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  • Ethnicity and maternal and child health outcomes and service coverage in western China: a systematic review and meta-analysis
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-16
    Yuan Huang, David Shallcross, Li Pi, Fan Tian, Jay Pan, Carine Ronsmans
    更新日期:2017-11-17
  • Ethnicity and MCH outcomes: widening gaps across time and space
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-16
    Lei Wang, Scott Rozelle

    The systematic review that is published in The Lancet Global Health by the collaborative team1 from the London School of Hygiene & Tropical Medicine (LSHTM) and Sichuan University is critical to our understanding of human capital gaps between ethnic minorities and Han individuals (China's ethnic majority). Regardless of the maternal and child health (MCH) outcome, women and their children from ethnic minority groups in China perform far worse than their Han counterparts. If anything, the authors underplay the inequalities in at least three ways.

    更新日期:2017-11-17
  • Tuberculosis makes it onto the international political agenda for health…finally
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-15
    Mario Raviglione, Mukund Uplekar, Diana Weil, Teresa Kasaeva

    The fact that more than 10 million people fall ill with tuberculosis annually, and that 5000 die of it every day, including about 1000 because of HIV-associated infection, speaks to the gravity of the global problem of tuberculosis. Tuberculosis has many other dubious distinctions that merit attention: it is one of the oldest diseases known to mankind and yet one of the top ten global causes of death today, the top infectious cause of death worldwide, the top killer of people with HIV infection, and a top cause of death due to antimicrobial-resistant infections.

    更新日期:2017-11-16
  • Prevalence of cerebral palsy in Uganda: a population-based study
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Angelina Kakooza-Mwesige, Carin Andrews, Stefan Peterson, Fred Wabwire Mangen, Ann Christin Eliasson, Hans Forssberg
    更新日期:2017-11-11
  • Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-26
    Oriol Mitjà, Camila González-Beiras, Charmie Godornes, Reman Kolmau, Wendy Houinei, Haina Abel, August Kapa, Raymond Paru, Sibauk V Bieb, James Wangi, Sergi Sanz, Kingsley Asiedu, Sheila A Lukehart, Quique Bassat
    更新日期:2017-11-11
  • Effect of a training and educational intervention for physicians and caregivers on antibiotic prescribing for upper respiratory tract infections in children at primary care facilities in rural China: a cluster-randomised controlled trial
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Xiaolin Wei, Zhitong Zhang, John D Walley, Joseph P Hicks, Jun Zeng, Simin Deng, Yu Zhou, Jia Yin, James N Newell, Qiang Sun, Guanyang Zou, Yan Guo, Ross E G Upshur, Mei Lin
    更新日期:2017-11-11
  • 更新日期:2017-11-11
  • Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-11
    Seth R Flaxman, Rupert R A Bourne, Serge Resnikoff, Peter Ackland, Tasanee Braithwaite, Maria V Cicinelli, Aditi Das, Jost B Jonas, Jill Keeffe, John H Kempen, Janet Leasher, Hans Limburg, Kovin Naidoo, Konrad Pesudovs, Alex Silvester, Gretchen A Stevens, Nina Tahhan, Tien Y Wong, Hugh R Taylor, Rupert Bourne, Peter Ackland, Aries Arditi, Yaniv Barkana, Banu Bozkurt, Tasanee Braithwaite, Alain Bron, Donald Budenz, Feng Cai, Robert Casson, Usha Chakravarthy, Jaewan Choi, Maria Vittoria Cicinelli, Nathan Congdon, Reza Dana, Rakhi Dandona, Lalit Dandona, Aditi Das, Iva Dekaris, Monte Del Monte, Jenny deva, Laura Dreer, Leon Ellwein, Marcela Frazier, Kevin Frick, David Friedman, Joao Furtado, Hua Gao, Gus Gazzard, Ronnie George, Stephen Gichuhi, Victor Gonzalez, Billy Hammond, Mary Elizabeth Hartnett, Minguang He, James Hejtmancik, Flavio Hirai, John Huang, April Ingram, Jonathan Javitt, Jost Jonas, Charlotte Joslin, Jill Keeffe, John Kempen, Moncef Khairallah, Rohit Khanna, Judy Kim, George Lambrou, Van Charles Lansingh, Paolo Lanzetta, Janet Leasher, Jennifer Lim, Hans LIMBURG, Kaweh Mansouri, Anu Mathew, Alan Morse, Beatriz Munoz, David Musch, Kovin Naidoo, Vinay Nangia, Maria Palaiou, Maurizio Battaglia Parodi, Fernando Yaacov Pena, Konrad Pesudovs, Tunde Peto, Harry Quigley, Murugesan Raju, Pradeep Ramulu, Zane Rankin, Serge Resnikoff, Dana Reza, Alan Robin, Luca Rossetti, Jinan Saaddine, Mya Sandar, Janet Serle, Tueng Shen, Rajesh Shetty, Pamela Sieving, Juan Carlos Silva, Alex Silvester, Rita S. Sitorus, Dwight Stambolian, Gretchen Stevens, Hugh Taylor, Jaime Tejedor, James Tielsch, Miltiadis Tsilimbaris, Jan van Meurs, Rohit Varma, Gianni Virgili, Ya Xing Wang, Ning-Li Wang, Sheila West, Peter Wiedemann, Tien Wong, Richard Wormald, Yingfeng Zheng
    更新日期:2017-11-11
  • Global, regional, and country-level coverage of interventions to prevent and manage HIV and hepatitis C among people who inject drugs: a systematic review
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-23
    Sarah Larney, Amy Peacock, Janni Leung, Samantha Colledge, Matthew Hickman, Peter Vickerman, Jason Grebely, Kostyantyn V Dumchev, Paul Griffiths, Lindsey Hines, Evan B Cunningham, Richard P Mattick, Michael Lynskey, John Marsden, John Strang, Louisa Degenhardt
    更新日期:2017-11-11
  • Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic review
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-23
    Louisa Degenhardt, Amy Peacock, Samantha Colledge, Janni Leung, Jason Grebely, Peter Vickerman, Jack Stone, Evan B Cunningham, Adam Trickey, Kostyantyn Dumchev, Michael Lynskey, Paul Griffiths, Richard P Mattick, Matthew Hickman, Sarah Larney
    更新日期:2017-11-11
  • Severe malnutrition in infants displaced from Mosul, Iraq
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Mohamad K Haidar, Jihane Ben Farhat, Malika Saim, Nikola Morton, Isabelle Defourny

