality compared with less-intensive BP goals in this high-risk population., isJats=true)

    更新日期:2017-11-07
  • Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Michael L. Merchant, Ilse M. Rood, Jeroen K. J. Deegens, Jon B. Klein

    Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.148 Extracellular vesicles in the urine have potential as disease biomarkers. This Review discusses the different types of extracellular vesicles and the optimization of approaches to enable their isolation and purification, and to characterize their composition by high-throughput 'omics' technologies.

    更新日期:2017-10-30
  • Genetic kidney disease: Uromodulin in ER stress and apoptosis
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Susan J. Allison

    Genetic kidney disease: Uromodulin in ER stress and apoptosis Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.152

    更新日期:2017-10-30
  • Developmental biology: Renewal of NPCs requires MYC and β-catenin
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Jack M. Heintze

    Developmental biology: Renewal of NPCs requires MYC and β-catenin Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.151

    更新日期:2017-10-30
  • Podocytes: ShcA regulates nephrin turnover
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Ellen F. Carney

    Podocytes: ShcA regulates nephrin turnover Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.153

    更新日期:2017-10-30
  • Modelling diabetic nephropathy in mice
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-24
    Kengo Azushima, Susan B. Gurley, Thomas M. Coffman

    Modelling diabetic nephropathy in mice Nature Reviews Nephrology, Published online: 24 October 2017; doi:10.1038/nrneph.2017.142 Animal models that faithfully recapitulate human diabetic nephropathy (DN) are needed to study disease pathogenesis, identify drug targets and test new therapies. Here, the authors review progress in developing mouse models of DN, the limitations of current models, and opportunities for future development.

    更新日期:2017-10-30
  • Immunometabolism: Oxygen sensing and cell metabolism in inflammation
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-24
    Kai-Uwe Eckardt

    Immunometabolism: Oxygen sensing and cell metabolism in inflammation Nature Reviews Nephrology, Published online: 24 October 2017; doi:10.1038/nrneph.2017.145 Hypoxia-inducible transcription factors (HIFs) are key mediators of several molecular and cellular responses that are activated under hypoxic conditions. New findings demonstrate an important role for the HIF system in mediating the activation and inflammatory responses of neutrophils through tight interaction with their glucose metabolism.

    更新日期:2017-10-30
  • Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Michael L. Merchant, Ilse M. Rood, Jeroen K. J. Deegens, Jon B. Klein

    Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.148 Extracellular vesicles in the urine have potential as disease biomarkers. This Review discusses the different types of extracellular vesicles and the optimization of approaches to enable their isolation and purification, and to characterize their composition by high-throughput 'omics' technologies.

    更新日期:2017-10-30
  • Genetic kidney disease: Uromodulin in ER stress and apoptosis
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Susan J. Allison

    Genetic kidney disease: Uromodulin in ER stress and apoptosis Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.152

    更新日期:2017-10-30
  • Developmental biology: Renewal of NPCs requires MYC and β-catenin
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Jack M. Heintze

    Developmental biology: Renewal of NPCs requires MYC and β-catenin Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.151

    更新日期:2017-10-30
  • Podocytes: ShcA regulates nephrin turnover
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-30
    Ellen F. Carney

    Podocytes: ShcA regulates nephrin turnover Nature Reviews Nephrology, Published online: 30 October 2017; doi:10.1038/nrneph.2017.153

    更新日期:2017-10-30
  • Modelling diabetic nephropathy in mice
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-24
    Kengo Azushima, Susan B. Gurley, Thomas M. Coffman

    Modelling diabetic nephropathy in mice Nature Reviews Nephrology, Published online: 24 October 2017; doi:10.1038/nrneph.2017.142 Animal models that faithfully recapitulate human diabetic nephropathy (DN) are needed to study disease pathogenesis, identify drug targets and test new therapies. Here, the authors review progress in developing mouse models of DN, the limitations of current models, and opportunities for future development.

    更新日期:2017-10-30
  • Immunometabolism: Oxygen sensing and cell metabolism in inflammation
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-10-24
    Kai-Uwe Eckardt

    Immunometabolism: Oxygen sensing and cell metabolism in inflammation Nature Reviews Nephrology, Published online: 24 October 2017; doi:10.1038/nrneph.2017.145 Hypoxia-inducible transcription factors (HIFs) are key mediators of several molecular and cellular responses that are activated under hypoxic conditions. New findings demonstrate an important role for the HIF system in mediating the activation and inflammatory responses of neutrophils through tight interaction with their glucose metabolism.

