Neurons are akin to modern cities in that both are dependent on robust transport mechanisms. Like the best mass transit systems, trafficking in neurons must be tailored to respond to local requirements. Neurons depend on both high-speed, long-distance transport and localized dynamics to correctly deliver cargoes and to tune synaptic responses. Here, we focus on the mechanisms that provide localized regulation of the transport machinery, including the cytoskeleton and molecular motors, to yield compartment-specific trafficking in the axon initial segment, axon terminal, dendrites and spines. The synthesis of these mechanisms provides a sophisticated and responsive transit system for the cell.

中文翻译：

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细胞骨架组织对神经元转运的局部调节的影响

神经元类似于现代城市，两者都依赖强大的运输机制。像最佳的大众运输系统一样，必须调整神经元的运输以适应当地的需求。神经元既依赖于高速，长途运输，又依赖于局部动力学，以正确地运送货物并调节突触反应。在这里，我们专注于提供局部调节运输机制的机制，包括细胞骨架和分子马达，以在轴突起始段，轴突末端，树突和棘突中产生特定于隔室的运输。这些机制的综合为细胞提供了复杂且响应迅速的转运系统。