    Médecins Sans Frontières (MSF) provides emergency medical care, including mother and child care, in 10 governorates of Iraq. The military operation by the Iraqi government on Mosul, the second largest city in Iraq, began in late 2016 and ended with a siege of the city that lasted from February, 2017 until July, 2017. The siege led to food shortages, and subsequent mass displacements presented further challenges for food security.

    更新日期:2017-11-11
  • Developing an antimicrobial resistance reference laboratory and surveillance programme in Vietnam
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Nguyen Van Kinh, Heiman F L Wertheim, Guy E Thwaite, Luong Ngoc Khue, Cao Hung Thai, Nguyen Trong Khoa, Ngo thi Bich Ha, Nguyen Vu Trung, Derrick Crook, H Rogier van Doorn

    The Fleming Fund was established by the UK Government in 2015 in response to recommendations of an independent review on antimicrobial resistance (AMR) led by economist Jim O'Neill and the Global Action Plan on AMR adopted by the World Health Assembly in 2015.1 These recommendations were subsequently endorsed by the General Assembly of the Food and Agriculture Organisation (FAO) and World Organisation for Animal Health (OIE).

    更新日期:2017-11-11
  • Gender myths in global health—a response to the response
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Deborah Ottenheimer

    The promotion of women leaders in global health as outlined by Talib and colleagues1 is a commendable and important goal. My hope has always been that gender parity in this field will lead to a greater recognition of the enormous health burdens suffered by women in both the global North and South. With this in mind, it was with dismay that I read the letter Gender myths in global health2 and the authors' response (September issue).3

    更新日期:2017-11-11
  • The costs of reaching the health-related SDGs
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Kunhee Park, Katherine Gilbert, Peter L Annear

    Karin Stenberg and colleagues1 estimate the resources needed at both country and global levels to progress towards the health-related Sustainable Development Goals (SDGs). Their analysis included 67 low-income and middle-income countries, selected on the basis of income and population, which account for 95% of the population in all low-income and middle-income countries.

    更新日期:2017-11-11
  • The costs of reaching the health-related SDGs
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Arian Hatefi

    The estimated additional US$274–$371 billion needed annually until 2030 to achieve the targets of Sustainable Development Goal 3 (SDG3) in low-income and middle-income countries (September issue, p e875)1 may seem like a high price tag—it is. But these costs account almost exclusively for downstream health-system investments. The donor community can perhaps help relieve this cost burden through concurrent investments in comparatively smaller, upstream, and targeted global functions.

    更新日期:2017-11-11
  • Maternal mortality: direct or indirect has become irrelevant
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Thomas van den Akker, Manisha Nair, Martijn Goedhart, Joke Schutte, Timme Schaap, Marian Knight

    Application of the tenth revision of the International Classification of Diseases (ICD) to deaths during pregnancy, childbirth, and the puerperium (ICD-Maternal Mortality [MM]) divides maternal deaths into direct obstetric deaths (ie, deaths resulting from the obstetric complications of pregnancy, interventions, omissions, incorrect treatment, or a chain of events resulting from any of the above) and indirect obstetric deaths (ie, deaths resulting from a previous existing disease, or disease that developed during pregnancy that was not due to direct obstetric causes, but was aggravated by physiological effects of pregnancy).

    更新日期:2017-11-11
  • Global infection prevention and control priorities 2018–22: a call for action
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Benedetta Allegranzi, Claire Kilpatrick, Julie Storr, Edward Kelley, Benjamin J Park, Liam Donaldson

    The Ebola virus disease outbreak in west Africa and the rapid spread of other emerging viruses, such as the severe acute respiratory syndrome or the Middle East respiratory syndrome coronaviruses, showed how limited or non-existent infection prevention and control (IPC) programmes, combined with an inadequate water supply, poor sanitation, and a weak hygiene infrastructure in health facilities, can threaten global health security. In such outbreaks, instead of serving as points where disease was controlled, health-care facilities became dangerous places for outbreak amplification among staff and patients and transmission back to communities.

    更新日期:2017-11-11
  • Vaccination to reduce antimicrobial resistance
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-08
    Amy Sarah Ginsburg, Keith P Klugman

    Pneumonia remains the leading infectious cause of death in children worldwide, and how best to reduce this burden is worth consideration on World Pneumonia Day on November 12. Antibiotics are effective in treating bacterial pneumonia and access to appropriate antibiotics can be lifesaving. Universal provision of antibiotics to children younger than 5 years could prevent an estimated mean of 445 000 deaths per year due to community-acquired pneumonia—a 75·4% reduction across 101 countries.1 Antibiotics need to be available and accessible to effectively treat pneumonia; however, inappropriate use of antibiotics can lead to the emergence and progression of antibiotic resistance, a serious public health threat.

