While reloadable drug delivery platforms are highly prized for the treatment of a broad spectrum of diseases, the gel–gel interface between hydrogels hinders the intergel diffusive transport of drugs and thus limits the application of hydrogels as reloadable depots. Here, this study reports the circumvention of this barrier by employing a self‐healing hydrogel prepared from N‐carboxyethyl chitosan and sodium alginate dialdehyde, which are cross‐linked via a reversible Schiff base linkage. The injectable and bioadhesive hydrogel shows a rapid gelation time of 47 s. The dynamic self‐healing process enables the efficient diffusive transport of carbon quantum dots (C‐dots) into an adjacent hydrogel, and thus, the C‐dots can be used to scavenge reactive oxygen species from a remote inflammation site. Specifically, the diffusive transport of the C‐dots in the self‐healing hydrogel after three sequential reloading steps is sevenfold greater than that in the non‐self‐healing counterpart. In vivo, hematoxylin and eosin staining of the murine skin at the injection site shows no apparent symptoms of inflammation in the group treated with the reloadable self‐healing hydrogel. The current strategy represents a promising and straightforward route for the design of a reloadable drug delivery system for future use in clinical application.

中文翻译：

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可重载的自愈水凝胶，可跨胶体-凝胶界面扩散C点，以清除活性氧。

尽管可重装药物输送平台在治疗各种疾病方面广受好评，但水凝胶之间的凝胶-凝胶界面阻碍了药物之间的凝胶扩散传播，因此限制了水凝胶作为可重装长效药物的应用。在这里，这项研究报告了通过使用由N制成的自修复水凝胶来绕过此障碍的方法。羧乙基壳聚糖和海藻酸钠二醛，通过可逆的席夫碱键交联。可注射和生物粘附的水凝胶显示47 s的快速胶凝时间。动态自我修复过程可将碳量子点（C-dots）有效扩散扩散到相邻的水凝胶中，因此，C-dots可用于清除遥远炎症部位的活性氧。具体而言，经过三个连续的装填步骤后，C点在自愈水凝胶中的扩散传输量是非自愈对应物中C点的扩散传输量的七倍。在体内，在用可再装自愈水凝胶治疗的组中，注射部位鼠皮的苏木精和曙红染色未显示明显的炎症症状。