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Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-17 Cecilia A. Hinojosa, Grace C. George, Ziv Ben-Zion
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Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-15 Yasmina Curto, Héctor Carceller, Patrycja Klimczak, Marta Perez-Rando, Qing Wang, Katharina Grewe, Riki Kawaguchi, Silvio Rizzoli, Daniel Geschwind, Klaus-Armin Nave, Vicent Teruel-Marti, Manvendra Singh, Hannelore Ehrenreich, Juan Nácher
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Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-13 Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung, Lindsay N. Hayes, Rupali Srivastava, Manling Zhang, Taro Kariya, Noah Elkins, Trexy Palen, Elisa Carloni, Tsuyoshi Tsujimura, Coleman Calva, Satoshi Ikemoto, Rana Rais, Barbara S. Slusher, Minae Niwa, Atsushi Saito, Toshiaki Saitoh, Eiki Takimoto, Akira Sawa
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Dentate gyrus is needed for memory retrieval Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-12 Alejandro Carretero-Guillén, Mario Treviño, María Ángeles Gómez-Climent, Godwin K. Dogbevia, Ilaria Bertocchi, Rolf Sprengel, Matthew E. Larkum, Andreas Vlachos, Agnès Gruart, José M. Delgado-García, Mazahir T. Hasan
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Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-12 Kaustubh Supekar, Carlo de los Angeles, Srikanth Ryali, Leila Kushan, Charlie Schleifer, Gabriela Repetto, Nicolas A. Crossley, Tony Simon, Carrie E. Bearden, Vinod Menon
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Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-11 Jana F. Totzek, M. Mallar Chakravarty, Ridha Joober, Ashok Malla, Jai L. Shah, Delphine Raucher-Chéné, Alexandra L. Young, Dennis Hernaus, Martin Lepage, Katie M. Lavigne
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Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-10 Yangjun Liu, Paul Lichtenstein, Roman Kotov, Henrik Larsson, Brian M. D’Onofrio, Erik Pettersson
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Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-08 Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Yiyun Huang, Yang Yang, Zengping Lin, Tengfei Guo, Jun Zhao, Yihui Guan, Binyin Li, Fang Xie
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Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-05 Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Hang Zhou, Murray B. Stein, Joel Gelernter
Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using cannabis develop CanUD, and the number of users has grown with increasing ease of access. CanUD and other substance use disorders (SUDs) are associated phenotypically and genetically. We leveraged new CanUD genomics data to undertake genetically-informed analyses with unprecedented
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Social experience in adolescence shapes prefrontal cortex structure and function in adulthood Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-05 Dan C. Li, Elizabeth A. Hinton, Jidong Guo, Kristopher A. Knight, Michelle K. Sequeira, Meghan E. Wynne, Niharika M. Dighe, Shannon L. Gourley
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC development is profoundly influenced by the social environment, disruptions to which may prime the emergence of psychopathology across the lifespan. We investigated the neurobehavioral consequences of isolation experienced in adolescence in mice, and in particular, the long-term consequences that were detectable
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Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Arnau Ramos-Prats, Pawel Matulewicz, Marie-Luise Edenhofer, Kai-Yi Wang, Chia-Wei Yeh, Ana Fajardo-Serrano, Michaela Kress, Kai Kummer, Cheng-Chang Lien, Francesco Ferraguti
Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu5 act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu5 has been proposed to contribute to the exacerbation of neuropsychiatric disorders
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Substance use and spine density: a systematic review and meta-analysis of preclinical studies Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02 Henrique Nunes Pereira Oliva, Tiago Paiva Prudente, Eric J. Nunes, Kelly P. Cosgrove, Rajiv Radhakrishnan, Marc N. Potenza, Gustavo A. Angarita
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies, synaptic density markers, like spine density, are altered by substances of abuse (e.g., alcohol, amphetamine, cannabis, cocaine, opioids, nicotine). These changes could be linked to phenomena including behavioral sensitization and drug self-administration
