Several months ago, as we were launching theCell Chemical BiologyCall, we took some time to explain why we believe that chemical biology epitomizes what a multidisciplinary scientific field is all about (http://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30104-6). It is a discipline that successfully operates within the chemistry-biology-medicine continuum, thanks to its multidisciplinary nature and the mindset that its members have. Cancer research is one of those areas where chemical biology efforts have made remarkable and real scientific and clinical contributions. Efforts in chemical biology laboratories have produced a range of small molecules that are making a difference in the clinic today. Probably the most prominent example of such a compound is imatinib, which targets the active sites of a number of tyrosine kinases, including—most importantly—Bcr-abl kinase, and whose success solidified the importance of targeting oncogene addiction in cancer drug discovery anticancer drugs.

中文翻译：

---

化学生物学作为癌症研究和药物发现创新的驱动力

几个月前，当我们发起“细胞化学生物学呼叫”时，我们花了一些时间来解释为什么我们认为化学生物学是多学科科学领域的全部缩影（http://www.cell.com/cell-chemical-biology/全文/ S2451-9456（17）30104-6）。这是一门在化学，生物学，医学连续性领域内成功运作的学科，这要归功于它的多学科性质和成员所拥有的思维方式。癌症研究是化学生物学工作做出了杰出而真正的科学和临床贡献的领域之一。化学生物学实验室的努力已经产生了许多小分子，这些小分子正在当今的临床中有所作为。这类化合物最突出的例子可能是伊马替尼，该药靶向许多酪氨酸激酶的活性位点，