    更新日期:2017-10-30
  • B cells in type 1 diabetes mellitus and diabetic kidney disease
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-01
    Mia J. Smith, Kimber M. Simmons, John C. Cambier

    B cells in type 1 diabetes mellitus and diabetic kidney disease Nature Reviews Nephrology, Published online: 17 October 2017; doi:10.1038/nrneph.2017.138 An increasing body of evidence supports a role for B cells in the pathogenesis of type 1 diabetes mellitus (T1DM). Here, the authors discuss the mechanisms and consequences of B cell activation in T1DM and how these cells might contribute to the development of diabetic kidney disease.

    更新日期:2017-10-17
  • B cells in type 1 diabetes mellitus and diabetic kidney disease
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 2017-11-01
    Mia J. Smith, Kimber M. Simmons, John C. Cambier

    B cells in type 1 diabetes mellitus and diabetic kidney disease Nature Reviews Nephrology, Published online: 17 October 2017; doi:10.1038/nrneph.2017.138 An increasing body of evidence supports a role for B cells in the pathogenesis of type 1 diabetes mellitus (T1DM). Here, the authors discuss the mechanisms and consequences of B cell activation in T1DM and how these cells might contribute to the development of diabetic kidney disease.

    更新日期:2017-10-17
  • Renal anaemia: iPSC-derived EPO-producing cells rescue anaemia
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Susan J. Allison

    Renal anaemia: iPSC-derived EPO-producing cells rescue anaemia Nature Reviews Nephrology, Published online: 16 October 2017; doi:10.1038/nrneph.2017.146

    更新日期:2017-10-16
  • Polycystic kidney disease: Modulation of cystogenesis by the microenviroment
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ellen F. Carney

    Polycystic kidney disease: Modulation of cystogenesis by the microenviroment Nature Reviews Nephrology, Published online: 16 October 2017; doi:10.1038/nrneph.2017.147

    更新日期:2017-10-16
  • Renal anaemia: iPSC-derived EPO-producing cells rescue anaemia
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Susan J. Allison

    Renal anaemia: iPSC-derived EPO-producing cells rescue anaemia Nature Reviews Nephrology, Published online: 16 October 2017; doi:10.1038/nrneph.2017.146

    更新日期:2017-10-16
  • Polycystic kidney disease: Modulation of cystogenesis by the microenviroment
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ellen F. Carney

    Polycystic kidney disease: Modulation of cystogenesis by the microenviroment Nature Reviews Nephrology, Published online: 16 October 2017; doi:10.1038/nrneph.2017.147

    更新日期:2017-10-16
  • Renal physiology: ER-associated degradation in diabetes insipidus
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Susan J. Allison

    Renal physiology: ER-associated degradation in diabetes insipidus Nature Reviews Nephrology, Published online: 9 October 2017; doi:10.1038/nrneph.2017.144

    更新日期:2017-10-11
  • New treatment paradigms for ADPKD: moving towards precision medicine
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Matthew B. Lanktree, Arlene B. Chapman

    The natural history of autosomal dominant polycystic kidney disease (ADPKD) is characterized by a variable rate of cyst development and increase in total kidney volume (TKV), variable kidney function decline and age of onset of end-stage renal disease (ESRD), and variable presentation of renal and extrarenal manifestations. Precision medicine is proposed to improve patient outcomes by tailoring therapy to the specific genetic background, pathophysiology, disease burden, prognosis and status of each individual. This approach to the management of patients with ADPKD is nearing clinical implementation owing to advances in genetics, imaging, biomarker development and therapeutics. In this Review, we discuss pharmacological and non-pharmacological interventions for the treatment of hypertension and proteinuria, and for slowing the rate of cyst growth in patients with ADPKD before the development of ESRD. We provide recommendations for the management of renal complications, including cyst infection, nephrolithiasis, haematuria and chronic pain. The early treatment of patients with ADPKD who are largely asymptomatic is associated with a therapeutic burden but slows cyst growth and delays subsequent loss of kidney function, which ultimately delays the need for renal replacement therapy and has a positive effect on the quality of life of patients.

