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A Far-Red Fluorescent Probe to Visualize Gram-Positive Bacteria in Patient Samples ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-17 Krittapas Jantarug, Vishwachi Tripathi, Benedict Morin, Aya Iizuka, Richard Kuehl, Mario Morgenstern, Martin Clauss, Nina Khanna, Dirk Bumann, Pablo Rivera-Fuentes
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Generation of Broad Protection against Influenza with Di-Tyrosine-Cross-Linked M2e Nanoclusters ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-16 Logan R. Wilks, Gaurav Joshi, Natalie Rychener, Harvinder Singh Gill
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Identification of an Optimized Clinical Development Candidate from Cilagicin, an Antibiotic That Evades Resistance by Dual Polyprenyl Phosphate Binding ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-16 Adam Rosenzweig, Kaylyn Spotton, Abir Bhattacharjee, Adrián Morales-Amador, Sean F. Brady
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Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of Mycobacterium tuberculosis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-15 Mary Nantongo, David C. Nguyen, Christopher R. Bethel, Magdalena A. Taracila, Qing Li, Khalid M. Dousa, Eunjeong Shin, Sebastian G. Kurz, Liem Nguyen, Barry N. Kreiswirth, W. Henry Boom, Mark S. Plummer, Robert A. Bonomo
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Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-12 Igor V. Esarev, Bianka Karge, Haoxuan Zeng, Petra Lippmann, Peter G. Jones, Hedda Schrey, Mark Brönstrup, Ingo Ott
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Synthesis and Anti-Chagas Activity Profile of a Redox-Active Lead 3-Benzylmenadione Revealed by High-Content Imaging ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-12 Nathan Trometer, Jérémy Pecourneau, Liwen Feng, José A. Navarro-Huerta, Danielle Lazarin-Bidóia, Sueli de Oliveira Silva Lautenschlager, Louis Maes, Amanda Fortes Francisco, John M. Kelly, Brigitte Meunier, Monica Cal, Pascal Mäser, Marcel Kaiser, Elisabeth Davioud-Charvet
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Green-Synthesized Amino Carbons for Impedimetric Biosensing of E. coli O157:H7 ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-11 Pravat Kumar Sahu, Rahul Gangwar, Asha Ramesh, Karri Trinadha Rao, Siva Rama Krishna Vanjari, Challapalli Subrahmanyam
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Bosutinib Stimulates Macrophage Survival, Phagocytosis, and Intracellular Killing of Bacteria ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-11 Ronni A. G. da Silva, Claudia J. Stocks, Guangan Hu, Kimberly A. Kline, Jianzhu Chen
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Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug Target ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-10 Jacob T. Rutherford, Kristiana Avad, Chetna Dureja, Krissada Norseeda, Bibek GC, Chenggang Wu, Dianqing Sun, Kirk E. Hevener, Julian G. Hurdle
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Bioluminescence-Based Determination of Cytosolic Accumulation of Antibiotics in Escherichia coli ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-09 Rachita Dash, Kadie A. Holsinger, Mahendra D. Chordia, Mohammad Sharifian Gh., Marcos M. Pires
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Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-06 Helena I. M. Boshoff, Katherine Young, Yong-Mo Ahn, Veena D. Yadav, Brendan M. Crowley, Lihu Yang, Jing Su, Sangmi Oh, Kriti Arora, Jenna Andrews, Michelle Manikkam, Michelle Sutphin, Anthony J. Smith, Danielle M. Weiner, Michaela K. Piazza, Joel D. Fleegle, Felipe Gomez, Emmannual K. Dayao, Brendan Prideaux, Matthew Zimmerman, Firat Kaya, Jansy Sarathy, Vee Yang Tan, Laura E. Via, Richard Tschirret-Guth
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MicroRNA-144-3p Inhibits Host Lipid Catabolism and Autophagy by Targeting PPARα and ABCA1 During Mycobacterium Tuberculosis Infection ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-05 Jing Wu, Yong Zhang, Hao Tang, Bang-Ce Ye
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Discovery of Salifungin as a Repurposed Antibiotic against Methicillin-Resistant Staphylococcus aureus with Limited Resistance Development ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-06 Chenchen Wang, Yueyue Ji, Xingyu Huo, Xiaodan Li, Wenjia Lu, Zhaoran Zhang, Wenqi Dong, Xiangru Wang, Huanchun Chen, Chen Tan
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Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-05 Inna V. Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A. Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A. Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D. Hupp, Rachael Jetson, Takashi Satoh, John T. S. Yeoman, Ying Zhang, Veronique Dartois, Dirk Schnappinger