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Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Jacob J. Crouse, Shin Ho Park, Enda M. Byrne, Brittany L. Mitchell, Jan Scott, Sarah E. Medland, Tian Lin, Naomi R. Wray, Nicholas G. Martin, Ian B. Hickie
The dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year
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Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects? Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Brandi Quintanilla, Carlos A. Zarate, Anilkumar Pillai
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30–40% of patients with MDD achieve complete remission after conventional monoamine antidepressant therapy. In recent years, ketamine has revolutionized the treatment of MDD, with its rapid antidepressant effects manifesting within a few hours as opposed to weeks with conventional antidepressants. Many
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Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02 Supriya A. Gaitonde, Charlotte Avet, Mario de la Fuente Revenga, Elodie Blondel-Tepaz, Aida Shahraki, Adrian Morales Pastor, Valerij Talagayev, Patricia Robledo, Peter Kolb, Jana Selent, Javier González-Maeso, Michel Bouvier
The intricate involvement of the serotonin 5-HT2A receptor (5-HT2AR) both in schizophrenia and in the activity of antipsychotic drugs is widely acknowledged. The currently marketed antipsychotic drugs, although effective in managing the symptoms of schizophrenia to a certain extent, are not without their repertoire of serious side effects. There is a need for better therapeutics to treat schizophrenia
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Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02
Epigenetic age acceleration (EAA), defined as the difference between chronological age and epigenetically predicted age, was calculated from multiple gestational epigenetic clocks (Bohlin, EPIC overlap, and Knight) using DNA methylation levels from cord blood in three large population-based birth cohorts: the Generation R Study (The Netherlands), the Avon Longitudinal Study of Parents and Children
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Differential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02 Juliette Salles, Sanaa Eddiry, Saber Amri, Mélissa Galindo, Emmanuelle Lacassagne, Simon George, Xavier Mialhe, Émeline Lhuillier, Nicolas Franchitto, Freddy Jeanneteau, Isabelle Gennero, Jean-Pierre Salles, Maithé Tauber
Introduction A microdeletion including the SNORD116 gene (SNORD116 MD) has been shown to drive the Prader-Willi syndrome (PWS) features. PWS is a neurodevelopmental disorder clinically characterized by endocrine impairment, intellectual disability and psychiatric symptoms such as a lack of emotional regulation, impulsivity, and intense temper tantrums with outbursts. In addition, this syndrome is associated
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Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-01 Anders Kämpe, Jaana Suvisaari, Markku Lähteenvuo, Tarjinder Singh, Ari Ahola-Olli, Lea Urpa, Willehard Haaki, Jarmo Hietala, Erkki Isometsä, Tuomas Jukuri, Olli Kampman, Tuula Kieseppä, Kaisla Lahdensuo, Jouko Lönnqvist, Teemu Männynsalo, Tiina Paunio, Jussi Niemi-Pynttäri, Kimmo Suokas, Annamari Tuulio-Henriksson, Juha Veijola, Asko Wegelius, Mark Daly, Jacob Taylor, Kenneth S. Kendler, Aarno Palotie
Genetic factors contribute to the susceptibility of psychotic disorders, but less is known how they affect psychotic disease-course development. Utilizing polygenic scores (PGSs) in combination with longitudinal healthcare data with decades of follow-up we investigated the contributing genetics to psychotic disease-course severity and diagnostic shifts in the SUPER-Finland study, encompassing 10 403
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Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-29 Eugenia Vivi, Barbara Di Benedetto
In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and membrane-bound proteins. An imbalanced astrocyte activity can therefore have drastic negative impacts on brain development, leading to the onset of severe pathologies. Clinical and pre-clinical studies show alterations in astrocyte cell number, morphology, molecular
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Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-29 Florian Thomas-Odenthal, Kai Ringwald, Lea Teutenberg, Frederike Stein, Nina Alexander, Linda M. Bonnekoh, Katharina Brosch, Katharina Dohm, Kira Flinkenflügel, Dominik Grotegerd, Tim Hahn, Andreas Jansen, Elisabeth J. Leehr, Susanne Meinert, Julia-Katharina Pfarr, Harald Renz, Navid Schürmeyer, Thomas Stief, Benjamin Straube, Katharina Thiel, Paula Usemann, Alexandra Winter, Axel Krug, Igor Nenadić