    更新日期:2017-11-11
  • Making sense of cerebral palsy prevalence in low-income countries
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Bernard Dan, Nigel Paneth

    Much of what we know about cerebral palsy—including its effect on motor functioning, quality of life, families, and society; the importance of associated disabilities; the effectiveness of management strategies; and even fundamental epidemiological features, such as prevalence and risk factors—is derived from observations made in high-income countries (HICs). Yet, the burden of cerebral palsy is thought by many to be greater in low-income countries (LICs), for which little information is available.

    更新日期:2017-11-11
  • Single-dose azithromycin to treat latent yaws
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-26
    Michael Marks, David Mabey

    Yaws, caused by Treponema pallidum subsp pertenue, was the first disease to be targeted for eradication by WHO.1 As with other treponemal infections, such as syphilis, some people develop latent infection. These individuals have positive serological test results for yaws but no clinical signs of disease. Importantly, latent yaws can relapse, which most frequently occurs in the first 5 years after infection,2 and, therefore, these people represent an important source of reinfection in endemic communities.

    更新日期:2017-11-11
  • Reducing antibiotic prescriptions for childhood upper respiratory tract infections
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Gary W K Wong

    Resistance to antibiotics has become a major health threat worldwide, and one of the most important contributing factors is the widespread overuse of antimicrobials. This problem is most severe in low-income and middle-income countries (LMICs), where physicians have few resources for investigations and diagnosis, along with inherent concerns about missing an underlying bacterial infection. A young child usually develops between four and six episodes of upper respiratory tract infection per year.

    更新日期:2017-11-11
  • Population-level linear growth faltering in low-income and middle-income countries
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Jean H Humphrey, Andrew J Prendergast
    更新日期:2017-11-11
  • Global causes of vision loss in 2015: are we on track to achieve the Vision 2020 target?
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-11
    Charumathi Sabanayagam, Ching-Yu Cheng

    Vision impairment, including blindness, is a major public health concern in middle-aged and elderly adults worldwide, associated with diminished quality of life and increased risk of falls and death.1,2 Estimates suggest that 36 million people were blind and 217 million people had moderate or severe vision impairment worldwide in 2015.3 The Global Action Plan for 2014–19 adopted by WHO member states sets a global target of a 25% reduction in the prevalence of avoidable vision loss due to cataract and uncorrected refractive error by 2019 from the 2010 baseline level.

    更新日期:2017-11-11
  • Estimates are not enough: scaling-up interventions to improve the health of people who inject drugs
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    Maria Prins, Julie Bruneau

    At the UN General Assembly Special Session on the world drug problem (UNGASS) in New York, in April, 2016, member states reaffirmed their commitment to effectively addressing and countering the world drug problem. They also reiterated their commitment to ending the HIV and tuberculosis epidemics by 2030 and to combating viral hepatitis and other communicable diseases, among other things, in people who inject drugs (PWID).1

    更新日期:2017-11-11
  • Fighting antimicrobial resistance on all fronts
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-12-01
    The Lancet Global Health

    The theme of this year's World Antibiotic Awareness Week (Nov 13-19) is “seek advice”. But what if your health professional's advice is not evidence-based? A trial in this month's issue aimed to reduce the shockingly high antibiotic prescribing rate among doctors providing outpatient care in China. In this setting in the rural west of the country, a staggering 80% of children aged between 2 and 14 years who are diagnosed with an upper respiratory tract infection (RTI) in an outpatient clinic receive a prescription for antibiotics.

    更新日期:2017-11-11
  • Fistula recurrence, pregnancy, and childbirth following successful closure of female genital fistula in Guinea: a longitudinal study
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-09-20
    Alexandre Delamou, Therese Delvaux, Alison M El Ayadi, Vandana Tripathi, Bienvenu S Camara, Abdoul H Beavogui, Lauri Romanzi, Bethany Cole, Patrice Bouedouno, Moustapha Diallo, Thierno H Barry, Mandian Camara, Kindy Diallo, Alain Leveque, Wei-Hong Zhang, Vincent De Brouwere
    更新日期:2017-11-10
  • Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-09-27
    Ranjeeta Thomas, Ronelle Burger, Abigail Harper, Sarah Kanema, Lawrence Mwenge, Nosivuyile Vanqa, Nomtha Bell-Mandla, Peter C Smith, Sian Floyd, Peter Bock, Helen Ayles, Nulda Beyers, Deborah Donnell, Sarah Fidler, Richard Hayes, Katharina Hauck, James Hargreaves, Deborah Watson-Jones, Peter Godfrey-Faussett, Anne Cori, Mike Pickles, Nomtha Mandla, Blia Yang, Anelet James, Redwaan Vermaak, Nozizwe Makola, Graeme Hoddinott, Vikesh Naidoo, Virginia Bond, Musonda Simwinga, Alwyn Mwinga, Barry Kosloff, Mohammed Limbada, Justin Bwalya, Chepela Ngulube, Christophe Fraser, Susan Eshleman, Yaw Agyei, Vanessa Cummings, Denni Catalano, Lynda Emel, Lisa Bunts, Heather Noble, David Burns, Alain Kouda, Niru Sista, Ayana Moore, Rhonda White, Tanette Headen, Eric Miller, Kathy Hinson, Sten Vermund, Mark Barnes, Lyn Horn, Albert Mwango, Megan Baldwin, Shauna Wolf, Erin Hughes

