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Lipidomic profiles of Drosophila melanogaster and cactophilic fly species: models of human metabolic diseases
Integrative Biology ( IF 2.5 ) Pub Date : 2017-10-02 00:00:00 , DOI: 10.1039/c7ib00155j
Daniel Cázarez-García 1, 2, 3, 4 , Mariana Ramírez Loustalot-Laclette 3, 4, 5 , Therese Ann Markow 3, 4, 5 , Robert Winkler 1, 2, 3, 4
Affiliation  

The metabolic syndrome (MetS) is associated with serious diseases and represents an important threat for global public health. The common fruit fly (Drosophila melanogaster) has served as a model organism to study physiological processes of the MetS, because central metabolic pathways are conserved among species, and because the flies are easy to cultivate in a laboratory. In nature, D. melanogaster is a fruit generalist, feeding on diets rich in simple carbohydrates. Other Drosophilids, however, have specialized on distinct resources. Drosophila mojavensis, for example, is endemic to the Sonoran Desert, where it feeds on necrotic cacti which are low in carbohydrates. It’s close relative, Drosophila arizonae is cactophilic as well, but also is found breeding in fruits containing simple sugars. Previous studies have shown that high-sugar diets negatively affect the larval development of D. mojavensis and increase their triglyceride content, compared to D. melanogaster. More general metabolic profiles, in response to these different diets, however, have yet to be produced for any of the species. In addition, because D. arizonae appears somewhat intermediate to D. melanogaster and D. mojavensis in their development times and survival under the above mentioned diets, its general metabolic profiles also are of interest. Thus, in the present study we ask to what extent the general metabolism of these three different Drosophila species is affected by diets of distinct protein-sugar ratios. To obtain an un-biased view on possibly novel phenomena, we combined untargeted metabolomics with Random Forest data mining.

中文翻译:

果蝇和拟蝇蝇类的脂质谱:人类代谢疾病的模型

代谢综合症(MetS)与严重疾病有关,对全球公共健康构成重要威胁。常见的果蝇(果蝇(Drosophila melanogaster))已成为研究MetS生理过程的模型生物,因为物种之间的中央代谢途径是保守的,而且果蝇易于在实验室中培养。在自然界中,黑腹果蝇是一种水果通才,以富含简单碳水化合物的饮食为食。但是,其他果蝇类则专门研究独特的资源。例如,果蝇是索诺兰沙漠的特有种,它以碳水化合物含量低的坏死仙人掌为食。亲缘关系密切,果蝇也有嗜酸性,但也发现在含有单糖的水果中繁殖。以前的研究表明,与黑腹果蝇相比,高糖饮食对莫氏果蝇的幼虫发育有不利影响,并增加了其甘油三酸酯含量。然而,尚未针对任何物种产生响应于这些不同饮食的更一般的代谢概况。另外,由于在上述饮食下,亚利桑那D. melanogaster和D. mojavensis在其发育时间和存活率上似乎在中间居于D. melanogaster和D. mojavensis的中间,因此它的总体代谢特性也很受关注。因此,在本研究中,我们询问这三种不同的果蝇物种的总体代谢在多大程度上受到蛋白质-糖比不同的饮食的影响。为了获得对可能新颖现象的无偏见,我们将无目标代谢组学与随机森林数据挖掘相结合。
更新日期:2017-10-02
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