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Brain-Permeable Immunoproteasome-Targeting Macrocyclic Peptide Epoxyketones for Alzheimer’s Disease J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Ji Eun Park, Chhabi L. Chaudhary, Deepak Bhattarai, Kyung Bo Kim
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Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Esra Balıkçı, Anne-Sophie M. C. Marques, Ludwig G. Bauer, Raina Seupel, James Bennett, Brigitt Raux, Karly Buchan, Klemensas Simelis, Usha Singh, Catherine Rogers, Jennifer Ward, Carol Cheng, Tamas Szommer, Kira Schützenhofer, Jonathan M. Elkins, David L. Sloman, Ivan Ahel, Oleg Fedorov, Paul E. Brennan, Kilian V. M. Huber
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Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Mengyang Chang, Feng Gao, Giri Gnawali, Hang Xu, Yue Dong, Xiang Meng, Wenpan Li, Zhiren Wang, Byrdie Lopez, Jennifer S. Carew, Steffan T. Nawrocki, Jianqin Lu, Qing-Yu Zhang, Wei Wang
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Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Xue-Qing Song, Xu Guo, Yi-Xin Ding, Yi-Xuan Han, Zhi-Hao You, Yali Song, Yanan Yuan, Longfei Li
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Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Rajendra Rohokale, Jiatong Guo, Zhongwu Guo
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Arene–Arene Coupled Disulfamethazines (or Sulfadiazine)-Phenanthroline-Metal(II) Complexes were Synthesized by In Situ Reactions and Inhibited the Growth and Development of Triple-Negative Breast Cancer through the Synergistic Effect of Antiangiogenesis, Anti-Inflammation, Pro-Apoptosis, and Cuproptosis J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Bing-Bing Xu, Nan Jin, Ji-Cheng Liu, Ai-Qiu Liao, Hong-Yu Lin, Xiu-Ying Qin
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Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-04-18 Ting-Ting Liu, Qing Wang, Yuxing Zhou, Baixin Ye, Tingting Liu, Linyang Yan, Jinbao Fan, Jiahao Xu, Yingjun Zhou, Zanxian Xia, Xu Deng
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Discovery of a Potent Dual Son of Sevenless 1 (SOS1) and Epidermal Growth Factor Receptor (EGFR) Inhibitor for the Treatment of Prostate Cancer J. Med. Chem. (IF 7.3) Pub Date : 2024-04-17 Lufeng Zheng, Yuxin Zhang, Shuang Mei, Tianyuan Xie, Yunting Zou, Yuting Wang, Han Jing, Shengtao Xu, Pierre Dramou, Zhen Xu, Jindong Li, Yang Zhou, Miao-Miao Niu
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Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-04-17 Sven Falke, Julia Lieske, Alexander Herrmann, Jure Loboda, Katarina Karničar, Sebastian Günther, Patrick Y. A. Reinke, Wiebke Ewert, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Klemen Dretnik, Hideaki Tsuge, Vito Turk, Henry N. Chapman, Winfried Hinrichs, Gregor Ebert, Dušan Turk, Alke Meents
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Design, Synthesis, and Biological Evaluation of β-Trifluoroethoxydimethyl Selenides as Potent Antiosteoporosis Agents J. Med. Chem. (IF 7.3) Pub Date : 2024-04-17 Yao Wu, Bin Li, Linkun Ying, Yao Chen, Yuxin Zhang, Chaoming Hu, Yichi Zhang, Lele Yi, Weiwei Xue, Shengbin Huang, Zengqiang Song
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Synthesis and Structure–Activity Relationships for Glutamate Transporter Allosteric Modulators J. Med. Chem. (IF 7.3) Pub Date : 2024-04-16 Andréia C. K. Fontana, Adi N.R. Poli, Jitendra Gour, Yellamelli V.V. Srikanth, Nicholas Anastasi, Devipriya Ashok, Apeksha Khatiwada, Katelyn L. Reeb, Mary Hongying Cheng, Ivet Bahar, Scott M. Rawls, Joseph M. Salvino
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Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-16 Bo-Xin Zheng, Wei Long, Wende Zheng, Yaoxun Zeng, Xiao-Chun Guo, Ka-Hin Chan, Meng-Ting She, Alan Siu-Lun Leung, Yu-Jing Lu, Wing-Leung Wong
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Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-15 Tonia Kirschner, Matthias P. Müller, Daniel Rauh
