Cancer is one of the leading causes of death worldwide. Many treatments have been developed so far, although effective, suffer from severe side effects due to low selectivity. Nanoparticles can improve the therapeutic index of their delivered drugs by specifically transporting them to tumors. However, their exogenous nature usually leads to fast clearance by mononuclear phagocytic system. Recently, cell membrane-camouflaged nanoparticles have been investigated for cancer therapy, taking advantages of excellent biocompatibility and versatile functionality of cell membranes. In this review, we summarized source materials and procedures that have been used for constructing and characterizing biomimetic nanoparticles with a focus on their application in cancer therapy.

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细胞膜伪装纳米粒子的制备及其在癌症治疗中的应用

癌症是全世界死亡的主要原因之一。迄今为止，已经开发出许多治疗方法，尽管有效，但由于选择性低而产生严重的副作用。纳米颗粒可以通过将药物特异性转运至肿瘤来提高其治疗指数。然而，它们的外源性通常导致单核吞噬系统快速清除。最近，利用细胞膜优异的生物相容性和多功能性，细胞膜伪装纳米颗粒已被研究用于癌症治疗。在这篇综述中，我们总结了用于构建和表征仿生纳米粒子的源材料和程序，重点关注其在癌症治疗中的应用。