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Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-05 Moses Andima, Annette Boese, Pascal Paul, Marcus Koch, Brigitta Loretz, Claus-Micheal Lehr
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Small Molecule IITR08367 Potentiates Antibacterial Efficacy of Fosfomycin against Acinetobacter baumannii by Efflux Pump Inhibition ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-01 Mahak Saini, Amit Gaurav, Arsalan Hussain, Ranjana Pathania
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Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-03 Pengfei She, Linhui Li, Yifan Yang, Linying Zhou, Guanqing Huang, Dan Xiao, Yong Wu
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Biophysics-Guided Lead Discovery of HBV Capsid Assembly Modifiers ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-02 Zixing Fan, Anna Pavlova, Matthew C. Jenkins, Leda Bassit, Mohammad Salman, Diane L. Lynch, Dharmeshkumar Patel, Maksym Korablyov, M. G. Finn, Raymond F. Schinazi, James C. Gumbart
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Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-02 Jessica A. Collins, Neil Osheroff
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Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-02 Pratap Vydyam, Meenal Chand, Sovitj Pou, Rolf W. Winter, Katherine M. Liebman, Aaron Nilsen, J. Stone Doggett, Michael K. Riscoe, Choukri Ben Mamoun
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Role of Macrophage PIST Protein in Regulating Leishmania major Infection ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-01 Sourav Banerjee, Mandip Pratham Gadpayle, Suman Samanta, Priyanka Dutta, Swagata Das, Rupak Datta, Sankar Maiti
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Next Generation Chemiluminescent Probes for Antimalarial Drug Discovery ACS Infect. Dis. (IF 5.3) Pub Date : 2024-04-01 Angela Hellingman, Kleopatra Sifoniou, Tamara Buser, Basil T. Thommen, Annabelle Walz, Armin Passecker, James Collins, Mario Hupfeld, Sergio Wittlin, Kathrin Witmer, Nicolas M. B. Brancucci
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Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-28 Sekar Jothi Nayaki, Arivazhagan Roja, Ramya Ravindhiran, Karthiga Sivarajan, Murugan Arunachalam, Kavitha Dhandapani
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ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-27 Zuoxi Chen, Fangzhi Du, Ruihua Zhang, Qingyun Wu, Zhiyu Lu, Rui-Li Zhang, Qianqiu Wang
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Assessing Environmental Risks during the Drug Development Process for Parasitic Vector-Borne Diseases: A Critical Reflection ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-27 Kayhan Ilbeigi, Carlos Barata, João Barbosa, Michael G. Bertram, Guy Caljon, Maria Paola Costi, Alexandra Kroll, Luigi Margiotta-Casaluci, Eli S.J. Thoré, Mirco Bundschuh
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Call for Papers: Combating Tuberculosis: Obstacles, Innovations, and the Road Ahead ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-22 Varadharajan Sundaramurthy, Erick Strauss, Jayanta Haldar
Tuberculosis (TB) is one of the oldest diseases known to humanity, as evidenced from written records and bones from different regions of the world including Mediterranean, Egypt, India, and China. Every year, World Tuberculosis Day is observed on March 24, in commemoration of Robert Koch’s announcement in 1882 of Mycobacterium tuberculosis (Mtb) as the causative agent of TB. Well over a century after
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Potent Inhibition of E. coli DXP Synthase by a gem-Diaryl Bisubstrate Analog ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-21 Lauren B. Coco, Eucolona M. Toci, Percival Yang-Ting Chen, Catherine L. Drennan, Caren L. Freel Meyers
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Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-21 Nichole K. Stewart, Marta Toth, Pojun Quan, Michael Beer, John D. Buynak, Clyde A. Smith, Sergei B. Vakulenko
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Impact of Methylthioxylose Substituents on the Biological Activities of Lipomannan and Lipoarabinomannan in Mycobacterium tuberculosis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-21 Zuzana Palčeková, Kavita De, Shiva Kumar Angala, Martine Gilleron, Sophie Zuberogoitia, Lucie Gouxette, Maritza Soto-Ojeda, Mercedes Gonzalez-Juarrero, Andrés Obregón-Henao, Jérôme Nigou, William H. Wheat, Mary Jackson
