A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel’s average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.

中文翻译：

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PVLA-PEG-PVLA 热敏可生物降解水凝胶的设计与表征

一组聚(δ-戊内酯-co - d , l-丙交酯) -b-聚(乙二醇) -b-聚(δ-戊内酯-co - d , l-lactide) (PVLA-PEG-PVLA) 三嵌段共聚物合成并使用流变学、低温-TEM、低温-SEM、SANS 和降解研究表征溶液性质。这种聚合物在室温下在水中自组装成具有花状球形胶束的低粘度流体，并在加热时转变为蠕虫状形态，并伴有凝胶化。在更高的温度下观察到脱水收缩。在生理温度 (37 °C) 下，水凝胶的平均孔径约为 600 nm。PVLA-PEG-PVLA 凝胶在细胞培养基中约 45 天降解，使这种独特的水凝胶成为生物医学应用的有希望的候选者。