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Programmed Cell Death and Inflammation: Winter Is Coming
Trends in Immunology ( IF 16.8 ) Pub Date : 2017-07-19 00:00:00 , DOI: 10.1016/j.it.2017.06.009
Joseph P. Kolb,Thomas H. Oguin,Andrew Oberst,Jennifer Martinez

The life of an organism requires the assistance of an unlikely process: programmed cell death. Both development and the maintenance of homeostasis result in the production of superfluous cells that must eventually be disposed of. Furthermore, programmed cell death can also represent a defense mechanism; for example, by depriving pathogens of a replication niche. The responsibility of handling these dead cells falls on phagocytes of the immune system, which surveil their surroundings for dying or dead cells and efficiently clear them in a quiescent manner. This process, termed efferocytosis, depends on cooperation between the phagocyte and the dying cell. In this review we explore different types of programmed cell death and their impact on innate immune responses.

中文翻译:

程序性细胞死亡和炎症:冬天来了

生物的生命需要一个不可能的过程的协助:程序性细胞死亡。稳态的发展和维持都导致产生多余的细胞,这些细胞最终必须被丢弃。此外,程序性细胞死亡也可以代表一种防御机制。例如,通过剥夺病原体的复制位。处理这些死细胞的责任落在免疫系统的吞噬细胞上,吞噬细胞会监视周围环境中是否有垂死或死细胞,并以静态方式有效清除它们。这个过程称为胞吞作用,取决于吞噬细胞和垂死细胞之间的协同作用。在这篇综述中,我们探讨了不同类型的程序性细胞死亡及其对先天免疫反应的影响。
更新日期:2017-09-20
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