    BackgroundThe life expectancy of HIV-positive individuals receiving antiretroviral therapy (ART) is approaching that of HIV-negative people. However, little is known about how these populations compare in terms of health-related quality of life (HRQoL). We aimed to compare HRQoL between HIV-positive and HIV-negative people in Zambia and South Africa. MethodsAs part of the HPTN 071 (PopART) study, data from adults aged 18–44 years were gathered between Nov 28, 2013, and March 31, 2015, in large cross-sectional surveys of random samples of the general population in 21 communities in Zambia and South Africa. HRQoL data were collected with a standardised generic measure of health across five domains. We used β-distributed multivariable models to analyse differences in HRQoL scores between HIV-negative and HIV-positive individuals who were unaware of their status; aware, but not in HIV care; in HIV care, but who had not initiated ART; on ART for less than 5 years; and on ART for 5 years or more. We included controls for sociodemographic variables, herpes simplex virus type-2 status, and recreational drug use. FindingsWe obtained data for 19 750 respondents in Zambia and 18 941 respondents in South Africa. Laboratory-confirmed HIV status was available for 19 330 respondents in Zambia and 18 004 respondents in South Africa; 4128 (21%) of these 19 330 respondents in Zambia and 4012 (22%) of 18 004 respondents in South Africa had laboratory-confirmed HIV. We obtained complete HRQoL information for 19 637 respondents in Zambia and 18 429 respondents in South Africa. HRQoL scores did not differ significantly between individuals who had initiated ART more than 5 years previously and HIV-negative individuals, neither in Zambia (change in mean score −0·002, 95% CI −0·01 to 0·001; p=0·219) nor in South Africa (0·000, −0·002 to 0·003; p=0·939). However, scores did differ between HIV-positive individuals who had initiated ART less than 5 years previously and HIV-negative individuals in Zambia (−0·006, 95% CI −0·008 to −0·003; p<0·0001). A large proportion of people with clinically confirmed HIV were unaware of being HIV-positive (1768 [43%] of 4128 people in Zambia and 2026 [50%] of 4012 people in South Africa) and reported good HRQoL, with no significant differences from that of HIV-negative people (change in mean HRQoL score −0·001, 95% CI −0·003 to 0·001, p=0·216; and 0·001, −0·001 to 0·001, p=0·997, respectively). In South Africa, HRQoL scores were lower in HIV-positive individuals who were aware of their status but not enrolled in HIV care (change in mean HRQoL −0·004, 95% CI −0·01 to −0·001; p=0·010) and those in HIV care but not on ART (−0·008, −0·01 to −0·004; p=0·001) than in HIV-negative people, but the magnitudes of difference were small. InterpretationART is successful in helping to reduce inequalities in HRQoL between HIV-positive and HIV-negative individuals in this general population sample. These findings highlight the importance of improving awareness of HIV status and expanding ART to prevent losses in HRQoL that occur with untreated HIV progression. The gains in HRQoL after individuals initiate ART could be substantial when scaled up to the population level. FundingNational Institute of Allergy and Infectious Diseases, National Institute on Drug Abuse, National Institute of Mental Health, President's Emergency Plan for AIDS Relief, International Initiative for Impact Evaluation, the Bill & Melinda Gates Foundation.

    更新日期:2017-11-10
  • Quantification of the association between malaria in pregnancy and stillbirth: a systematic review and meta-analysis
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-09-26
    Kerryn A Moore, Julie A Simpson, Michelle J L Scoullar, Rose McGready, Freya J I Fowkes
    更新日期:2017-11-10
  • Thank you to our peer reviewers
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-09-12
    Zoë Mullan

    As the scholarly community recognises Peer Review Week, and to coincide with the Peer Review Congress in Chicago, IL, USA, we once again take the opportunity to name (appendix) and thank the legion of reviewers who have given up their time to make The Lancet Global Health a better journal over the past year.

    更新日期:2017-11-10
  • Prevention and management of obstetric fistulae requires both a long-term strategy and long-term care
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-09-20
    Jeremy Torquil Wright

    Undertaking research, particularly longitudinal research, in resource-poor countries is a daunting task, and Alexandre Delamou and colleagues1 are to be congratulated on managing to collect and analyse this important dataset.

    更新日期:2017-11-10
  • Health-related quality of life of people with HIV in Zambia and South Africa
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-09-27
    Kirsten A Donald

    The face of the HIV epidemic has changed substantially across the globe in the past 10–15 years with a better rollout of effective anti-retroviral treatment (ART) across the world and in particular, in the global south where the greatest proportion of HIV-infected individuals still reside.1 As more adults and children remain relatively asymptomatic on ART, focus has moved from primarily addressing physical health, to including the promotion of optimal overall health and wellbeing. Therefore, the impact of HIV infection on health-related quality-of-life (HRQoL) would be expected to be better now than in previous years.

