An efficient and novel method for the synthesis of α-ketoesters has been developed via oxidative coupling of acetophenones with alcohols under TBHP/I₂/DBU conditions in a microfluidic chip reactor, which has a wide substrate scope, uses a lower dosage of iodine and affords higher product yields in only a few seconds. Moreover, a scale-up continuous flow system is also feasible and the plausible reaction mechanism has been proposed based on a series of control experiments.

中文翻译：

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在无金属条件下通过苯乙酮与醇的氧化偶联微流体合成α-酮酸酯

在微流体芯片反应器中，在TBHP / I ₂ / DBU条件下，通过苯乙酮与醇的氧化偶联，已经开发出一种高效且新颖的合成α-酮酸酯的方法，该方法具有较宽的底物范围，使用较低的碘量和仅需几秒钟即可提供更高的产品产量。此外，按比例放大的连续流系统也是可行的，并且已经通过一系列控制实验提出了合理的反应机理。