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The spectrum of T cell metabolism in health and disease
Nature Reviews Immunology ( IF 100.3 ) Pub Date :  , DOI: 10.1038/nri.2017.99
Glenn R. Bantug,Lorenzo Galluzzi,Guido Kroemer,Christoph Hess

In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral tissues in search of cognate antigens. During infection, T cells that encounter cognate antigens are activated and — in a context-specific manner — proliferate and/or differentiate to become effector T cells. This process is accompanied by important changes in cellular metabolism (known as metabolic reprogramming). The magnitude and spectrum of metabolic reprogramming as it occurs in T cells in the context of acute infection ensure host survival. By contrast, altered T cell metabolism, and hence function, is also observed in various disease states, in which T cells actively contribute to pathology. In this Review, we introduce the idea that the spectrum of immune cell metabolic states can provide a basis for categorizing human diseases. Specifically, we first summarize the metabolic and interlinked signalling requirements of T cells responding to acute infection. We then discuss how metabolic reprogramming of T cells is linked to disease.

中文翻译:

健康和疾病中T细胞代谢的光谱

在健康个体中,代谢静止的T细胞会检查淋巴结和周围组织,以寻找相关抗原。在感染过程中,遇到关联抗原的T细胞被激活,并以特定环境的方式增殖和/或分化为效应T细胞。这个过程伴随着细胞代谢的重要变化(称为代谢重编程)。在急性感染的情况下,在T细胞中发生的代谢重编程的幅度和频谱可确保宿主存活。相反,在各种疾病状态下也观察到改变的T细胞代谢,进而改变了功能,在这些疾病中,T细胞积极地参与了病理学的研究。在本综述中,我们介绍了免疫细胞代谢状态的光谱可以为分类人类疾病提供基础的想法。具体来说,我们首先总结了对急性感染有反应的T细胞的代谢和相互联系的信号传导要求。然后,我们讨论T细胞的代谢重编程如何与疾病相关。
更新日期:2017-09-25
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