    更新日期:2017-11-10
  • Stillbirths: the hidden burden of malaria in pregnancy
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-09-26
    Steve M Taylor, Feiko O ter Kuile

    Globally, most stillbirths are preventable.1 An estimated 2·6 million third-trimester stillbirths occur annually, and over 90% of these stillbirths result from modifiable medical conditions. Such disorders include chronic non-communicable diseases such as obesity, hypertension, and diabetes; obstetric conditions such as advanced maternal age and post-term pregnancies; and infections such as malaria and syphilis. Given the epidemiology of these factors, stillbirths occur at the highest rates in southern Asia (25·5 per 1000 births) and sub-Saharan Africa (28·7 per 1000 births).

    更新日期:2017-11-10
  • Vaccination to reduce antimicrobial resistance
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-08
    Amy Sarah Ginsburg, Keith P Klugman

    Pneumonia remains the leading infectious cause of death in children worldwide, and how best to reduce this burden is worth consideration on World Pneumonia Day on November 12. Antibiotics are effective in treating bacterial pneumonia and access to appropriate antibiotics can be lifesaving. Universal provision of antibiotics to children younger than 5 years could prevent an estimated mean of 445 000 deaths per year due to community-acquired pneumonia—a 75·4% reduction across 101 countries.1 Antibiotics need to be available and accessible to effectively treat pneumonia; however, inappropriate use of antibiotics can lead to the emergence and progression of antibiotic resistance, a serious public health threat.

    更新日期:2017-11-09
  • Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-31
    Joshua P Vogel, Olufemi T Oladapo, Therese Dowswell, A Metin Gülmezoglu

    Post-partum haemorrhage is the leading cause of maternal mortality globally.1 The majority of deaths resulting from post-partum haemorrhage occur during the first 24 h after birth, most of which could be avoided by routine prevention through active management of the third stage of labour and prompt and effective management of post-partum haemorrhage, including the use of uterotonics and fluid replacement. Tranexamic acid, an antifibrinolytic drug, was identified as a promising candidate to be included in recommended packages for treatment of post-partum haemorrhage, since it has shown efficacy in reducing blood loss and mortality following surgical trauma.

    更新日期:2017-11-01
  • Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-26
    Oriol Mitjà, Camila González-Beiras, Charmie Godornes, Reman Kolmau, Wendy Houinei, Haina Abel, August Kapa, Raymond Paru, Sibauk V Bieb, James Wangi, Sergi Sanz, Kingsley Asiedu, Sheila A Lukehart, Quique Bassat
    更新日期:2017-10-27
  • Single-dose azithromycin to treat latent yaws
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-26
    Michael Marks, David Mabey

    Yaws, caused by Treponema pallidum subsp pertenue, was the first disease to be targeted for eradication by WHO.1 As with other treponemal infections, such as syphilis, some people develop latent infection. These individuals have positive serological test results for yaws but no clinical signs of disease. Importantly, latent yaws can relapse, which most frequently occurs in the first 5 years after infection,2 and, therefore, these people represent an important source of reinfection in endemic communities.

    更新日期:2017-10-27
  • Effect of a training and educational intervention for physicians and caregivers on antibiotic prescribing for upper respiratory tract infections in children at primary care facilities in rural China: a cluster-randomised controlled trial
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Xiaolin Wei, Zhitong Zhang, John D Walley, Joseph P Hicks, Jun Zeng, Simin Deng, Yu Zhou, Jia Yin, James N Newell, Qiang Sun, Guanyang Zou, Yan Guo, Ross E G Upshur, Mei Lin
    更新日期:2017-10-26
  • Making sense of cerebral palsy prevalence in low-income countries
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Bernard Dan, Nigel Paneth

    Much of what we know about cerebral palsy—including its effect on motor functioning, quality of life, families, and society; the importance of associated disabilities; the effectiveness of management strategies; and even fundamental epidemiological features, such as prevalence and risk factors—is derived from observations made in high-income countries (HICs). Yet, the burden of cerebral palsy is thought by many to be greater in low-income countries (LICs), for which little information is available.

    更新日期:2017-10-26
  • Prevalence of cerebral palsy in Uganda: a population-based study
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Angelina Kakooza-Mwesige, Carin Andrews, Stefan Peterson, Fred Wabwire Mangen, Ann Christin Eliasson, Hans Forssberg
    更新日期:2017-10-26
  • Reducing antibiotic prescriptions for childhood upper respiratory tract infections
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-25
    Gary W K Wong

    Resistance to antibiotics has become a major health threat worldwide, and one of the most important contributing factors is the widespread overuse of antimicrobials. This problem is most severe in low-income and middle-income countries (LMICs), where physicians have few resources for investigations and diagnosis, along with inherent concerns about missing an underlying bacterial infection. A young child usually develops between four and six episodes of upper respiratory tract infection per year.