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Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity J. Med. Chem. (IF 7.3) Pub Date : 2024-04-15 Xinrong Xiang, Zhengyi Dai, Baozhu Luo, Ninglin Zhao, Song Liu, Jing Sui, Jiasheng Huang, Yuanzheng Zhou, Jinlong Gu, Jiangnan Zhang, Tao Yang, Rui Bao, Youfu Luo
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Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3′-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury J. Med. Chem. (IF 7.3) Pub Date : 2024-04-15 Mingjie Chen, Shuyue Lei, Zihua Zhou, Meng Wang, Chunlan Feng, Xiaoling Gao, Chunyong Ding, Zilan Song, Wei Tang, Ao Zhang
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Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs J. Med. Chem. (IF 7.3) Pub Date : 2024-04-13 Yanying Sun, Zhenzhen Zhou, Na Wang, Fabao Zhao, Ying Liu, Xiaoxuan Xu, Xiaohan Wang, Zhenbang Gou, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
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Iridium(III)-Based PD-L1 Agonist Regulates p62 and ATF3 for Enhanced Cancer Immunotherapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-13 Dongping Deng, Mengmeng Wang, Yan Su, Hongbao Fang, Yuncong Chen, Zhi Su
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Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-04-13 Wen Shuai, Huan Xiao, Panpan Yang, Yiwen Zhang, Faqian Bu, Yongya Wu, Qiu Sun, Guan Wang, Liang Ouyang
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Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader J. Med. Chem. (IF 7.3) Pub Date : 2024-04-12 Md Kabir, Lihuai Qin, Kaixiu Luo, Yan Xiong, Rebecca A. Sidi, Kwang-Su Park, Jian Jin
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Molecular Imaging of Alzheimer’s Disease-Related Sigma-1 Receptor in the Brain via a Novel Ru-Mediated Aromatic 18F-deoxyfluorination Probe J. Med. Chem. (IF 7.3) Pub Date : 2024-04-12 Ping Bai, Frederick A. Bagdasarian, Yulong Xu, Yanli Wang, Yongle Wang, Ashley Gomm, Yanting Zhou, Rui Wu, Hsiao-Ying Wey, Rudolph E. Tanzi, Can Zhang, Yu Lan, Changning Wang
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Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease J. Med. Chem. (IF 7.3) Pub Date : 2024-04-12 Yugendar R. Alugubelli, Jing Xiao, Kaustav Khatua, Sathish Kumar, Long Sun, Yuying Ma, Xinyu R. Ma, Veerabhadra R. Vulupala, Sandeep Atla, Lauren R. Blankenship, Demonta Coleman, Xuping Xie, Benjamin W. Neuman, Wenshe Ray Liu, Shiqing Xu
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Discovery of the First-in-Class G9a/GLP PROTAC Degrader J. Med. Chem. (IF 7.3) Pub Date : 2024-04-11 Julia Velez, Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang-su Park, Md Kabir, H. Ümit Kaniskan, Yan Xiong, Jian Jin
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Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles J. Med. Chem. (IF 7.3) Pub Date : 2024-04-11 Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin Peter Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A. Laufer, Stefan Knapp, Daniel Dauch, Matthias Gehringer
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Comparative Study of Sonodynamic and Photoactivated Cancer Therapies with Re(I)-Tricarbonyl Complexes Comprising Phenanthroline Ligands J. Med. Chem. (IF 7.3) Pub Date : 2024-04-11 Rajesh Kushwaha, Virendra Singh, Silda Peters, Ashish Kumar Yadav, Tumpa Sadhukhan, Biplob Koch, Samya Banerjee
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Targeting Myeloid Leukemia-1 in Cancer Therapy: Advances and Directions J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 Hongguang Deng, Yu Han, Liang Liu, Hong Zhang, Dan Liu, Jiachen Wen, Min Huang, Linxiang Zhao
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Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 Zhijie Wang, Lin Yuan, Xiaotong Liao, Xia Guo, Jianjun Chen
