Metalloporphyrins serve key roles in natural biological processes and also have demonstrated utility for biomedical applications. They can be encapsulated or grafted in conventional nanoparticles or can self-assemble themselves at the nanoscale. A wide range of metals can be stably chelated either before or after porphyrin nanoparticle formation, without the necessity of any additional chelator chemistry. The addition of metals can substantially alter a range of behaviors such as modulating phototherapeutic efficacy; conferring responsiveness to biological stimuli; or providing contrast for magnetic resonance, positron emission or surface enhanced Raman imaging. Chelated metals can also provide a convenient handle for bioconjugation with other molecules via axial coordination. This review provides an overview of some recent biomedical, nanoparticulate approaches involving gain-of-function metalloporphyrins and related molecules.

中文翻译：

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金属卟啉纳米颗粒：协调多种治疗诊断功能。

金属卟啉在自然生物过程中发挥着关键作用，并且也已被证明可用于生物医学应用。它们可以被封装或接枝在传统的纳米颗粒中，或者可以在纳米尺度上自组装。在卟啉纳米颗粒形成之前或之后，可以稳定地螯合多种金属，而无需任何额外的螯合剂化学。添加金属可以显着改变一系列行为，例如调节光疗功效；赋予对生物刺激的反应能力；或为磁共振、正电子发射或表面增强拉曼成像提供对比度。螯合金属还可以通过轴向配位为与其他分子的生物共轭提供方便的处理。本综述概述了一些涉及功能获得性金属卟啉和相关分子的最新生物医学纳米颗粒方法。