    更新日期:2017-10-26
  • Global, regional, and country-level coverage of interventions to prevent and manage HIV and hepatitis C among people who inject drugs: a systematic review
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-23
    Sarah Larney, Amy Peacock, Janni Leung, Samantha Colledge, Matthew Hickman, Peter Vickerman, Jason Grebely, Kostyantyn V Dumchev, Paul Griffiths, Lindsey Hines, Evan B Cunningham, Richard P Mattick, Michael Lynskey, John Marsden, John Strang, Louisa Degenhardt
    更新日期:2017-10-24
  • Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic review
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-23
    Louisa Degenhardt, Amy Peacock, Samantha Colledge, Janni Leung, Jason Grebely, Peter Vickerman, Jack Stone, Evan B Cunningham, Adam Trickey, Kostyantyn Dumchev, Michael Lynskey, Paul Griffiths, Richard P Mattick, Matthew Hickman, Sarah Larney
    更新日期:2017-10-24
  • Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-11
    Seth R Flaxman, Rupert R A Bourne, Serge Resnikoff, Peter Ackland, Tasanee Braithwaite, Maria V Cicinelli, Aditi Das, Jost B Jonas, Jill Keeffe, John H Kempen, Janet Leasher, Hans Limburg, Kovin Naidoo, Konrad Pesudovs, Alex Silvester, Gretchen A Stevens, Nina Tahhan, Tien Y Wong, Hugh R Taylor, Rupert Bourne, Peter Ackland, Aries Arditi, Yaniv Barkana, Banu Bozkurt, Tasanee Braithwaite, Alain Bron, Donald Budenz, Feng Cai, Robert Casson, Usha Chakravarthy, Jaewan Choi, Maria Vittoria Cicinelli, Nathan Congdon, Reza Dana, Rakhi Dandona, Lalit Dandona, Aditi Das, Iva Dekaris, Monte Del Monte, Jenny deva, Laura Dreer, Leon Ellwein, Marcela Frazier, Kevin Frick, David Friedman, Joao Furtado, Hua Gao, Gus Gazzard, Ronnie George, Stephen Gichuhi, Victor Gonzalez, Billy Hammond, Mary Elizabeth Hartnett, Minguang He, James Hejtmancik, Flavio Hirai, John Huang, April Ingram, Jonathan Javitt, Jost Jonas, Charlotte Joslin, Jill Keeffe, John Kempen, Moncef Khairallah, Rohit Khanna, Judy Kim, George Lambrou, Van Charles Lansingh, Paolo Lanzetta, Janet Leasher, Jennifer Lim, Hans LIMBURG, Kaweh Mansouri, Anu Mathew, Alan Morse, Beatriz Munoz, David Musch, Kovin Naidoo, Vinay Nangia, Maria Palaiou, Maurizio Battaglia Parodi, Fernando Yaacov Pena, Konrad Pesudovs, Tunde Peto, Harry Quigley, Murugesan Raju, Pradeep Ramulu, Zane Rankin, Serge Resnikoff, Dana Reza, Alan Robin, Luca Rossetti, Jinan Saaddine, Mya Sandar, Janet Serle, Tueng Shen, Rajesh Shetty, Pamela Sieving, Juan Carlos Silva, Alex Silvester, Rita S. Sitorus, Dwight Stambolian, Gretchen Stevens, Hugh Taylor, Jaime Tejedor, James Tielsch, Miltiadis Tsilimbaris, Jan van Meurs, Rohit Varma, Gianni Virgili, Ya Xing Wang, Ning-Li Wang, Sheila West, Peter Wiedemann, Tien Wong, Richard Wormald, Yingfeng Zheng
    更新日期:2017-10-12
  • Global causes of vision loss in 2015: are we on track to achieve the Vision 2020 target?
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-10-11
    Charumathi Sabanayagam, Ching-Yu Cheng

    Vision impairment, including blindness, is a major public health concern in middle-aged and elderly adults worldwide, associated with diminished quality of life and increased risk of falls and death.1,2 Estimates suggest that 36 million people were blind and 217 million people had moderate or severe vision impairment worldwide in 2015.3 The Global Action Plan for 2014–19 adopted by WHO member states sets a global target of a 25% reduction in the prevalence of avoidable vision loss due to cataract and uncorrected refractive error by 2019 from the 2010 baseline level.