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The relationship between prefrontal cortex gray matter volume and subcortical dopamine release - an addendum Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-28 Matthäus Willeit, Ulrich Sauerzopf, Nicole Praschak-Rieder, Ana Weidenauer
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Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-28 Jorge A. Sanchez-Ruiz, Brandon J. Coombes, Vanessa M. Pazdernik, Lindsay M. Melhuish Beaupre, Greg D. Jenkins, Richard S. Pendegraft, Anthony Batzler, Aysegul Ozerdem, Susan L. McElroy, Manuel A. Gardea-Resendez, Alfredo B. Cuellar-Barboza, Miguel L. Prieto, Mark A. Frye, Joanna M. Biernacka
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Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-28 Nora I. Strom, Christie L. Burton, Conrad Iyegbe, Talisa Silzer, Lilit Antonyan, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell Schachar, Hei Man Wu, Danielle Cath, Jennifer Crosbie, David Mataix-Cols, Dorret I. Boomsma, Manuel Mattheisen, Sandra M. Meier, Dirk J. A. Smit, Paul D. Arnold
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Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Iseline Cardon, Sonja Grobecker, Frederike Jenne, Tatjana Jahner, Rainer Rupprecht, Vladimir M. Milenkovic, Christian H. Wetzel
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Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Federica Geraci, Roberta Passiatore, Nora Penzel, Samuele Laudani, Alessandro Bertolino, Giuseppe Blasi, Adriana C. E. Graziano, Gianluca C. Kikidis, Ciro Mazza, Madhur Parihar, Antonio Rampino, Leonardo Sportelli, Nicolò Trevisan, Filippo Drago, Francesco Papaleo, Fabio Sambataro, Giulio Pergola, Gian Marco Leggio
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Immunophenotypes in psychosis: is it a premature inflamm-aging disorder? Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Song Chen, Yunlong Tan, Li Tian
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Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Sarah Grosshagauer, Michael Woletz, Maria Vasileiadi, David Linhardt, Lena Nohava, Anna-Lisa Schuler, Christian Windischberger, Nolan Williams, Martin Tik
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Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Takumi Nakamura, Toru Yoshihara, Chiharu Tanegashima, Mitsutaka Kadota, Yuki Kobayashi, Kurara Honda, Mizuho Ishiwata, Junko Ueda, Tomonori Hara, Moe Nakanishi, Toru Takumi, Shigeyoshi Itohara, Shigehiro Kuraku, Masahide Asano, Takaoki Kasahara, Kazuo Nakajima, Takashi Tsuboi, Atsushi Takata, Tadafumi Kato
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Active forgetting and neuropsychiatric diseases Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-26 Jacob A. Berry, Dana C. Guhle, Ronald L. Davis
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Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-25 Sanne Y. Smith-Apeldoorn, Jolien K. E. Veraart, Jeanine Kamphuis, Jan Spijker, Annemarie van der Meij, Antoinette D. I. van Asselt, Marije aan het Rot, Robert A. Schoevers
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Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-25 Monica Margoni, Paola Valsasina, Anna Bacchetti, Damiano Mistri, Paolo Preziosa, Maria A. Rocca, Massimo Filippi
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The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-22 Orthis Saha, Ana Raquel Melo de Farias, Alexandre Pelletier, Dolores Siedlecki-Wullich, Bruna Soares Landeira, Johanna Gadaut, Arnaud Carrier, Anaïs-Camille Vreulx, Karine Guyot, Yun Shen, Amelie Bonnefond, Philippe Amouyel, Julia TCW, Devrim Kilinc, Claudio Marcos Queiroz, Fabien Delahaye, Jean-Charles Lambert, Marcos R. Costa
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Genetic contribution to microglial activation in schizophrenia Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-22 Marja Koskuvi, Elina Pörsti, Tristen Hewitt, Noora Räsänen, Ying-Chieh Wu, Kalevi Trontti, Amanda McQuade, Shringaa Kalyanaraman, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, Taisia Rolova, Šárka Lehtonen, Jari Tiihonen, Jari Koistinaho
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The nested hierarchical model of self and its non-relational vs relational posttraumatic manifestation: an fMRI meta-analysis of emotional processing Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-21 Andrea Scalabrini, Marco Cavicchioli, Francesco Benedetti, Clara Mucci, Georg Northoff