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Abiotic Small Molecule Inhibitors and Activators of the LasR Quorum Sensing Receptor in Pseudomonas aeruginosa with Potencies Comparable or Surpassing N-Acyl Homoserine Lactones ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-20 Daniel E. Manson, Gene E. Ananiev, Song Guo, Spencer S. Ericksen, Emma E. Santa, Helen E. Blackwell
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PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-19 Miaomiao Chen, Liuhua Pan, Deyuan Chen, Yueming Wu, Jianping Ye, Ke Li, Ning Zhang, Junlong Xu
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A pH Fingerprint Assay to Identify Inhibitors of Multiple Validated and Potential Antimalarial Drug Targets ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-18 Julia C. R. Lindblom, Xinxin Zhang, Adele M. Lehane
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Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-16 Haoting Li, Ansley M. Nemeth, Roberta J. Melander, Christian Melander
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Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-14 Karishma Kalera, Rachel Liu, Juhyeon Lim, Rasangi Pathirage, Daniel H. Swanson, Ulysses G. Johnson, Alicyn I. Stothard, Jae Jin Lee, Anne W. Poston, Peter J. Woodruff, Donald R. Ronning, Hyungjin Eoh, Benjamin M. Swarts
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Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-12 Julia M. Flynn, Sarah N. Zvornicanin, Tenzin Tsepal, Ala M. Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A. Schiffer, Daniel N. A. Bolon
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Recent Advances in the Development of Polymyxin Antibiotics: 2010–2023 ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-12 Cornelis J. Slingerland, Nathaniel I. Martin
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Indole Propionic Acid Disturbs the Normal Function of Tryptophanyl-tRNA Synthetase in Mycobacterium tuberculosis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-08 Xingli Han, Yamin Gao, Biao Zhou, H.M. Adnan Hameed, Cuiting Fang, Yanan Ju, Jing He, Xiange Fang, Zhiyong Liu, Wei Yu, Xiaoli Xiong, Nanshan Zhong, Tianyu Zhang
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Optimization of the Synthesis and Conjugation of the Methyl Rhamnan Tip of Pseudomonas aeruginosa A-Band Polysaccharide and Immunogenicity Evaluation for the Continued Development of a Potential Glycoconjugate Vaccine ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-06 Mohammad P. Jamshidi, Chantelle Cairns, Nam Huan Khieu, Kenneth Chan, Frank St. Michael, Andrew Cox, Janelle Sauvageau
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Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041 ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-06 Jonathan M. Turner, Caleb M. Stratton, Sandeepchowdary Bala, Maria Cardenas Alvarez, Robert A. Nicholas, Christopher Davies
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Interactions between Gepotidacin and Escherichia coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Alexandria A. Oviatt, Elizabeth G. Gibson, Jianzhong Huang, Karen Mattern, Keir C. Neuman, Pan F. Chan, Neil Osheroff
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Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Ying Fu, Shuwei Zhang, Junchao Liu, Ze Lu, Yuchao Li, Jinwen Liu, Yaping Pan
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Synergistic Augmentation of Beta-Lactams: Exploring Quinoline-Derived Amphipathic Small Molecules as Antimicrobial Potentiators against Methicillin-Resistant Staphylococcus aureus ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Surojit Ghosh, Samya Sen, Moumita Jash, Satyajit Ghosh, Aniket Jana, Rajsekhar Roy, Nabanita Mukherjee, Dipro Mukherjee, Jayita Sarkar, Surajit Ghosh
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Update on Journal Scope, Editorial Team, and Advisory Board Members for ACS Infectious Diseases ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Jayanta Haldar
Dear Readers, As we step into the 10th year of publication of ACS Infectious Diseases, it is with great enthusiasm that I share with you some pivotal developments related to our journal. In response to the ever-expanding landscape of infectious diseases research, we have undertaken an initiative to broaden our scope, to encompass a wide spectrum of topics. In addition to the existing themes of the
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Investigation of Siderophore–Platinum(IV) Conjugates Reveals Differing Antibacterial Activity and DNA Damage Depending on the Platinum Cargo ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-04 Chuchu Guo, Kwo-Kwang A. Wang, Elizabeth M. Nolan
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Target-Mediated Fluoroquinolone Resistance in Neisseria gonorrhoeae: Actions of Ciprofloxacin against Gyrase and Topoisomerase IV ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-04 Jessica A. Collins, Alexandria A. Oviatt, Pan F. Chan, Neil Osheroff
