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Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
Nature Reviews Neuroscience ( IF 34.7 ) Pub Date : 2017-09-21 , DOI: 10.1038/nrn.2017.110
Urte Neniskyte , Cornelius T. Gross

The final stage of brain development is associated with the generation and maturation of neuronal synapses. However, the same period is also associated with a peak in synapse elimination — a process known as synaptic pruning — that has been proposed to be crucial for the maturation of remaining synaptic connections. Recent studies have pointed to a key role for glial cells in synaptic pruning in various parts of the nervous system and have identified a set of critical signalling pathways between glia and neurons. At the same time, brain imaging and post-mortem anatomical studies suggest that insufficient or excessive synaptic pruning may underlie several neurodevelopmental disorders, including autism, schizophrenia and epilepsy. Here, we review current data on the cellular, physiological and molecular mechanisms of glial-cell-dependent synaptic pruning and outline their potential contribution to neurodevelopmental disorders.



中文翻译:

错误的园丁:依赖神经胶质细胞的突触修剪和神经发育障碍

脑发育的最后阶段与神经元突触的产生和成熟有关。然而,同一时期也与突触消除的峰值相关联(称为突触修剪的过程),该峰值被认为对于剩余突触连接的成熟至关重要。最近的研究指出神经胶质细胞在神经系统各个部位的突触修剪中起关键作用,并确定了神经胶质和神经元之间的一组关键信号通路。同时,大脑成像和验尸研究表明,不足或过度的突触修剪可能是多种神经发育障碍的原因,包括自闭症,精神分裂症和癫痫病。在这里,我们回顾了有关移动电话的当前数据,

更新日期:2017-09-21
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