Rationale The early detection of primary tumours and metastatic disease is vital for successful therapy and is contingent upon highly specific molecular markers and sensitive, non-invasive imaging techniques. We hypothesized that the accumulation of activated platelets within tumours is a general phenomenon and thus represents a novel means for the molecular imaging of cancer. Here we investigate a unique single chain antibody (scFv), which specifically targets activated platelets, as a novel biotechnological tool for molecular imaging of cancer.

中文翻译：

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靶向活化的血小板：癌症成像的独特且潜在的通用方法

原理早期发现原发性肿瘤和转移性疾病对于成功治疗至关重要，并且取决于高度特异性的分子标记和敏感的非侵入性成像技术。我们假设肿瘤中活化血小板的积累是一种普遍现象，因此代表了一种用于癌症分子成像的新颖手段。在这里，我们研究一种独特的单链抗体（scFv），它专门针对活化的血小板，作为一种新型的生物技术工具，用于癌症分子成像。