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Discovery of a Novel Potent Tetrazole Antifungal Candidate with High Selectivity and Broad Spectrum J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 Tingjunhong Ni, Yumeng Hao, Zichao Ding, Xiaochen Chi, Fei Xie, Ruina Wang, Junhe Bao, Lan Yan, Liping Li, Ting Wang, Dazhi Zhang, Yuanying Jiang
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Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 Yinyong Zhang, Dan Zhang, Wenhao Zhao, Hongyuan Li, Zhengyu Lu, Bin Guo, Xin Meng, Xianli Zhou, Yushe Yang
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Potentiating Activity of GmhA Inhibitors on Gram-Negative Bacteria J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 François Moreau, Dmytro Atamanyuk, Markus Blaukopf, Marek Barath, Mihály Herczeg, Nuno M. Xavier, Jérôme Monbrun, Etienne Airiau, Vivien Henryon, Frédéric Leroy, Stéphanie Floquet, Damien Bonnard, Robert Szabla, Chris Brown, Murray S. Junop, Paul Kosma, Vincent Gerusz
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Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington, Haris Jahic, Janid A. Ali, Charles B. Davis, Shanzhong Gong, Deepali Gotur, Lina Gu, Patrick McCarren, Matthew R. Tonini, Alice Tsai, Erik W. Wilker, Hongling Yuan, Minjie Zhang, Wenhai Zhang, Alan Huang, John P. Maxwell
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Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β-Lactams against Gram-Negative Bacteria J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 Fangjun Liu, Qunhuan Kou, Hongyuan Li, Yangzhi Cao, Meng Chen, Xin Meng, Yinyong Zhang, Ting Wang, Hui Wang, Dan Zhang, Yushe Yang
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Correction to “Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure–Activity Relationships of the Novel PPP4pT Series’’ J. Med. Chem. (IF 7.3) Pub Date : 2024-04-10 Tharushi P. Wijesinghe, Busra Kaya, Miguel A. Gonzálvez, Jeffrey R. Harmer, Mahan Gholam Azad, Paul V. Bernhardt, Mahendiran Dharmasivam, Des R. Richardson
Page 15472. In the Acknowledgments, a funding body was inadvertently omitted, although their support played a pivotal role in the successful completion of this research endeavor. The following should be added as the fourth sentence in the published article’s Acknowledgments section: D.R.R. appreciates a Senior Research Grant from Tour de Cure – Soiree for a Cure 2021. This article has not yet been
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Synthesis and Structure–Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist J. Med. Chem. (IF 7.3) Pub Date : 2024-04-09 Geoffrey B. Varty, Clinton E. Canal, Tina A. Mueller, Joshua A. Hartsel, Richa Tyagi, Ken Avery, Michael E. Morgan, Amy C. Reichelt, Pradip Pathare, Erik Stang, Michael G. Palfreyman, Alex Nivorozhkin
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Discovery of a Novel CSF-1R Inhibitor with Highly Improved Pharmacokinetic Profiles and Superior Efficacy in Colorectal Cancer Immunotherapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-09 Qi Lv, Hongqiong Yang, Dan Wang, Haikun Zhou, Juan Wang, Yishu Zhang, Dapeng Wu, Ying Xie, Yingshan Lv, Lihong Hu, Junwei Wang
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Promising Anticancer Prodrugs Based on Pt(IV) Complexes with Bis-organosilane Ligands in Axial Positions J. Med. Chem. (IF 7.3) Pub Date : 2024-04-09 Francisco Navas, Ana Chocarro-Calvo, Patricia Iglesias-Hernández, Paloma Fernández-García, Victoria Morales, José Manuel García-Martínez, Raúl Sanz, Antonio De la Vieja, Custodia García-Jiménez, Rafael A. García-Muñoz
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Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target J. Med. Chem. (IF 7.3) Pub Date : 2024-04-09 Sarah Wazir, Tomi A. O. Parviainen, Jessica J. Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Sven T. Sowa, Albert Galera-Prat, Dana Ferraris, Mirko M. Maksimainen, Anthony R. Fehr, Juha P. Heiskanen, Lari Lehtiö
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Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises J. Med. Chem. (IF 7.3) Pub Date : 2024-04-09 Kosmas Alexandros Pervanidis, Giovanni Danilo D’Angelo, Jörn Weisner, Sven Brandherm, Daniel Rauh
