Thermoresponsive polymers change their physical properties as the temperature is changed and have found extensive use in a number of fields, especially in tissue engineering and in the development of drug delivery systems. The synthesis of a novel core–shell nanogel composed of N‐isopropylacrylamide and sulfobetaine by reversible addition fragmentation chain transfer polymerization is reported. The core–shell architecture of the nanogels is confirmed using energy dispersive X‐ray spectroscopy in scanning transmission electron microscopy. These nanogels exhibit dual thermoresponsive behavior, i.e., the core of the nanogel exhibits lower critical solution temperature, while the shell displays upper critical solution temperature behavior. Transition temperatures can be easily tuned by changing the molecular weight of the constituent polymer. These nanogels can be efficiently used in temperature‐triggered delivery of therapeutic proteins and drugs.

中文翻译：

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具有UCST和LCST行为的可调双热响应核-壳纳米凝胶

随着温度变化，热响应性聚合物会改变其物理性质，并已在许多领域得到广泛应用，尤其是在组织工程和药物输送系统的开发中。由N组成的新型核壳纳米凝胶的合成报道了异丙基丙烯酰胺和磺基甜菜碱通过可逆加成断裂链转移聚合反应。纳米凝胶的核-壳结构已通过扫描透射电子显微镜中的能量色散X射线光谱法得到证实。这些纳米凝胶表现出双重热响应行为，即，纳米凝胶的核心表现出较低的临界溶液温度，而壳表现出较高的临界溶液温度行为。通过改变组成聚合物的分子量可以很容易地调节转变温度。这些纳米凝胶可有效地用于温度触发的治疗性蛋白质和药物的递送。