    更新日期:2017-10-12
  • How Ethiopia achieved Millennium Development Goal 4 through multisectoral interventions: a Countdown to 2015 case study
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Jenny Ruducha, Carlyn Mann, Neha S Singh, Tsegaye D Gemebo, Negussie S Tessema, Angela Baschieri, Ingrid Friberg, Taddese A Zerfu, Mohammed Yassin, Giovanny A Franca, Peter Berman
    更新日期:2017-10-10
  • Catastrophic costs potentially averted by tuberculosis control in India and South Africa: a modelling study
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Stéphane Verguet, Carlos Riumallo-Herl, Gabriela B Gomez, Nicolas A Menzies, Rein M G J Houben, Tom Sumner, Marek Lalli, Richard G White, Joshua A Salomon, Ted Cohen, Nicola Foster, Susmita Chatterjee, Sedona Sweeney, Inés Garcia Baena, Knut Lönnroth, Diana E Weil, Anna Vassall
    更新日期:2017-10-10
  • Association between male circumcision and women's biomedical health outcomes: a systematic review
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Jonathan M Grund, Tyler S Bryant, Inimfon Jackson, Kelly Curran, Naomi Bock, Carlos Toledo, Joanna Taliano, Sheng Zhou, Jorge Martin del Campo, Ling Yang, Apollo Kivumbi, Peizi Li, Sherri Pals, Stephanie M Davis
    更新日期:2017-10-10
  • Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Emily R Smith, Anuraj H Shankar, Lee S-F Wu, Said Aboud, Seth Adu-Afarwuah, Hasmot Ali, Rina Agustina, Shams Arifeen, Per Ashorn, Zulfiqar A Bhutta, Parul Christian, Delanjathan Devakumar, Kathryn G Dewey, Henrik Friis, Exnevia Gomo, Piyush Gupta, Pernille Kæstel, Patrick Kolsteren, Hermann Lanou, Kenneth Maleta, Aissa Mamadoultaibou, Gernard Msamanga, David Osrin, Lars-Åke Persson, Usha Ramakrishnan, Juan A Rivera, Arjumand Rizvi, H P S Sachdev, Willy Urassa, Keith P West, Noel Zagre, Lingxia Zeng, Zhonghai Zhu, Wafaie W Fawzi, Christopher R Sudfeld
    更新日期:2017-10-10
  • Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Anani Badje, Raoul Moh, Delphine Gabillard, Calixte Guéhi, Mathieu Kabran, Jean-Baptiste Ntakpé, Jérôme Le Carrou, Gérard M Kouame, Eric Ouattara, Eugène Messou, Amani Anzian, Albert Minga, Joachim Gnokoro, Patrice Gouesse, Arlette Emieme, Thomas-d'Aquin Toni, Cyprien Rabe, Baba Sidibé, Gustave Nzunetu, Lambert Dohoun, Abo Yao, Synali Kamagate, Solange Amon, Amadou-Barenson Kouame, Aboli Koua, Emmanuel Kouamé, Marcelle Daligou, Denise Hawerlander, Simplice Ackoundzé, Serge Koule, Jonas Séri, Alex Ani, Fassery Dembélé, Fatoumata Koné, Mykayila Oyebi, Nathalie Mbakop, Oyewole Makaila, Carolle Babatunde, Nathaniel Babatunde, Gisèle Bleoué, Mireille Tchoutedjem, Alain-Claude Kouadio, Ghislaine Sena, Sahinou-Yediga Yededji, Sophie Karcher, Christine Rouzioux, Abo Kouame, Rodrigue Assi, Alima Bakayoko, Serge K Domoua, Nina Deschamps, Kakou Aka, Thérèse N'Dri-Yoman, Roger Salamon, Valérie Journot, Hughes Ahibo, Timothée Ouassa, Hervé Menan, André Inwoley, Christine Danel, Serge P Eholié, Xavier Anglaret, Anani Badje, Raoul Moh, Delphine Gabillard, Calixte Guéhi, Mathieu Kabran, Jean-Baptiste Ntakpé, Jérôme Le Carrou, Gérard-Menan Kouame, Eric Ouattara, Eugène Messou, Amani Anzian, Albert Minga, Joachim Gnokoro, Patrice Gouesse, Arlette Emieme, Thomas-d'Aquin Toni, Cyprien Rabe, Baba Sidibé, Gustave Nzunetu, Lambert Dohoun, Yao Abo, Synali Kamagate, Solange Amon, Amadou-Barenson Kouame, Aboli Koua, Emmanuel Kouamé, Marcelle Daligou, Denise Hawerlander, Simplice Ackoundzé, Serge Koule, Jonas Séri, Alex Ani, Fassery Dembélé, Fatoumata Koné, Mykayila Oyebi, Nathalie Mbakop, Oyewole Makaila, Carolle Babatunde, Nathaniel Babatunde, Gisèle Bleoué, Mireille Tchoutedjem, Alain-Claude Kouadio, Ghislaine Sena, Sahinou-Yediga Yededji, Sophie Karcher, Christine Rouzioux, Abo Kouame, Rodrigue Assi, Alima Bakayoko, Serge-K. Domoua, Nina Deschamps, Kakou Aka, Thérèse N'Dri-Yoman, Roger Salamon, Valérie Journot, Hughes Ahibo, Timothée Ouassa, Hervé Ménan, André Inwoley, Ben-Ahoussi Ndja, Blandine Adou, Constance Kanga, Eba Aoussi, Emmanuel Bissagnene, Olivier Ba-Gomis, Yves-Alain Zike, Claude Akakpo, Madeleine Sassan-Morokro, Max Mobio, Bamba Doféré, Koman Mesmin, Alain Attia, Alassane Mahassadi, Apollinaire Horo, Armel Oussou, Marie-Laure Chaix, Gilles Peytavin, Mariatou Koné, Kouamé N'Guessan, Raïmi Fassassi, Serge Niangoran, Annabel Desgrées-du-Loû, France Lert, Rosemary Dray Spira, Kevin Jean, Romuald Konan, Franck Bohoussou, Cyril Yao-Yapi, Larissa N'guessan-Koffi, Bertine Siloué, Adoulaye Cissé, Adrienne Aboua, Sylvie Konan, Antoine Kouamé, Celestin N'Chot, Elvis Amani, Gwenaëlle Clouet, Bruno Debono, Geneviève Chêne, Mireille Dosso, Pierre-Marie Girard, Vincent Jarlier, Jean-Marie Masumbuko, Christian Perronne, Papa-Salif Sow, Christine Danel, Serge-Paul Eholié, Xavier Anglaret
    更新日期:2017-10-10
  • Access, Watch, and Reserve antibiotics in India: challenges for WHO stewardship
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Patricia McGettigan, Peter Roderick, Abhay Kadam, Allyson M Pollock

    In its most recent Model List of Essential Medicines,1 WHO adopted a new classification for antibiotics. This new model comprises three categories: Key Access antibiotics (eg, β-lactam, aminoglycoside, and first-generation or second-generation cephalosporin antibiotics) that “should be widely available, affordable and quality-assured”;1 Watch Group antibiotics (including most of the highest priority critically important antimicrobials for human medicine—eg, macrolides, quinolones, glycopeptides, penems, and third-generation cephalosporins)2 recommended only for specific, limited indications; and Reserve Group antibiotics (eg, fourth-generation and fifth-generation cephalosporins, aztreonam, polymixins) for situations when all alternative antibiotics have failed.

