We developed an ultrasound–chemical hybrid tool to precisely manipulate cellular activities. A focused ultrasound coupled with gas-filled microbubbles was used to rapidly trigger the influx of membrane-impermeable chemical dimerizers into living cells to regulate protein dimerization and location without inducing noticeable toxicity. With this system, we demonstrated the successful modulation of phospholipid metabolism triggered by a short pulse of ultrasound exposure. Our technique offers a powerful and versatile tool for using ultrasound to spatiotemporally manipulate the cellular physiology in living cells.

中文翻译：

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使用超声-化学混合工具处理细胞活动

我们开发了一种超声化学混合工具，可以精确地操纵细胞活动。聚焦超声结合充气微泡被用来迅速触发膜不渗透性化学二聚体流入活细胞，以调节蛋白质二聚体和位置，而不会引起明显的毒性。有了这个系统，我们证明了超声波短脉冲触发的磷脂代谢的成功调节。我们的技术为使用超声波时空操纵活细胞中的细胞生理提供了强大而通用的工具。