    更新日期:2017-10-11
  • Glomerular disease: Loss of Epas1 promotes FSGS
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Jack M. Heintze

    Glomerular disease: Loss of Epas1 promotes FSGS Nature Reviews Nephrology, Published online: 9 October 2017; doi:10.1038/nrneph.2017.143

    更新日期:2017-10-11
  • Diabetic nephropathy: Renoprotective effects of GLP1R agonists and SGLT2 inhibitors
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Berthold Hocher, Oleg Tsuprykov

    Diabetic nephropathy: Renoprotective effects of GLP1R agonists and SGLT2 inhibitors Nature Reviews Nephrology, Published online: 9 October 2017; doi:10.1038/nrneph.2017.140 New data from the LEADER trial show that the glucagon-like peptide 1 receptor agonist liraglutide protects against diabetic nephropathy in patients with type 2 diabetes mellitus. The renoprotective efficacy of liraglutide is not, however, as great as that reported for the sodium-glucose cotransporter 2 inhibitor emplagiflozin in the EMPA-REG OUTCOME trial.

    更新日期:2017-10-11
  • Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Andrey V. Cybulsky

    Progress has been made in our understanding of the mechanisms of endoplasmic reticulum (ER) proteostasis, ER stress and the unfolded protein response (UPR), as well as ER stress-induced autophagy, in the kidney. Experimental models have revealed that disruption of the UPR, including a protein that senses misfolded proteins (namely, inositol-requiring enzyme 1α) in mouse podocytes causes podocyte injury and albuminuria as mice age. Protein misfolding and ER stress are evident in various renal diseases, including primary glomerulonephritides, glomerulopathies associated with genetic mutations, diabetic nephropathy, acute kidney injury, chronic kidney disease and renal fibrosis. The induction of ER stress may be cytoprotective, or it may be cytotoxic by activating apoptosis. The UPR may interact in a coordinated manner with autophagy to alleviate protein misfolding and its consequences. Monitoring the excretion of ER chaperones into the urine can potentially serve as a biomarker of renal ER stress. In specific kidney diseases, the treatment of experimental animals with chemical chaperones that improve protein folding or with chaperone inducers has alleviated kidney injury. Given the limited availability of mechanism-based therapies for kidney diseases, normalization of ER stress using pharmacological agents represents a promising therapeutic approach towards preventing or arresting the progression of kidney disease.

    更新日期:2017-10-11
  • Epigenetics: Disturbed imprinting in pre-eclampsia
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ellen F. Carney

    Epigenetics: Disturbed imprinting in pre-eclampsia Nature Reviews Nephrology, Published online: 3 October 2017; doi:10.1038/nrneph.2017.141

    更新日期:2017-10-11
  • Targeting neural reflex circuits in immunity to treat kidney disease
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Mark D. Okusa, Diane L. Rosin, Kevin J. Tracey

    Neural pathways regulate immunity and inflammation via the inflammatory reflex and specific molecular targets can be modulated by stimulating neurons. Neuroimmunomodulation by nonpharmacological methods is emerging as a novel therapeutic strategy for inflammatory diseases, including kidney diseases and hypertension. Electrical stimulation of vagus neurons or treatment with pulsed ultrasound activates the cholinergic anti-inflammatory pathway (CAP) and protects mice from acute kidney injury (AKI). Direct innervation of the kidney, by afferent and efferent neurons, might have a role in modulating and responding to inflammation in various diseases, either locally or by providing feedback to regions of the central nervous system that are important in the inflammatory reflex pathway. Increased sympathetic drive to the kidney has a role in the pathogenesis of hypertension, and selective modulation of neuroimmune interactions in the kidney could potentially be more effective for lowering blood pressure and treating inflammatory kidney diseases than renal denervation. Use of optogenetic tools for selective stimulation of specific neurons has enabled the identification of neural circuits in the brain that modulate kidney function via activation of the CAP. In this Review we discuss evidence for a role of neural circuits in the control of renal inflammation as well as the therapeutic potential of targeting these circuits in the settings of AKI, kidney fibrosis and hypertension.

