Intravenous immunoglobulin (IVIG), a pooled normal IgG formulation prepared from thousands of healthy donors’ plasma, is extensively used for the immunotherapy of autoimmune and inflammatory disorders. Recent reports demonstrate that IVIG exerts anti-inflammatory actions by stimulating the activation and expansion of regulatory T (Treg) cells by multiple mechanisms via antigen-presenting cells (APCs).

中文翻译：

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循环正常IgG作为调节性T细胞的刺激物：静脉免疫球蛋白的经验教训

静脉免疫球蛋白（IVIG）是一种由数千名健康供体血浆制备的正常IgG汇集制剂，已广泛用于自身免疫和炎症性疾病的免疫治疗。最近的报道表明，IVIG通过多种机制通过抗原呈递细胞（APC）刺激调节性T（Treg）细胞的激活和扩展而发挥抗炎作用。