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Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-21 Bryan Cruz, Valentina Vozella, Vittoria Borgonetti, Ryan Bullard, Paula C. Bianchi, Dean Kirson, Luisa B. Bertotto, Michal Bajo, Roman Vlkolinsky, Robert O. Messing, Eric P. Zorrilla, Marisa Roberto
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Discontinuation of psychotropic medication: a synthesis of evidence across medication classes Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Christiaan H. Vinkers, Ralph W. Kupka, Brenda W. Penninx, Henricus G. Ruhé, Jakob M. van Gaalen, Paul C. F. van Haaren, Arnt F. A. Schellekens, Sameer Jauhar, Josep A. Ramos-Quiroga, Eduard Vieta, Jari Tiihonen, Stijn E. Veldman, Wim Veling, Roeland Vis, Laura E. de Wit, Jurjen J. Luykx
Pharmacotherapy is an effective treatment modality across psychiatric disorders. Nevertheless, many patients discontinue their medication at some point. Evidence-based guidance for patients, clinicians, and policymakers on rational discontinuation strategies is vital to enable the best, personalized treatment for any given patient. Nonetheless, there is a scarcity of guidelines on discontinuation strategies
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Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Yong-Xia Li, Zhi-Nei Tan, Xu-Hui Li, Boyu Ma, Frank Adu Nti, Xiao-Qiang Lv, Zhen-Jun Tian, Riqiang Yan, Heng-Ye Man, Xin-Ming Ma
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Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Beatriz Garcia-Ruiz, Esther Jiménez, Selena Aranda, Norma Verdolini, Alfonso Gutiérrez-Zotes, Cristina Sáez, Elisa Losantos, Silvia Alonso-Lana, Mar Fatjó-Vilas, Salvador Sarró, Llanos Torres, Francesco Panicalli, Caterina del Mar Bonnin, Edith Pomarol-Clotet, Eduard Vieta, Elisabet Vilella
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The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Zoe S. J. Liu, Trang T. T. Truong, Chiara C. Bortolasci, Briana Spolding, Bruna Panizzutti, Courtney Swinton, Jee Hyun Kim, Damián Hernández, Srisaiyini Kidnapillai, Laura Gray, Michael Berk, Olivia M. Dean, Ken Walder
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Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Markos Tesfaye, Leticia M. Spindola, Anne-Kristin Stavrum, Alexey Shadrin, Ingrid Melle, Ole A. Andreassen, Stephanie Le Hellard
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Effect of olanzapine exposure on relapse and brain structure in patients with major depressive disorder with psychotic features Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Helena K. Kim, Aristotle N. Voineskos, Nicholas H. Neufeld, George S. Alexopoulos, Kathleen S. Bingham, Alastair J. Flint, Patricia Marino, Anthony J. Rothschild, Ellen M. Whyte, Benoit H. Mulsant
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Data-driven, connectome-wide analysis identifies psychosis-specific brain correlates of fear and anxiety Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Brandee Feola, Adam Beermann, Karlos Manzanarez Felix, Michael Coleman, Sylvain Bouix, Daphne J. Holt, Kathryn E. Lewandowski, Dost Öngür, Alan Breier, Martha E. Shenton, Stephan Heckers, Roscoe O. Brady, Jennifer Urbano Blackford, Heather Burrell Ward
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Gephyrin phosphorylation facilitates sexually dimorphic development and function of parvalbumin interneurons in the mouse hippocampus Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Benjamin F. N. Campbell, Natalia Cruz-Ochoa, Kanako Otomo, David Lukacsovich, Pedro Espinosa, Andrin Abegg, Wenshu Luo, Camilla Bellone, Csaba Földy, Shiva K. Tyagarajan
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Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-19 Francesco Bavato, Christian Barro, Laura K. Schnider, Joel Simrén, Henrik Zetterberg, Erich Seifritz, Boris B. Quednow
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Are microglia in charge of controlling stress-response behavior? Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18
Chronic anxiety is a widespread mental health challenge that affects a considerable population worldwide [1]. From 2008 to 2018, anxiety significantly risen in the United States, especially in young adults aged 18–25. This particular age group has experienced the most significant increase, which was faster than other age groups [1]. Anxiety significantly impacts patients’ daily functioning, psychological
