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The epidermal growth factor network: role in oocyte growth, maturation and developmental competence
Human Reproduction Update ( IF 13.3 ) Pub Date : 2017-09-20 , DOI: 10.1093/humupd/dmx029
Dulama Richani 1 , Robert B Gilchrist 1
Affiliation  

The LH surge induces great physiological changes within the preovulatory follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting embryo and foetal development. However, unlike mural granulosa cells, the oocyte and its surrounding cumulus cells are not directly responsive to LH, indicating that the LH signal is mediated by secondary factors produced by the granulosa cells. The mechanisms by which the oocyte senses the ovulatory LH signal and hence prepares for ovulation has been a subject of considerable controversy for the past four decades. Within the last 15 years several significant insights have been made into the molecular mechanisms orchestrating oocyte development, maturation and ovulation. These findings centre on the epidermal growth factor (EGF) pathway and the role it plays in the complex signalling network that finely regulates oocyte maturation and ovulation.

中文翻译:

表皮生长因子网络:在卵母细胞生长,成熟和发育能力中的作用

LH激增会在排卵前卵泡中引起巨大的生理变化,最终导致能够支持胚胎和胎儿发育的成熟卵母细胞排卵。但是,与壁上的颗粒细胞不同,卵母细胞及其周围的卵丘细胞不直接响应LH,这表明LH信号是由颗粒细胞产生的次级因子介导的。在过去的四十年中,卵母细胞感觉到排卵LH信号从而准备排卵的机制一直是一个有争议的话题。在过去的15年中,在协调卵母细胞发育,成熟和排卵的分子机制方面取得了一些重要见解。
更新日期:2017-09-20
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