Two recent articles advance our understanding of mycobacterial pathogenesis, revealing key roles for bacterially derived phenolic glycolipids (PGLs). In leprosy, Mycobacterium leprae PGL-1 uniquely subverts local macrophages to produce neurotoxic nitric oxide (NO), leading to nerve demyelination. In a related model, Mycobacterium marinum PGL stimulates the recruitment of growth-conducive monocytes to sites of initial infection as an early immune evasion strategy.

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犯罪伙伴：酚类糖脂和巨噬细胞

最近的两篇文章提高了我们对分枝杆菌发病机理的理解，揭示了细菌衍生的酚糖脂（PGL）的关键作用。在麻风病中，麻风分枝杆菌PGL-1独特地破坏了局部巨噬细胞以产生神经毒性一氧化氮（NO），从而导致神经脱髓鞘。在一个相关的模型中，作为一种早期的免疫逃避策略，海事分枝杆菌PGL刺激生长诱导单核细胞募集到初始感染部位。