    更新日期:2017-10-11
  • Renal physiology: ER-associated degradation in diabetes insipidus
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Susan J. Allison

    Renal physiology: ER-associated degradation in diabetes insipidus Nature Reviews Nephrology, Published online: 9 October 2017; doi:10.1038/nrneph.2017.144

    更新日期:2017-10-11
  • New treatment paradigms for ADPKD: moving towards precision medicine
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Matthew B. Lanktree, Arlene B. Chapman

    The natural history of autosomal dominant polycystic kidney disease (ADPKD) is characterized by a variable rate of cyst development and increase in total kidney volume (TKV), variable kidney function decline and age of onset of end-stage renal disease (ESRD), and variable presentation of renal and extrarenal manifestations. Precision medicine is proposed to improve patient outcomes by tailoring therapy to the specific genetic background, pathophysiology, disease burden, prognosis and status of each individual. This approach to the management of patients with ADPKD is nearing clinical implementation owing to advances in genetics, imaging, biomarker development and therapeutics. In this Review, we discuss pharmacological and non-pharmacological interventions for the treatment of hypertension and proteinuria, and for slowing the rate of cyst growth in patients with ADPKD before the development of ESRD. We provide recommendations for the management of renal complications, including cyst infection, nephrolithiasis, haematuria and chronic pain. The early treatment of patients with ADPKD who are largely asymptomatic is associated with a therapeutic burden but slows cyst growth and delays subsequent loss of kidney function, which ultimately delays the need for renal replacement therapy and has a positive effect on the quality of life of patients.

    更新日期:2017-10-11
  • Glomerular disease: Loss of Epas1 promotes FSGS
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Jack M. Heintze

    Glomerular disease: Loss of Epas1 promotes FSGS Nature Reviews Nephrology, Published online: 9 October 2017; doi:10.1038/nrneph.2017.143

    更新日期:2017-10-11
  • Diabetic nephropathy: Renoprotective effects of GLP1R agonists and SGLT2 inhibitors
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Berthold Hocher, Oleg Tsuprykov

    Diabetic nephropathy: Renoprotective effects of GLP1R agonists and SGLT2 inhibitors Nature Reviews Nephrology, Published online: 9 October 2017; doi:10.1038/nrneph.2017.140 New data from the LEADER trial show that the glucagon-like peptide 1 receptor agonist liraglutide protects against diabetic nephropathy in patients with type 2 diabetes mellitus. The renoprotective efficacy of liraglutide is not, however, as great as that reported for the sodium-glucose cotransporter 2 inhibitor emplagiflozin in the EMPA-REG OUTCOME trial.

    更新日期:2017-10-11
  • Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Andrey V. Cybulsky

    Progress has been made in our understanding of the mechanisms of endoplasmic reticulum (ER) proteostasis, ER stress and the unfolded protein response (UPR), as well as ER stress-induced autophagy, in the kidney. Experimental models have revealed that disruption of the UPR, including a protein that senses misfolded proteins (namely, inositol-requiring enzyme 1α) in mouse podocytes causes podocyte injury and albuminuria as mice age. Protein misfolding and ER stress are evident in various renal diseases, including primary glomerulonephritides, glomerulopathies associated with genetic mutations, diabetic nephropathy, acute kidney injury, chronic kidney disease and renal fibrosis. The induction of ER stress may be cytoprotective, or it may be cytotoxic by activating apoptosis. The UPR may interact in a coordinated manner with autophagy to alleviate protein misfolding and its consequences. Monitoring the excretion of ER chaperones into the urine can potentially serve as a biomarker of renal ER stress. In specific kidney diseases, the treatment of experimental animals with chemical chaperones that improve protein folding or with chaperone inducers has alleviated kidney injury. Given the limited availability of mechanism-based therapies for kidney diseases, normalization of ER stress using pharmacological agents represents a promising therapeutic approach towards preventing or arresting the progression of kidney disease.

    更新日期:2017-10-11
  • Epigenetics: Disturbed imprinting in pre-eclampsia
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ellen F. Carney

    Epigenetics: Disturbed imprinting in pre-eclampsia Nature Reviews Nephrology, Published online: 3 October 2017; doi:10.1038/nrneph.2017.141

    更新日期:2017-10-11
  • Targeting neural reflex circuits in immunity to treat kidney disease
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Mark D. Okusa, Diane L. Rosin, Kevin J. Tracey