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Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer J. Med. Chem. (IF 7.3) Pub Date : 2024-04-08 Tatiana J. Carneiro, Ana L. M. Batista de Carvalho, Martin Vojtek, Raquel C. Laginha, Maria Paula M. Marques, Carmen Diniz, Ana M. Gil
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Design and Synthesis of Novel Ultralong-Acting Peptides as EDP-EBP Interaction Inhibitors for Pulmonary Fibrosis Treatment J. Med. Chem. (IF 7.3) Pub Date : 2024-04-08 Yixiang Wang, Fanghan Xue, Wei Cheng, Qian Zhao, Nazi Song, Zihan Shi, Han Liu, Yu Li, Qinglin Tang, Qi Liu, Yiqing Wang, Fangfang Zhang, Xianxing Jiang
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Multifunctional Lipidated Protein Carrier with a Built-In Adjuvant as a Universal Vaccine Platform Potently Elevates Immunogenicity of Weak Antigens J. Med. Chem. (IF 7.3) Pub Date : 2024-04-08 Shi-Hao Zhou, Ru-Yan Zhang, Yu Wen, Yong-Ke Zou, Dong Ding, Miao-Miao Bian, Hong-Ying Cui, Jun Guo
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Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors J. Med. Chem. (IF 7.3) Pub Date : 2024-04-08 Pengpeng Niu, Yanxin Tao, Guohao Lin, Huiqi Xu, Qingyuan Meng, Kang Yang, Weixue Huang, Meiru Song, Ke Ding, Dawei Ma, Mengyang Fan
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Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy J. Med. Chem. (IF 7.3) Pub Date : 2024-04-08 Binbin Cheng, Yaru Shi, Chuxiao Shao, Shuanghu Wang, Zhenhong Su, Jin Liu, Yingxing Zhou, Xiaoting Fei, Wei Pan, Jianjun Chen, Yiyu Lu, Jian Xiao
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Identification of Cellular Protein Targets of a Half-Sandwich Iridium(III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses J. Med. Chem. (IF 7.3) Pub Date : 2024-04-05 Robin Ramos, Anthi Karaiskou, Candice Botuha, Sadek Amhaz, Michaël Trichet, Florent Dingli, Jérémy Forté, France Lam, Alexis Canette, Chloé Chaumeton, Murielle Salome, Thomas Chenuel, Céline Bergonzi, Philippe Meyer, Sylvain Bohic, Damarys Loew, Michèle Salmain, Joëlle Sobczak-Thépot
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Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death J. Med. Chem. (IF 7.3) Pub Date : 2024-04-05 Ganga Reddy Velma, Isabella S. Krider, Erick T. M. Alves, Jenna M. Courey, Megan S. Laham, Gregory R. J. Thatcher
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Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia J. Med. Chem. (IF 7.3) Pub Date : 2024-04-05 Yongmei Tang, Yanan Zheng, Xueping Hu, Huajun Zhao, Sunliang Cui
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Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance J. Med. Chem. (IF 7.3) Pub Date : 2024-04-04 Meng Wang, Guimei Li, Guiyang Jiang, Jinyuan Cai, Zhikun Liu, Rizhen Huang, Xiaochao Huang, Hengshan Wang
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Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma J. Med. Chem. (IF 7.3) Pub Date : 2024-04-04 Zhihao Liu, Min Lin, Chenyu Liu, Xin Chen, Qian Chen, Xinyu Li, Xiaoyan Wu, Yahui Wang, Lei Wang, Fan Yang, Cheng Luo, Jia Jin, Fei Ye
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Toward More Selective Antibiotic Inhibitors: A Structural View of the Complexed Binding Pocket of E. coli Peptide Deformylase J. Med. Chem. (IF 7.3) Pub Date : 2024-04-04 Hendrik Kirschner, Nicole Heister, Manuela Zouatom, Tianyi Zhou, Eckhard Hofmann, Jürgen Scherkenbeck, Raphael Stoll
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Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds J. Med. Chem. (IF 7.3) Pub Date : 2024-04-04 Ashley L. Ramos, Eric R. Goedken, Kristine E. Frank, Maria A. Argiriadi, Sana Bazzaz, Zhiguo Bian, Jesse T. C. Brown, Paolo A. Centrella, Hui-Ju Chen, Jeremy S. Disch, Pamela L. Donner, David B. Duignan, Diana Gikunju, Stephen N. Greszler, Marie-Aude Guié, Sevan Habeshian, Hajnalka E. Hartl, Christopher D. Hein, Charles W. Hutchins, Rachael Jetson, Anthony D. Keefe, Hasan Khan, Huan-Qiu Li, Allison