    更新日期:2017-10-10
  • Beyond divisive dichotomies in disease classification
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Felicia Marie Knaul, Octavio Gómez-Dantés, Afsan Bhadelia, Julio Frenk

    The divide between communicable and so-called non-communicable diseases (NCDs) is a pervasive, false dichotomy1 of global health. We contribute to the debate on renaming NCDs2 by proposing an integrating framework that considers both the nature of the disease and the characteristics of the required systemic response. In contrast to other renaming suggestions3 which tend to focus on dichotomy, we propose a framework that accounts for systemic responses to coexisting epidemiological profiles, comorbidities in patients, and sustained rather than episodic care.

    更新日期:2017-10-10
  • Reframing non-communicable diseases – Authors' reply
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Luke N Allen, Andrea B Feigl

    Lavanya Vijayasingham and Pascale Allotey suggest a conceptual extension of the socially transmitted condition (STC) framework to emphasise the role of social factors not only in predisposing individuals to the development of these diseases, but also in shaping the disease course and lived experience. Their reasoning is borne by evidence that socioeconomic factors correlate with STC behavioural risk factors,1 prevalence rates,2 and risk of premature death.3

    更新日期:2017-10-10
  • Reframing non-communicable diseases
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Catherine Cavalin, Alain Lescoat

    The collective dynamic initiated by Luke Allen and Andrea Feigl1 is remarkable, and explains why they felt the need to formulate a new proposal,2 which involves renaming and reframing non-communicable diseases (NCDs) as socially transmitted conditions (STCs).

    更新日期:2017-10-10
  • Reframing non-communicable diseases
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Lavanya Vijayasingham, Pascale Allotey

    In reframing non-communicable diseases (NCDs) as socially transmitted conditions bound by common upstream drivers, Luke Allen and Andrea Feigl (July, 2017),1 suggest a strong focus on the causative aspects of social context. We suggest a conceptual extension: if social factors drive the prevalence of these conditions, then social factors drive their lived consequences and course.

    更新日期:2017-10-10
  • Tackling antimicrobial resistance in neonatal sepsis
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Laura Folgori, Sally J Ellis, Julia A Bielicki, Paul T Heath, Mike Sharland, Manica Balasegaram

    The reduction of maternal and child mortality, which has halved worldwide in the past two decades, is considered one of the greatest successes of the Millennium Development Goals programme.1 However, the number of neonatal deaths has remained unacceptably high, with an estimated 2·9 million deaths every year (44% of all deaths in children younger than 5 years, worldwide).2 In 2012, the most common causes of neonatal death globally were preterm-birth complications, intrapartum-related conditions, and infections.

    更新日期:2017-10-10
  • A new public health order for Africa's health security
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    John Nkengasong, Benjamin Djoudalbaye, Olawale Maiyegun

    On July 3, 2017, African heads of state and government issued a declaration and committed to accelerating implementation of the 2005 International Health Regulations (IHR)1 and tasked the Africa Centres for Disease Control and Prevention (Africa CDC), the African Union Commission (AUC), and WHO with supporting the venture.1 The IHR is a global legal agreement that aims to prevent and respond to the spread of diseases to avoid their becoming international crises.2 The Ebola virus disease outbreak that started in March 2014, resulted in an estimated 11 000 deaths3 and US$3 billion in economic losses in west Africa.

    更新日期:2017-10-10
  • Lessons for the Sustainable Development Goals from Ethiopia's success: the case of under-5 mortality
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Yohannes Adama Melaku, Zumin Shi

    Low-income countries face many health and development challenges. In response to these challenges, world leaders have taken counter action and formulated the Millennium Development Goals (MDGs), one of which (MDG4) was to reduce the mortality of children younger than 5 years by two-thirds by 2015. In Ethiopia, under-5 mortality was 166 deaths per 1000 livebirths in 2000,1 one of the highest in the world. However, by 2016, after 15 years of successful effort, under-5 mortality had decreased to 67 deaths per 1000 livebirths.

    更新日期:2017-10-10
  • Mitigating the financial effects of tuberculosis requires more than expansion of services
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Tom Wingfield

    Reducing poverty and health inequality remains a global imperative, enshrined in the United Nation's Sustainable Development Goals. Irrespective of country of origin or residence, poorer people have increased likelihood of ill health, malnutrition, and limited access to health care.1 Few diseases better illustrate the association between health and wealth than tuberculosis, which is the archetypal disease of poverty.

    更新日期:2017-10-10
  • Effect of male circumcision on risk of sexually transmitted infections and cervical cancer in women
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Brian J Morris, Catherine A Hankins

    Current scientific evidence demonstrates compellingly that male circumcision confers a lifetime of medical and health benefits to men.1 Are there also any benefits for women who have a male sexual partner who is circumcised?

    更新日期:2017-10-10
  • Antenatal multiple micronutrient supplementation: benefits beyond iron-folic acid alone
    Lancet Glob. Health (IF 17.686) Pub Date : 2017-11-01
    Jeannine Baumgartner

    Multiple micronutrient deficiencies remain a major public health concern in low-income and middle-income countries (LMIC). Infants, young children, and women of reproductive age are especially vulnerable. Pregnancy places an additional burden on women's micronutrient status, as nutrient needs increase to meet the demands of both the mother and the developing fetus.1 Maternal micronutrient malnutrition during pregnancy can permanently affect physiological development of the fetus, which can increase the risk of morbidity, mortality, poor growth, and neurocognitive development later in life.

    更新日期:2017-10-10
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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