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Peptide Dendrimer-Based Antibacterial Agents: Synthesis and Applications ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-01 Suchita Paul, Sandeep Verma, Yu-Chie Chen
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Protein O-Fucosyltransferase Is Required for the Efficient Invasion of Hepatocytes by Plasmodium berghei Sporozoites ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-29 Pratik Narain Srivastava, Plabita Paul, Satish Mishra
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Holistic One Health Surveillance Framework: Synergizing Environmental, Animal, and Human Determinants for Enhanced Infectious Disease Management ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-28 Samradhi Singh, Poonam Sharma, Namrata Pal, Devojit Kumar Sarma, Rajnarayan Tiwari, Manoj Kumar
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Synergistic Binding of SARS-CoV-2 to ACE2 and Gangliosides in Native Lipid Membranes ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-27 Manorama Dey, Anurag Sharma, Garvita Dhanawat, Divya Gupta, Krishnan H. Harshan, Nagma Parveen
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Proteomic Analysis of the Mycobacterium tuberculosis Outer Membrane for Potential Implications in Uptake of Small Molecules ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-24 Aseem Palande, Saniya Patil, Anjali Veeram, Soumya Swastik Sahoo, Tejan Lodhiya, Pankaj Maurya, Balaji Muralikrishnan, Jeetender Chugh, Raju Mukherjee
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Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-22 Li Zhou, Ruochuan Liu, Heather Pathak, Xiaoyu Wang, Geon H. Jeong, Pratima Kumari, Mukesh Kumar, Jun Yin
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Understanding Antisense Oligonucleotide Efficiency in Inhibiting Prokaryotic Gene Expression ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-22 Sandra Story, Sayantan Bhaduri, Sudakshina Ganguly, Rambabu Dakarapu, Sarah L. Wicks, Jhuma Bhadra, Simeon Kwange, Dev P. Arya
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High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-17 Sandra Johannsen, Robin M. Gierse, Arne Krüger, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha de Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie Alvarez, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa de Souza, Melloney Dröge, Bernard van Vliet, Jack den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John,
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Characterization of a Myeloid Differentiation Factor 2-Derived Peptide that Facilitates THP-1 Macrophage-Mediated Phagocytosis of Gram-Negative Bacteria ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-16 Anshika Tandon, Munesh Kumar Harioudh, Neeraj Kumar Verma, Jyotshana Saroj, Arvind Gupta, Garima Pant, Jitendra Kumar Tripathi, Amit Kumar, Tripti Kumari, Amit Kumar Tripathi, Kalyan Mitra, Jimut Kanti Ghosh
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N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-12 Pankaj S. Mahajan, Steven J. Smith, Min Li, Robert Craigie, Stephen H. Hughes, Xue Zhi Zhao, Terrence R. Burke, Jr.
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Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-09 Ashleigh S. Paparella, Isabella Brew, Huynh A. Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C. Tyler, Vern L. Schramm
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Antifungal and Antiparasitic Activities of Metallocene-Containing Fluconazole Derivatives ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-08 Yan Lin, Gonzalo Scalese, Christina A. Bulman, Robin Vinck, Olivier Blacque, Margot Paulino, Andres Ballesteros-Casallas, Leticia Pérez Díaz, Gustavo Salinas, Makedonka Mitreva, Tobias Weil, Kevin Cariou, Judy A. Sakanari, Dinorah Gambino, Gilles Gasser
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Extracellular Vesicles in Malaria: Shedding Light on Pathogenic Depths ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-06 Sangita Dey, Salini Mohapatra, Manoj Khokhar, Sana Hassan, Rajan Kumar Pandey
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Interleukin-22 Contributes to Blood–Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-06 Ruicheng Yang, Jiaqi Chen, Xinyi Qu, Hulin Liu, Xinyi Wang, Chen Tan, Huanchun Chen, Xiangru Wang
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Rational Design of a Potent Antimicrobial Peptide Based on the Active Region of a Gecko Cathelicidin ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-05 Ying Cai, Xingyu Wang, Tianyu Zhang, An Yan, Lin Luo, Chenxi Li, Gengzhou Tian, Zhongxiang Wu, Xi Wang, Dong Shen, Yajun Han, Zhiye Zhang