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Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia J. Med. Chem. (IF 7.3) Pub Date : 2024-04-04 Li’ao Zhang, Wenjun Hu, Huimin Guo, Qiushuang Sun, Xi Xu, Zhiyu Li, Zhixia Qiu, Jinlei Bian
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Design, Synthesis, and In Vivo Evaluation of Isosteviol Derivatives as New SIRT3 Activators with Highly Potent Cardioprotective Effects J. Med. Chem. (IF 7.3) Pub Date : 2024-04-04 Zhenyu Chen, Zhiyin Li, Ruilong Xu, Yufeng Xie, Dehuai Li, Yu Zhao
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Development and Initial Characterization of the First 18F-CXCR2-Targeting Radiotracer for PET Imaging of Neutrophils J. Med. Chem. (IF 7.3) Pub Date : 2024-04-03 Philipp Spatz, Xinyu Chen, Kora Reichau, Max E. Huber, Saskia Mühlig, Yohji Matsusaka, Matthias Schiedel, Takahiro Higuchi, Michael Decker
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Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo J. Med. Chem. (IF 7.3) Pub Date : 2024-04-03 Qi-xuan Huang, Da-meng Fan, Zao-zao Zheng, Ting Ran, Ao Bai, Rong-quan Xiao, Guo-sheng Hu, Wen Liu
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Novel CDK19-Targeted Radiotracers: A Potential Design Strategy to Improve the Pharmacokinetics and Tumor Uptake J. Med. Chem. (IF 7.3) Pub Date : 2024-04-03 Dong Dai, Jiang Yu, Wenfeng Gou, Shuangmeng Yang, Yanli Li, Ziyang Wang, Zhao Yang, Ting Huang, Panfeng Li, Tong Zhu, Wenbin Hou, Yu Zhao, Wengui Xu, Yiliang Li
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Pharmacokinetics Profiler (PhaKinPro): Model Development, Validation, and Implementation as a Web Tool for Triaging Compounds with Undesired Pharmacokinetics Profiles J. Med. Chem. (IF 7.3) Pub Date : 2024-04-03 Marielle Rath, James Wellnitz, Holli-Joi Martin, Cleber Melo-Filho, Joshua E. Hochuli, Guilherme Martins Silva, Jon-Michael Beasley, Maxfield Travis, Zoe L. Sessions, Konstantin I. Popov, Alexey V. Zakharov, Artem Cherkasov, Vinicius Alves, Eugene N. Muratov, Alexander Tropsha
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Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)–Arene Complexes J. Med. Chem. (IF 7.3) Pub Date : 2024-04-03 Athi Welsh, Karabo Serala, Sharon Prince, Gregory S. Smith
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Development of an Imidazopyridazine-Based MNK1/2 Inhibitor for the Treatment of Lymphoma J. Med. Chem. (IF 7.3) Pub Date : 2024-04-02 Xinrui Yuan, Dezhong Guan, Chao Chen, Shi Guo, Hanshu Wu, Hong Bu, Chao-Yie Yang, Mian Wang, Jinpei Zhou, Huibin Zhang
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Design, Synthesis, and Biological Evaluation of 2-Phenoxyalkylhydrazide Benzoxazole Derivatives as Quorum Sensing Inhibitors with Strong Antibiofilm Effect J. Med. Chem. (IF 7.3) Pub Date : 2024-04-02 Panpan Zhang, Yangchun Ma, Yingmei Wang, Enhui Dong, Shutao Ma
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Correction to “A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria” J. Med. Chem. (IF 7.3) Pub Date : 2024-04-02 Dongliang Guan, Jiaxiang Liu, Feifei Chen, Jian Li, Xiaowen Wang, Weiwei Lu, Yanrui Suo, Feng Tang, Lefu Lan, Xiaojie Lu, Wei Huang
Page 3784. An inadvertent error during the proofreading process resulted in the unintentional deletion of activity data for compounds listed in Table 1. The complete Table 1 is presented here. Mu50: a strain of vancomycin-intermediate-resistant S. aureus (VISA) isolated in Japan; 0649 (Efm-HS-0649): a strain of vancomycin-resistant E. faecium (VRE) isolated in China. The R1 and R2 groups used in derivatives
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Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment J. Med. Chem. (IF 7.3) Pub Date : 2024-04-02 Nanxia Zhang, Shige Shen, Mengyu Yang, Sijie He, Chunxiao Liu, Hongmei Li, Tao Lu, Haichun Liu, Qinghua Hu, Weifang Tang, Yadong Chen