    Neural pathways regulate immunity and inflammation via the inflammatory reflex and specific molecular targets can be modulated by stimulating neurons. Neuroimmunomodulation by nonpharmacological methods is emerging as a novel therapeutic strategy for inflammatory diseases, including kidney diseases and hypertension. Electrical stimulation of vagus neurons or treatment with pulsed ultrasound activates the cholinergic anti-inflammatory pathway (CAP) and protects mice from acute kidney injury (AKI). Direct innervation of the kidney, by afferent and efferent neurons, might have a role in modulating and responding to inflammation in various diseases, either locally or by providing feedback to regions of the central nervous system that are important in the inflammatory reflex pathway. Increased sympathetic drive to the kidney has a role in the pathogenesis of hypertension, and selective modulation of neuroimmune interactions in the kidney could potentially be more effective for lowering blood pressure and treating inflammatory kidney diseases than renal denervation. Use of optogenetic tools for selective stimulation of specific neurons has enabled the identification of neural circuits in the brain that modulate kidney function via activation of the CAP. In this Review we discuss evidence for a role of neural circuits in the control of renal inflammation as well as the therapeutic potential of targeting these circuits in the settings of AKI, kidney fibrosis and hypertension.

    更新日期:2017-10-11
  • Renal physiology: Prostaglandins in thiazide-induced hyponatraemia: do they hold water?
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ewout J. Hoorn, Jack F. M. Wetzels

    Renal physiology: Prostaglandins in thiazide-induced hyponatraemia: do they hold water? Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.133 Thiazide diuretics lower blood pressure and cardiovascular risk but can cause severe hyponatraemia. Researchers now demonstrate that thiazide-induced hyponatraemia is associated with a genetic variant in a distal nephron prostaglandin transporter. They propose that reduced prostaglandin reabsorption through this transporter facilitates activation of the prostaglandin EP4 receptor to increase water reabsorption.

    更新日期:2017-09-25
  • Gradual initiation of dialysis as a means to reduce cost while providing quality health care
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Mohamed E. Elrggal, Rowan Zyada

    Gradual initiation of dialysis as a means to reduce cost while providing quality health care Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.135

    更新日期:2017-09-25
  • Developmental biology: Single-cell RNA sequencing identifies novel kidney cell types in zebrafish
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Jack M. Heintze

    Developmental biology: Single-cell RNA sequencing identifies novel kidney cell types in zebrafish Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.137

    更新日期:2017-09-25
  • Inflammation: Activated protein C inhibits inflammasome activation in IRI
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ellen F. Carney

    Inflammation: Activated protein C inhibits inflammasome activation in IRI Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.139

    更新日期:2017-09-25
  • Continuing the paradigm shift in the treatment of idiopathic membranous nephropathy
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Antoine Barbari

    Continuing the paradigm shift in the treatment of idiopathic membranous nephropathy Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.134

    更新日期:2017-09-25
  • Further approaches to reduce the cost of renal replacement therapy
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Raymond Vanholder, Lieven Annemans, Edwina Brown, Ron Gansevoort, Judith J. Gout-Zwart, Norbert Lameire, Rachael L. Morton, Rainer Oberbauer, Maarten J. Postma, Marcello Tonelli, Wim Van Biesen, Carmine Zoccali, on behalf of the European Kidney Health Alliance

    Further approaches to reduce the cost of renal replacement therapy Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.136

    更新日期:2017-09-25
  • Renal physiology: Prostaglandins in thiazide-induced hyponatraemia: do they hold water?
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ewout J. Hoorn, Jack F. M. Wetzels

    Renal physiology: Prostaglandins in thiazide-induced hyponatraemia: do they hold water? Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.133 Thiazide diuretics lower blood pressure and cardiovascular risk but can cause severe hyponatraemia. Researchers now demonstrate that thiazide-induced hyponatraemia is associated with a genetic variant in a distal nephron prostaglandin transporter. They propose that reduced prostaglandin reabsorption through this transporter facilitates activation of the prostaglandin EP4 receptor to increase water reabsorption.

    更新日期:2017-09-25
  • Gradual initiation of dialysis as a means to reduce cost while providing quality health care
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Mohamed E. Elrggal, Rowan Zyada

    Gradual initiation of dialysis as a means to reduce cost while providing quality health care Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.135

    更新日期:2017-09-25
  • Developmental biology: Single-cell RNA sequencing identifies novel kidney cell types in zebrafish
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Jack M. Heintze

    Developmental biology: Single-cell RNA sequencing identifies novel kidney cell types in zebrafish Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.137

    更新日期:2017-09-25
  • Inflammation: Activated protein C inhibits inflammasome activation in IRI
    Nat. Rev. Nephrol. (IF 12.146) Pub Date : 
    Ellen F. Carney

    Inflammation: Activated protein C inhibits inflammasome activation in IRI Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.139

    更新日期:2017-09-25
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
化学 · 材料 期刊列表