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Genetics of environmental sensitivity and its association with variations in emotional problems, autistic traits, and wellbeing Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Elham Assary, Olakunle A. Oginni, Genevieve Morneau-Vaillancourt, Georgina Krebs, Alicia J. Peel, Elisavet Palaiologou, Celestine Lockhart, Angelica Ronald, Thalia C. Eley
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Genetic overlap between Alzheimer’s disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Nitesh Enduru, Brisa S. Fernandes, Shahram Bahrami, Yulin Dai, Ole A. Andreassen, Zhongming Zhao
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Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen, Kyle Wettschurack, Zhefu Que, Brody A. Deming, Maria I. Olivero-Acosta, Ningren Cui, Muriel Eaton, Yuanrui Zhao, Sophia M. Li, Matthew Suzuki, Ian Chen, Tiange Xiao, Manasi S. Halurkar, Purba Mandal, Chongli Yuan, Ranjie Xu, Wendy A. Koss, Dongshu Du, Fuxue Chen, Long-jun Wu, Yang Yang
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The impact of adult neurogenesis on affective functions: of mice and men Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Mariana Alonso, Anne-Cécile Petit, Pierre-Marie Lledo
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Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Gerhard Leinenga, Xuan Vinh To, Liviu-Gabriel Bodea, Jumana Yousef, Gina Richter-Stretton, Tishila Palliyaguru, Antony Chicoteau, Laura Dagley, Fatima Nasrallah, Jürgen Götz
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Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-15 Tracy L. Warren, Justin D. Tubbs, Tyler A. Lesh, Mylena B. Corona, Sarvenaz S. Pakzad, Marina D. Albuquerque, Praveena Singh, Vanessa Zarubin, Sarah J. Morse, Pak Chung Sham, Cameron S. Carter, Alex S. Nord
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Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-15 Tim B. Bigdeli, Peter B. Barr, Nallakkandi Rajeevan, David P. Graham, Yuli Li, Jacquelyn L. Meyers, Bryan R. Gorman, Roseann E. Peterson, Frederick Sayward, Krishnan Radhakrishnan, Sundar Natarajan, David A. Nielsen, Anna V. Wilkinson, Anil K. Malhotra, Hongyu Zhao, Mary Brophy, Yunling Shi, Timothy J. O’Leary, Theresa Gleason, Ronald Przygodzki, Saiju Pyarajan, Sumitra Muralidhar, J. Michael Gaziano
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Developing an individualized treatment rule for Veterans with major depressive disorder using electronic health records Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Nur Hani Zainal, Robert M. Bossarte, Sarah M. Gildea, Irving Hwang, Chris J. Kennedy, Howard Liu, Alex Luedtke, Brian P. Marx, Maria V. Petukhova, Edward P. Post, Eric L. Ross, Nancy A. Sampson, Erik Sverdrup, Brett Turner, Stefan Wager, Ronald C. Kessler
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Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 William Wang, Nora D. Volkow, Nathan A. Berger, Pamela B. Davis, David C. Kaelber, Rong Xu
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Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Edênia C. Menezes, Heather Geiger, Fabiula F. Abreu, Lital Rachmany, Donald A. Wilson, Melissa J. Alldred, Francisco X. Castellanos, Rui Fu, Derya Sargin, André Corvelo, Cátia M. Teixeira
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Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Pol Puigseslloses, Núria Nadal-Gratacós, Gabriel Ketsela, Nicola Weiss, Xavier Berzosa, Roger Estrada-Tejedor, Mohammad Nazmul Islam, Marion Holy, Marco Niello, David Pubill, Jordi Camarasa, Elena Escubedo, Harald H. Sitte, Raúl López-Arnau
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Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iPSNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Yi-Zhi Wang, Tamara Perez-Rosello, Samuel N. Smukowski, D. James Surmeier, Jeffrey N. Savas
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Painful physical symptoms and antidepressant treatment outcome in depression: a systematic review and meta-analysis Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-13 Jia Jia Liu, Xiao Huang, Yan-Ping Bao, Lin Lu, Ping Dong, Owen M. Wolkowitz, John R. Kelsoe, Jie Shi, Ya Bin Wei
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Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-08 Shen Lin, Cui-ying Fan, Hao-ran Wang, Xiao-fan Li, Jia-li Zeng, Pei-xuan Lan, Hui-xian Li, Bin Zhang, Chun Hu, Junyu Xu, Jian-hong Luo
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Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-08 Ethan J. Goodman, Rebecca G. Biltz, Jonathan M. Packer, Damon J. DiSabato, Samuel P. Swanson, Braeden Oliver, Ning Quan, John F. Sheridan, Jonathan P. Godbout