The application of on‐line mass spectrometry for direct analysis of chemical and other types of process continues to grow in importance and impact. The ability of the technique to characterize many aspects of a chemical reaction such as product and impurity formation, along with reactant consumption in a single experiment is key to its adoption and development. Innovations in ionization techniques and mass spectrometry instrumentation are enabling this adoption. An increasing range of ambient ionization techniques make on‐line mass spectrometry applicable to a large range of chemistries. The academic development and commercialization of small footprint portable/transportable mass spectrometers is providing technology that can be positioned with any process under investigation. These developments, coupled with research into new ways of sampling representatively from both the condensed and gaseous phases, are positioning mass spectrometry as an essential technology for on‐line process optimization, understanding and intelligent control. It is recognized that quantitative capability of mass spectrometry in this application can cause some resistance to its adoption, but research activities to tackle this limitation are on‐going.

中文翻译：

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质谱在线监测反应，化学反应分析的现代方法

在线质谱法在化学和其他类型过程的直接分析中的应用不断增长，其重要性和影响也在不断增长。该技术能够表征化学反应的许多方面（例如产物和杂质形成）以及在单个实验中消耗反应物的能力是其采用和开发的关键。电离技术和质谱仪器的创新使这种应用成为可能。越来越多的环境电离技术使在线质谱分析法适用于各种化学领域。小型便携式/便携式质谱仪的学术发展和商业化提供了可以在所研究的任何过程中定位的技术。这些发展，结合对代表性的从冷凝相和气相中采样的新方法的研究，质谱已被定位为在线过程优化，理解和智能控制的必不可少的技术。公认的是，质谱在此应用中的定量功能可能会对它的采用产生一定的抵制，但是针对这一局限性的研究活动正在进行中。