Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have been effective cancer treatments for decades, and the success of these therapies demonstrates that a therapeutic window exists to target malignant metabolism. New insights into the differential metabolic dependencies of tumors have provided novel therapeutic strategies to exploit altered metabolism, some of which are being evaluated in preclinical models or clinical trials. Here, we review our current understanding of cancer metabolism and discuss how this might guide treatments targeting the metabolic requirements of tumor cells.

中文翻译：

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癌症治疗的靶向代谢

代谢重编程有助于肿瘤的发展，并引入可用于治疗癌症的代谢负担。几十年来，针对代谢的化疗一直是有效的癌症治疗方法，这些疗法的成功表明存在针对恶性代谢的治疗窗口。对肿瘤不同代谢依赖性的新见解提供了利用改变的代谢的新治疗策略，其中一些正在临床前模型或临床试验中进行评估。在这里，我们回顾了目前对癌症代谢的理解，并讨论了如何指导针对肿瘤细胞代谢需求的治疗。